try her best to do work. try hard. If the work load is too much, just leave it unfinished, and most importantly, DON'T FEEL SORRY ABOUT IT.
don't resign. try to get alone with new boss. have a delightful attitude. don't argue. explain a little but don't get into conflict.
nobody can make your wife unhappy except herself (this is too extreme, i know. but might be useful in this difficult situation). let the drama playing its course. if she is mean, she might get terminated before your wife. who knows.
留得青山在,不怕沒柴燒
誰笑到最後,誰笑得最好