Inflamed epithelium provides adhesion molecules to trap and hold macrophages
Macrophages through scavenger process take up oxidized LDL and become foam cells
Interleukins and growth factors promote proliferation of smooth muscle cells (artery thickening)
Extracellular matrix proteins are degraded
Vulnerable plaque eruption : thrombosis
It does not ignore the role oxidized LDL-p plays in the process.
This theory treats the inflammation of the epithelium as the very first step.
However, there is another theory which depicts the oxidation of LDL-p as the initial and a key step. And what causes the oxidation of LDL-p? LDL receptor's clearance of LDL-p plays a role as well.
So she has an interesting theory but it is not the whole picture.
This is how she described the process
所有跟帖:
• Her whole picture, -益生菌- ♂ (1303 bytes) () 12/01/2014 postreply 21:16:33
• 讀了好幾遍,有不少疑點。待消化一些後再問問題。可能問題會很多!謝謝 -Lily168- ♀ (0 bytes) () 12/01/2014 postreply 22:18:34