老年癡呆症最新進展
From NPR News
1. 老年癡呆症不光有記憶問題，還可以致命
2. 在美國，在過去的十年，老年癡呆症增加了68%
3. 美國現有超過五百萬老年癡呆症患者，預計到2050年，會增長到一點四億
4. 到現在還沒有有效的治療方法，這些患者的十年死亡率非常大
5. 如果一個70多歲的人有這個病的話，死亡率會比無此病的同令人多一倍。
6. 在此病的早中期，神經細胞的變化主要影響記憶和行為，到了晚期，大腦的變化最終會影響到身體的基本功能，包括吞咽。
7. 老年癡呆症和其他癡呆症可以影響到個人的平衡功能和行走的能力，所以可導致跌到和因此帶來的損傷
8. 晚期老年癡呆症的常見死亡原因是發熱和感染
9. 醫療人員向患者及家屬闡明老年癡呆症不但影響記憶也影響軀體是重要的
10. 知道癡呆是絕症，我們可以更好的向家屬提供谘詢使他們有準備
Summary by 回家路 :
- Alzheimer's disease doesn't just steal memories. It takes lives
- The disease increased by 68 percent between 2000 and 2010
- More than 5 million people in the U.S. have the disease, and that number could reach nearly 14 million by 2050.
- There are still no effective treatments for Alzheimer's, and people who have the disease face a greatly increased risk of dying within 10 years
- If a person is living with Alzheimer's disease in their 70s, it actually doubles their mortality risk
- In the early and middle stages, the changes to those nerve cells mostly affect memory and behavior problems, But as the disease progresses toward the end stage, the brain changes eventually affect basic bodily functions, including swallowing
- Alzheimer's and other dementias also can affect a person's balance and ability to walk, which can lead to falls and injury
- The most common causes of death in people with late-stage Alzheimer's are fevers and infections.
- The disease goes after the body as well as the mind. So it's important that health care professionals explain this aspect of the disease
- By understanding dementia as a terminal illness, we can much better prepare and counsel families about what to expect at the end stage
Original artical:
Alzheimer's 'Epidemic' Now A Deadlier Threat To Elderly
NPR News by Jon Hamilton
March 19, 2013 3:15 AM
Alzheimer's disease doesn't just steal memories. It takes lives.
The disease is now the sixth leading cause of death in the U.S., and figures released Tuesday by the Alzheimer's Association show that deaths from the disease increased by 68 percent between 2000 and 2010.
"It's an epidemic, it's on the rise, and currently [there is] no way to delay it, prevent it or cure it," says Maria Carrillo, a neuroscientist with the Alzheimer's Association. More than 5 million people in the U.S. have the disease, she says, and that number could reach nearly 14 million by 2050.
One reason Alzheimer's deaths are going up is that deaths from other causes, like heart disease and prostate cancer, are going down, Carrillo says. "We're living longer," she says, "and unfortunately age is still the greatest risk factor for Alzheimer's disease."
There are still no effective treatments for Alzheimer's, and people who have the disease face a greatly increased risk of dying within 10 years, according to an analysis by the Alzheimer's Association of data from the Centers for Disease Control and Prevention.
"If a person is living with Alzheimer's disease in their 70s, it actually doubles their mortality risk," Carrillo says.
It's still tricky to decide when to blame Alzheimer's for the death of a particular person, though, says Susan Mitchell, a professor of medicine at Harvard and a scientist at Hebrew Senior Life Institute for Aging Research. That's because Alzheimer's patients tend to have other health problems as well, she says.
As a result, Mitchell says, many death certificates still list pneumonia or some other disease as the cause of death, even when the underlying problem is Alzheimer's. "So even the statistics that show dementia increasing as a cause of death are a gross underestimate," she says.
Because Alzheimer's damages cells in the brain, it often kills in ways that are indirect, says Mitchell, an author of a 2009 study of more than 300 nursing home residents with advanced dementia. "In the early and middle stages, the changes to those nerve cells mostly affect memory and behavior problems," she says. "But as the disease progresses toward the end stage, the brain changes eventually affect basic bodily functions," including swallowing.
This seemingly simple act requires the brain to orchestrate a complex sequence of muscular contractions, and that sequence often goes awry in people in the later stages of Alzheimer's, Mitchell says. "That can often lead to a lung infection if the food goes down the wrong way, and that is a common cause of pneumonia," she says.
Alzheimer's and other dementias also can affect a person's balance and ability to walk, which can lead to falls and injury, Mitchell says. And she says damage to the brain itself can cause fatal seizures.
But the most common causes of death in people with late-stage Alzheimer's are fevers and infections, Mitchell says. She says this is because the disease has gradually eroded the body's defenses.
"The body is so debilitated, frail and weak at the end of dementia that some of the usual immunological and metabolic factors that can protect a healthy body from infections and fevers really become susceptible," Mitchell says.
Yet many families of people with Alzheimer's don't realize that the disease goes after the body as well as the mind, Mitchell says. So it's important that health care professionals explain this aspect of the disease, she says.
"By understanding dementia as a terminal illness, we can much better prepare and counsel families about what to expect at the end stage," Mitchell says. And research shows that when they fully understand what is happening, she says, they are less likely to request extreme measures to keep a family member alive
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