Department of Cell Biology
Harvard Medical School
240 Longwood Avenue
Boston, MA 02115
Junying Yuan received her Ph.D. in Neuroscience from Harvard University in 1989 and her undergraduate degree from Fudan University, Shanghai, China, in 1982. Dr. Yuan carried out her Ph.D thesis work at the Massachusetts Institute of Technology. She was first appointed as Assistant Professor at Harvard Medical School in 1992, when she became a Principal Investigator of the Cardiovascular Research Center at Massachusetts General Hospital. She joined the Department of Cell Biology in 1996 and was appointed a Professor of Cell Biology at Harvard Medical School in 2000.
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Junying Yuan | |
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Born | Shanghai |
October 3, 1958
Nationality | American |
Fields | Biology Cell death |
Institutions | Harvard Medical School |
Alma mater | Fudan University Harvard University Massachusetts Institute of Technology |
Doctoral advisor | H. Robert Horvitz |
Known for | Apoptosis research Necroptosis |
Junying Yuan (Chinese: 袁鈞瑛; pinyin: Yuán Jūnyīng, born October 3, 1958) is the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School,[1] best known for her work in cell death. Early in her career, she contributed significant findings to the discovery and characterization of apoptosis.[2][3] More recently, she was responsible for the discovery of the programmed form of necrotic cell death known as necroptosis.[4]
Junying Yuan was born in Shanghai, where she attended Fudan University following the revival of higher education after its suspension under the Cultural Revolution. She was among the first wave of students to attempt the newly revived National Higher Education Entrance Examination in 1977, coming in first of all students who attempted it in Shanghai.[5] She completed her Bachelors in Biochemistry in 1982, and was subsequently one of the first students admitted to doctoral study in the United States through the China-U.S. Biochemistry Examination and Application (CUSBEA) program, coming in second out of the 25,000 who attempted the CUSBEA in its first year.[6]
In the United States, she completed her PhD in Neuroscience(1989) at Harvard University under the supervision of MIT professor H. Robert Horvitz, where she endeavored to elucidate the molecular mechanisms behind programmed cell death in the nematode Caenorhabditis elegans. She identified the proteins ced-3 and ced-4 as drivers behind programmed cell death in C. elegans, and subsequently identified the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1.[2][3][7]
Junying Yuan established an independent lab at Harvard-affiliated Massachusetts General Hospital in 1989, immediately upon completion of her PhD.[6] Her initial efforts were directed towards providing evidence for the functional role of caspases in mediating mammalian apoptosis.[8][9] Her independent work at this stage provided the first insights into molecular mechanisms in mammalian apoptosis, which contributed significantly to the Nobel Prize in Chemistry won by her PhD supervisor, Robert Horvitz.[10]
In 1996, Yuan moved her lab to the Department of Cell Biology at Harvard Medical School's Longwood campus, where she continued her investigation into cell death. Her work delved further into programmed cell death and revealed a wide cohort of proteins involved in the regulation and consequences of apoptosis. Some notable work includes her discovery that BID cleavage by caspase-8 mediates mitochondrial damage in apoptosis,[11] and her discovery of caspase-11's role in regulating caspase-1-driven inflammation.[12]
In 2005, Yuan's group discovered a non-apoptotic form of programmed necrotic cell death, which they termed "necroptosis".[4] Other groups first observed that the stimulation of Fas/TNFR family of death-domain receptors(DR) activated a canonical apoptotic pathway; however, in many cell types, not only did caspase inhibition fail to inhibit cell death, as would be expected of canonical apoptosis, but stimulated cells experienced a form of cell death that more closely resembled necrosis than apoptosis.[13] Yuan's group conducted a chemical screen that identified a small molecule capable of inhibiting DR-driven cell death, necrostatin-1, and demonstrated necroptosis' role in ischemic neuronal injury, thereby positing a potential role for necrostatin-1 in stroke treatment. Her group then identified RIPK1 as the target for necrostatin-1,[14] thus implicating it as a key player in necroptosis. Yuan went on to identify and characterize members of the signaling network responsible for regulating necroptosis,[15] and continues to elucidate the mechanisms of necroptosis while exploring its potential as a target of therapeutic intervention. Necrosis was previously considered to be a form of passive cell death, forced in response to stress. This belief had driven an aversion towards developing therapeutic applications targeting necrosis. In demonstrating a form of programmed necrosis, Yuan's work revealed new avenues of treatment for an ever-increasing cohort of diseases where necroptosis is implicated.[16]
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袁均英 博士 在 哈佛 做過 正教授嗎?
| 推薦到群組
袁均英博士1982年畢業於複旦大學生化係,1989年獲哈佛大學神經科學博士,師從H.R.Harvitz教授。1992年聘為哈佛醫學院神經科學助理教授,1997年晉升為副教授,2000年起任哈佛大學醫學院終生教授,
我的理解是哈佛醫學院沒有 真正的 tenured 的。要靠基金養自己的。
哈佛醫學院成為正教授非常 困難,而且 正教授的工資還是要靠基金的。
有沒有知道的人願意解釋一下?
一些地方解釋袁博士是哈佛的正教授,大概基於 中國的 認識,大概認為 終身教授 肯定 正教授。
看 中國 現在的網站 比 資本主義 還要 資本主義。
http://www.erasmusmc.nl/radiologie/?lang=en
荷蘭最大醫學影像係的網站
https://strahlentherapie.charite.de
德國一大型腫瘤放療科的網站
xxx xxx 課題組 xxx lab Yan lab 這樣這樣的東東 反正我隻有在中國的網站 照片上看到過。公有財產怎麽可以寫上成 跟個人的一樣
我看到顏寧的實驗室顯微鏡 上 寫著 Yan lab.
我覺得是難以想象的
1 是公共財產 還是 私人財產?
2 為什麽不用 本國文字?
----- 非正式的網站:
http://tieba.baidu.com/p/3143876438
袁均英太厲害了 哈佛醫學院的正教授啊!!
通宵看號007: 哈佛大學的正教授啊,世界一流啊。
Interdisciplinary Research Center on Biology and Chemistry
-- 這個名字語法有沒有問題?