https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012513/
Abstract
The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
16. Conclusions
There has been an unwavering message about the safety and efficacy of mRNA vaccinations against SARS-CoV-2 from the public health apparatus in the US and around the globe. The efficacy is increasingly in doubt, as shown in a recent letter to the Lancet Regional Health by Günter Kampf (2021b). Kampf provided data showing that the vaccinated are now as likely as the unvaccinated to spread disease. He concluded: “It appears to be grossly negligent to ignore the vaccinated population as a possible and relevant source of transmission when deciding about public health control measures.” Moreover, the inadequacy of phase I, II, and III trials to evaluate mid-term and long-term side effects from mRNA genetic vaccines may have been misleading on their suppressive impact on the innate immunity of the vaccinees.
In this paper, we call attention to three very important aspects of the safety profile of these vaccinations. First is the extensively documented subversion of innate immunity, primarily via suppression of IFN-α and its associated signaling cascade. This suppression will have a wide range of consequences, not the least of which include the reactivation of latent viral infections and the reduced ability to effectively combat future infections. Second is the dysregulation of the system for both preventing and detecting genetically driven malignant transformation within cells and the consequent potential for vaccination to promote those transformations. Third, mRNA vaccination potentially disrupts intracellular communication carried out by exosomes, and induces cells taking up spike glycoprotein mRNA to produce high levels of spike-glycoprotein-carrying exosomes, with potentially serious inflammatory consequences. Should any of these potentials be fully realized, the impact on billions of people around the world could be enormous and could contribute to both the short-term and long-term disease burden our health care system faces.
Given the current rapidly expanding awareness of the multiple roles of G4s in regulation of mRNA translation and clearance through stress granules, the increase in pG4s due to enrichment of GC content as a consequence of codon optimization has unknown but likely far-reaching consequences. Specific analytical evaluation of the safety of these constructs in vaccines is urgently needed, including mass spectrometry for identification of cryptic expression and immunoprecipitation studies to evaluate the potential for disturbance of or interference with the essential activities of RNA and DNA binding proteins.
It is essential that further studies be conducted to determine the extent of the potential pathological consequences outlined in this paper. It is not practical for these vaccinations to be considered part of a public health campaign without a detailed analysis of the human impact of the potential collateral damage. VAERS and other monitoring systems should be optimized to detect signals related to the health consequences of mRNA vaccination we have outlined. We believe the upgraded VAERS monitoring system described in the Harvard Pilgrim Health Care, Inc. study, but unfortunately not supported by the CDC, would be a valuable start in this regard (Lazarus et al., 2010).
In the end, billions of lives are potentially at risk, given the large number of individuals injected with the SARS-CoV-2 mRNA vaccines and the broad range of adverse outcomes we have described. We call on the public health institutions to demonstrate, with evidence, why the issues discussed in this paper are not relevant to public health, or to acknowledge that they are and to act accordingly. Furthermore, we encourage all individuals to make their own health care decisions with this information as a contributing factor in those decisions.
穀歌翻譯
抽象的
為了應對 Covid-19 的公共衛生危機，mRNA SARS-CoV-2 疫苗上市。在傳染病的背景下使用 mRNA 疫苗沒有先例。疫苗 mRNA 的許多改變隱藏了 mRNA 免受細胞防禦的影響，並促進了更長的生物半衰期和刺突蛋白的高產量。然而，對疫苗的免疫反應與對 SARS-CoV-2 感染的免疫反應非常不同。在本文中，我們提供的證據表明，疫苗接種會嚴重損害 I 型幹擾素信號，從而對人類健康產生多種不利影響。吸收了疫苗納米顆粒的免疫細胞將大量含有刺突蛋白的外泌體以及關鍵的 microRNA 釋放到循環中，這些 microRNA 在遠處的受體細胞中誘導信號傳導反應。我們還確定了蛋白質合成和癌症監測的監管控製中潛在的嚴重幹擾。這些幹擾可能與神經退行性疾病、心肌炎、免疫性血小板減少症、貝爾氏麻痹、肝病、適應性免疫受損、DNA損傷反應受損和腫瘤發生有因果關係。我們展示了來自 VAERS 數據庫的證據來支持我們的假設。我們相信，對 mRNA 疫苗的全麵風險/收益評估會質疑它們對公共衛生的積極貢獻。
圖 1
16. 結論
美國和全球的公共衛生機構一直在堅定不移地發出關於 SARS-CoV-2 mRNA 疫苗的安全性和有效性的信息。正如 Günter Kampf (2021b) 最近給《柳葉刀地區健康》的一封信中所顯示的那樣，療效越來越受到質疑。 Kampf 提供的數據顯示，接種疫苗的人現在與未接種疫苗的人一樣可能傳播疾病。他總結道：“在決定公共衛生控製措施時，忽視接種疫苗的人群可能是相關的傳播源，這似乎是嚴重疏忽。”此外，I、II 和 III 期試驗不足以評估 mRNA 基因疫苗的中期和長期副作用，這可能會誤導它們對疫苗接種者先天免疫的抑製作用。
在本文中，我們提請注意這些疫苗接種安全性的三個非常重要的方麵。首先是廣泛記錄的先天免疫顛覆，主要是通過抑製 IFN-α 及其相關的信號級聯。這種抑製將產生廣泛的後果，其中最重要的是包括潛伏病毒感染的重新激活和有效對抗未來感染的能力降低。其次是用於預防和檢測細胞內基因驅動的惡性轉化的係統失調，以及由此產生的疫苗接種促進這些轉化的潛力。第三，mRNA 疫苗接種可能會破壞外泌體進行的細胞內通訊，並誘導細胞攝取刺突糖蛋白 mRNA 以產生高水平的攜帶刺突糖蛋白的外泌體，從而可能產生嚴重的炎症後果。如果充分發揮這些潛力中的任何一個，對全球數十億人的影響可能是巨大的，並可能加劇我們的醫療保健係統麵臨的短期和長期疾病負擔。
鑒於目前對 G4s 在通過應激顆粒調節 mRNA 翻譯和清除中的多種作用的認識迅速擴大，由於密碼子優化導致 GC 含量富集導致 pG4s 的增加具有未知但可能影響深遠的後果。迫切需要對疫苗中這些構建體的安全性進行具體的分析評估，包括用於鑒定隱蔽表達的質譜和免疫沉澱研究，以評估幹擾或幹擾 RNA 和 DNA 結合蛋白的基本活性的可能性。
必須進行進一步的研究以確定本文概述的潛在病理後果的程度。如果不詳細分析潛在附帶損害對人類的影響，將這些疫苗接種視為公共衛生運動的一部分是不切實際的。應優化 VAERS 和其他監測係統，以檢測與我們概述的 mRNA 疫苗接種的健康後果相關的信號。我們相信，哈佛 Pilgrim Health Care, Inc. 研究中描述的升級後的 VAERS 監測係統，但不幸的是沒有得到 CDC 的支持，將是這方麵的一個有價值的開端（Lazarus 等，2010）。
最終，鑒於大量個體注射了 SARS-CoV-2 mRNA 疫苗以及我們描述的廣泛的不良後果，數十億人的生命可能處於危險之中。我們呼籲公共衛生機構用證據證明為什麽本文討論的問題不相關
