為何不服用keppra?keppra 抑製鈣離子進入神經細胞,抑製興奮。Mg 拮抗,作用類似。

來源: 欲千北 2020-03-23 17:59:17 [] [博客] [舊帖] [給我悄悄話] 本文已被閱讀: 次 (4791 bytes)
本文內容已被 [ 欲千北 ] 在 2020-03-23 18:00:53 編輯過。如有問題,請報告版主或論壇管理刪除.

Mechanism of action[edit]

The exact mechanism by which levetiracetam acts to treat epilepsy is unknown. Levetiracetam does not exhibit pharmacologic actions similar to that of classical anticonvulsants. It does not inhibit voltage-dependent Na+ channels, does not affect GABAergic transmission, and does not bind to GABAergic or glutamatergic receptors.[30] However, the drug binds to SV2A,[31] a synaptic vesicle glycoprotein, and inhibits presynaptic calcium channels,[32] reducing neurotransmitter release and acting as a neuromodulator. This is believed to impede impulse conduction across synapses.[33]

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