自然雜誌：先滅活再R苗的“雜打”效果好

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

https://www.nature.com/articles/s41467-022-30340-5

Abstract

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies.

Here we observed that an mRNA vaccine booster in individuals vaccinated with two doses of inactivated vaccine significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1 + S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine.

The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA-vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine.

This heterologous vaccination regime furthermore significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response, compared to two or three doses of homologous inactivated vaccine.

Our study demonstrates that mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant.

 

所有跟帖： 

• 也許雜打能幫中國 -fuz- ♂ (0 bytes) () 05/15/2022 postreply 04:32:32

• 朝鮮製作的認識奧密克戎BA.2變異株公益宣傳片和疫情數據（ZT） -5181- ♂ (588003 bytes) () 05/15/2022 postreply 07:06:43

• 看來不打疫苗、沒有特效藥也能抗過去啊 -fuz- ♂ (0 bytes) () 05/15/2022 postreply 08:32:25

• 我覺得很靠譜啊 -天兒晴了- ♀ (0 bytes) () 05/15/2022 postreply 08:34:03

• 這什麽醫生？呼吸道病毒感染很容易夾雜細菌感染,用抗生素有啥奇怪的？ -周老大- ♂ (0 bytes) () 05/15/2022 postreply 09:44:39

• 美國醫生對抗菌素相當慎重 -fuz- ♂ (0 bytes) () 05/15/2022 postreply 11:25:50

• 我一個朋友，打過兩次國產疫苗，後來又打了一劑輝瑞也中招了。 -jelous- ♀ (0 bytes) () 05/15/2022 postreply 15:56:00