https://www.nature.com/articles/s41598-022-20202-x
Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp.
喜歡這篇文章，從方法到語氣。
生物圈，很多文章充滿著虛妄的傲慢。好像新冠已經是他們的囊中物了，
這文章上來首先就是承認，C19重症在科學上依然是個迷。然後證明萊姆病抗體與c19重症的強關聯，然後承認裏因果性原理的理解還早。
語氣上顯示了傳統科學家的嚴謹。
Predictors for the risk of severe COVID-19 are crucial for patient care and control of the disease. Other infectious diseases as potential comorbidities in SARS-CoV-2 infection are still poorly understood. Here we identify association between the course of COVID-19 and Lyme disease (borreliosis), caused by Borrelia burgdorferi transmitted to humans by ticks. Exposure to Borrelia was identified by multi-antigenic (19 antigens) serological testing of patients: severe COVID-19 (hospitalized), asymptomatic to mild COVID-19 (home treated or not aware of being infected), and not infected with SARS-CoV-2. Increased levels of Borrelia-specific IgGs strongly correlated with COVID-19 severity and risk of hospitalization. This suggests that a history of tick bites and related infections may contribute to the risks in COVID-19. Though mechanisms of this link is not clear yet, screening for antibodies targeting Borrelia may help accurately assess the odds of hospitalization for SARS-CoV-2 infected patients, supporting efforts for efficient control of COVID-19.
嚴重 COVID-19 風險的預測因子對於患者護理和疾病控製至關重要。其他傳染病作為 SARS-CoV-2 感染的潛在合並症仍然知之甚少。在這裏，我們確定了 COVID-19 病程與萊姆病（疏螺旋體病）之間的關聯，萊姆病是由伯氏疏螺旋體通過蜱傳播給人類引起的。通過對患者的多抗原（19 種抗原）血清學檢測確定是否接觸過疏螺旋體：重症 COVID-19（住院）、無症狀至輕度 COVID-19（家庭治療或不知道被感染）和未感染 SARS-CoV -2。疏螺旋體特異性 IgG 水平升高與 COVID-19 的嚴重程度和住院風險密切相關。這表明蜱叮咬和相關感染的病史可能會增加 COVID-19 的風險。盡管這種聯係的機製尚不清楚，但篩查針對疏螺旋體的抗體可能有助於準確評估 SARS-CoV-2 感染患者的住院幾率，從而支持有效控製 COVID-19 的努力。
