維生素D與HDL低和LDL高相關。很可能背後的原因是相同的：在太陽底下跑得少了？

來源: 吃與活 於 2018-11-28 09:52:43 [] [博客] [舊帖] [給我悄悄話] 本文已被閱讀： 次 (34401 bytes)
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https://www.lipidjournal.com/article/S1933-2874(15)00384-0/fulltext

The pathophysiology for deficient 25(OH)D causing an atherogenic lipid profile is unclear. Inadequate dietary intake of vitamin D may reduce calcium absorption in the gastrointestinal system. Prior studies have shown that deficient dietary intake of calcium is associated with higher body weight and a more atherogenic lipid metabolism,53, 54 potentially due to increased lipid metabolism in the body or reduced intake of cholesterol in the gut. However, the observed association between 25(OH)D and dyslipidemia may be confounded by shared metabolic risk factors rather than a causal mechanism. Serum 25(OH)D has been shown to be decreased in obese patients, in whom sequestration of 25(OH)D in body fat reduces detectable 25(OH)D in the serum.55 This phenomenon results in an inverse association between BMI and 25(OH)D. Given that BMI is also associated with dyslipidemia, the presence of obesity may explain the observed association of 25(OH)D with dyslipidemia. Unfortunately, we did not have BMI available in our data set to adjust for this potentially confounding variable. There also appears to be an association between lipid-lowering medication usage and increases in 25(OH)D,56, 57 suggesting that the observed association between low 25(OH)D levels and dyslipidemia may be due to patients with lipid derangements not being on statin therapy.

Although vitamin D supplementation is inexpensive, widely available, and effective in raising serum 25(OH)D, clinical trials have yet to find any link between vitamin D supplementation and changes in lipid profile or reduced CVD mortality.15, 18, 58, 59, 60, 61 Mendelian randomization studies have used single nucleotide polymorphisms leading to variations in 25(OH)D to examine vitamin D's role in the development of an atherogenic lipid profile and CVD.49, 62, 63 These studies have shown evidence that single nucleotide polymorphisms causing a genetically increased RLP-C49 and BMI62 are associated with reduced 25(OH)D. This supports the notion that 25(OH)D may be a marker for overall health rather than an independent risk factor for CVD. As there is not currently any definitive evidence that vitamin D has a causal role in atherosclerotic CVD,21 the associations seen in observational studies may be due to confounding factors that impact both serum 25(OH)D and serum lipids

所有跟帖： 

• 謝謝健康大師 -ylsm- ♀ 給 ylsm 發送悄悄話 (137 bytes) () 11/28/2018 postreply 10:08:48

• 大師 -吃與活- ♂ 給 吃與活 發送悄悄話 吃與活 的博客首頁 (149 bytes) () 11/28/2018 postreply 12:32:44

• 把自己仰視學習的，有巨大幫助的人發自內心稱大師，真心感謝你們的無私分享奉獻 -ylsm- ♀ 給 ylsm 發送悄悄話 (0 bytes) () 11/28/2018 postreply 12:49:16

• 我住在‘陽光州’，每天走路都在太陽底下呢～～～不過看到‘維生素D與HDL低和LDL高相關’，也許還是補點維D吧？ -山菊花- ♀ 給 山菊花 發送悄悄話 山菊花 的博客首頁 (0 bytes) () 11/28/2018 postreply 10:59:11

• 有可能維生素D低是原因，也許也是個結果。 -吃與活- ♂ 給 吃與活 發送悄悄話 吃與活 的博客首頁 (0 bytes) () 11/28/2018 postreply 12:59:24

• 嗯，我準備先去買點維生素D來吃 -山菊花- ♀ 給 山菊花 發送悄悄話 山菊花 的博客首頁 (0 bytes) () 11/28/2018 postreply 14:02:41

• 我曾經有過與你相反的疑問， -阿明.- ♀ 給 阿明. 發送悄悄話 (218 bytes) () 11/28/2018 postreply 14:06:33

• 個人情況還真是千差萬別啊～～～所以我不想隨便吃藥 -山菊花- ♀ 給 山菊花 發送悄悄話 山菊花 的博客首頁 (0 bytes) () 11/28/2018 postreply 14:09:32

• 這僅僅是我唯一提出的“副作用”，其他副作用尚未發現，我已經 -阿明.- ♀ 給 阿明. 發送悄悄話 (50 bytes) () 11/28/2018 postreply 14:31:30

• 你還在吃藏紅花沒有? -甜酒甜- ♀ 給 甜酒甜 發送悄悄話 甜酒甜 的博客首頁 (201 bytes) () 11/28/2018 postreply 11:05:38

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