SAM-e/S-腺苷甲硫氨酸

Background S-腺苷甲硫氨酸

SAMe is made in the body from a reaction between methionine, which is an essential amino acid, and adenosine triphosphate, a molecule that carries energy. SAMe is involved in many different reactions in the body.

SAMe has been used to treat psychiatric illnesses, infertility, liver problems, premenstrual disorders, and musculoskeletal conditions.

SAMe has been widely studied for osteoarthritis and depression. There is evidence that SAMe may help reduce the pain of osteoarthritis.

Some evidence is available for the use of SAMe for depression, fibromyalgia, and bile flow problems during pregnancy. SAMe has also been studied for its potential anti-inflammatory and pain-relieving effects. However, higher-quality studies are needed before conclusions can be made.

作為膳食補充品

研究表明，定期食用S-腺苷甲硫氨酸可抗抑鬱，肝髒疾病，和關節炎／關節疼痛。在美國市場上用SAM-e的名字按營養補品銷售，有改善情緒、保養肝髒和舒適關節的功效。 隨著營養補充品在大眾消費中增長，用於治療目的的S-腺苷甲硫氨酸亦有增加，特別是在1999年營養補充品健康及教育法通過以後。這部法令允許使用和分配S-腺苷甲硫氨酸做為一種可於櫃台出售的食物添加劑，並使其通過了FDA的限製性法令。S-腺苷甲硫氨酸已被很多研究性文章證明在治療上對肝部疾病、情緒失調與骨質疏鬆症有效。由於其結構上的不穩定性，S-腺苷甲硫氨酸的穩定的鹽形式成為其藥用的主要形式。盡管其穩定的鹽形式已經被製作出來，SAM仍然是易於分解的，因此其售賣者經常要求服食較可能被真正吸收的更多的劑量。廣泛報道的副作用是腸胃不適，但是有雙相障礙病史的人有發生狂躁症的風險。治療劑量的範圍是800毫克／天到1600毫克／天。