Breast cancer breakthrough as Cambridge University finds gene behind killer disease
Cambridge University and the Wellcome Trust’s Sanger Institute have discovered the gene responsible for triple negative breast cancer
三陰性乳腺癌(TNBC,約占乳癌患者的15%)是指雌激素受體(ER)、孕激素受體(PR)和人表皮生長因子受體(HER2)均陰性的一種特殊類型的乳腺癌。如果是雌激素受體(ER)、孕酮受體(PR)和HER2陽性,都有辦法治療,且預後一般都不太差。而俗稱“三陰姐”(TNBC)的乳癌患者的預後很差。但是,發表在昨日的Nature Communications上的一篇文章提到: 劍橋大學和威康信托基金會桑格研究所發現了與三陰性乳腺癌有關的基因BCL11A。這意味著可以開發特異性瞄準BCL11A的藥物。終於有了點曙光了。
![](http://i.telegraph.co.uk/multimedia/archive/02752/mammogram_2752356b.jpg)
The gene BCL11A is likely to be behind triple negative breast cancer Photo: ALAMY015 19:39:48
論文截圖:
![](/upload/album/76/df/cc/e8c183932379Ifno6N0N.jpg)
幾張圖幫助你了解TNBC:
TNBC缺乏這三種受體: 雌激素受體(ER)、孕激素受體(PR)和人表皮生長因子受體(HER2):
![](/upload/album/35/c4/c7/c45938032444O3zZef4l.jpg)
有那三種受體時的情況:
![](/upload/album/35/c4/c7/c45938032481vdHWTkLb.jpg)
什麽是乳腺癌?
![](http://triplesteptowardthecure.org/images/slide1.jpg)
什麽是受體? 什麽是荷爾蒙?
![](http://triplesteptowardthecure.org/images/slide2.jpg)
化療的機理:
![](http://triplesteptowardthecure.org/images/slide5.jpg)
![](http://triplesteptowardthecure.org/images/slide6.jpg)
以上圖片來自: http://triplesteptowardthecure.org/understanding.php
論文鏈接:
http://www.nature.com/ncomms/2015/150109/ncomms6987/pdf/ncomms6987.pdf
新聞報道:
http://www.telegraph.co.uk/news/science/science-news/11336050/Breast-cancer-breakthrough-as-Cambridge-University-finds-gene-behind-killer-disease.html
三陰性乳癌的一般知識:
http://throughmylynnz.com/wp-content/uploads/2014/06/TNBC-Infographic.jpg
![](/upload/album/35/c4/c7/c45938032835SZW9pTY5.jpg)