https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087011/#!po=49.1379
我總結一下文章的意思：
1）用藥十天也是安全的。2）但模型顯示五天十天效果一樣. 3）用藥五天後，大概相當於感染九天後，病毒動力學主要由清除過程來決定，而藥物阻斷的病毒複製相對來說不重要了。所以藥廠用五天作為療程。
（我不了解新冠病毒在體內複製清除過程，隻是照搬文章內容。）
In fact, QSP modeling predicted that 5 days of dosing of oral nirmatrelvir/ritonavir 300/100 mg b.i.d. would demonstrate meaningful antiviral effect, supporting this duration for phase II/III trials. Dosing for > 5 days in symptomatic patients was predicted to have no additional benefit. The physiological rationale for this observation is that after 5 days of dosing (~ 9 days after symptom onset and about 2 weeks after infection 25 , 36 , 37 ) viral dynamics may be almost entirely driven by viral clearance rates, and not by viral replication.
