This new FDA-approved treatment for migraines includes a computer chip and delivers a prescription drug through a patch that can be wrapped around a patient's upper arm or thigh. (Product photo courtesy of NuPathe)
How the Patch Works
Named Zecuity, the battery-powered patch is manufactured by the pharmaceutical company NuPathe. About 8 inches long and 4 inches wide, it wraps around the arm or thigh much like an ace bandage. According to Bastings, it uses an electrical current to move the drug through the skin over the course of four hours. A small battery and computer chip regulate the charge to make sure the patient gets the right dosage.
The patch provides an alternative to pills, nasal sprays and injections. "Many migraine sufferers experience debilitating pain — sometimes so acute that they can't swallow a pill," says Bastings.
He adds that some people don't like the unpleasant taste the nasal spray can leave behind, and others are uncomfortable with injecting themselves.
That said, the patch does have some drawbacks, notes Bastings. For one thing, it's large enough that it can show when worn under short-sleeved shirts or shorts, and requires some privacy (and at times, the need to undress) to put it on. "For many people, popping a pill is a lot more immediate and simple," Bastings says.
About 25 percent of participants in the clinical study complained of a painful sensation at the patch application site. Others didn't like the reddening that most patients developed at the application site after using the patch.
What Causes a Migraine?
According to the National Institutes of Health (NIH), about 12 percent of the U.S. population experience migraines. Migraines affect both children and adults, but affect adult women three times more often than men.
Bastings explains that migraines are neurovascular headaches. They are characterized by throbbing and pulsating pain caused by the a temporary widening of blood vessels in the brain, triggered by abnormal activation of nerve pathways involved in the transmission of pain signals.
Characteristics of a migraine frequently include:
- Pain typically on one side of the head
- Pain that has a pulsating or throbbing quality
- Moderate to intense pain that affects daily activities
- Nausea or vomiting
- Sensitivity to light or sound
- Aura, visual disturbances that signal the beginning, such as dots, flashing lights or blind spots
Bastings also says that a number of studies show that migraines are underdiagnosed by patient and physician, alike. "Many people don't recognize the symptoms as belonging to migraine," he says. Or they don't think of sharing information about the occasional headache with their physician, even if it is severe.
(注: 以下幾張圖片是閩姑加的.不在FDA鏈接的原文裏)
圖1 Zecuity Patch 藥物釋放示意圖
圖2 Pathways of Migraine
圖4 不同種類的頭痛
FDA-Approved Drugs
FDA has approved a number of drugs for treating acute migraine, including the triptans (such as Imitrex), which bind to serotonin receptors in the brain nerve fibers and blood vessels. (Serotonin acts as a neurotransmitter, a type of chemical that helps relay signals from one area of the brain to another.) There are also non-prescription drugs available "over the counter," such as ibuprofen, aspirin and acetaminophen.
"These abortive medications work most effectively if taken early in the attack," Bastings notes.
Many people who experience frequent or severe migraines may use preventive medications, including beta-blockers, a type of blood pressure drug, such as metoprolol. Certain antiepileptic drugs are also prescribed, such as topiramate and divalproex sodium.
In October 2010, FDA also approved Botulinum toxin (known as Botox) for use in treating patients who suffer chronic migraines at least 15 days a month.
Another way to prevent migraines is to learn your personal "triggers" for the headache, Bastings says. Common ones include:
- Hormonal changes in women, with migraines frequently occurring around the menstrual cycle;
- Certain foods and beverages, such as alcoholic and caffeinated drinks, chocolate and aged cheeses;
- Stress; and
- Changes in waking and sleeping patterns.
"It certainly can help to know your triggers and avoid them when possible," Bastings says. "Of course if a major trigger is stress, few of us can entirely avoid that in our lives."
This article appears on FDA's Consumer Updates page, which features the latest on all FDA-regulated products.
March 21, 2013
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