按照歐美的規矩，論文必須提及相關的事實來源，我看不到論文全文，不知道有沒有

來源: 波粒子3 於 2025-11-09 09:40:36 [] [舊帖] [給我悄悄話] 閱讀數 : (131027 bytes)

WE wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.). This structure has novel features which are of considerable biological interest.

A structure for nucleic acid has already been proposed by Pauling and Corey1. They kindly made their manuscript available to us in advance of publication. Their model consists of three intertwined chains, with the phosphates near the fibre axis, and the bases on the outside. In our opinion, this structure is unsatisfactory for two reasons : (1) We believe that the material which gives the X-ray diagrams is the salt, not the free acid. Without the acidic hydrogen atoms it is not clear what forces would hold the structure together, especially as the negatively charged phosphates near the axis will repel each other. (2) Some of the van der Waals distances appear to be too small.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

 

References

  1. Pauling, L., and Corey, R. B., Nature, 171, 346 (1953); Proc. U.S. Nat. Acad. Sci., 39, 84 (1953).

    Article ADS CAS Google Scholar 

  2. Furberg, S., Acta Chem. Scand., 6, 634 (1952).

    Article CAS Google Scholar 

  3. Chargaff, E., for references see Zamenhof, S., Brawerman, G., and Chargaff, E., Biochim. et Biophys. Acta, 9, 402 (1952).

    Article Google Scholar 

  4. Wyatt, G. R., J. Gen. Physiol., 36, 201 (1952).

    Article CAS Google Scholar 

  5. Astbury, W. T., Symp. Soc. Exp. Boil. 1, Nucleic Acid, 66 (Camb. Univ. Press, 1947).

  6. Wilkins, M. H. F., and Randall, J. T., Biochim. et Biophys. Acta, 10, 192 (1953).

    Article CAS Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Council Unit for the Study of the Molecular Structure of Biological Systems, Cavendish Laboratory, Cambridge. April 2. https://www.nature.com/nature

    J. D. WATSON & F. H. C. CRICK

Rights and permissions

Reprints and permissions

About this article

Cite this article

WATSON, J., CRICK, F. Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid. Nature 171, 737–738 (1953). https://doi.org/10.1038/171737a0

Download citation

  • Published

  • Issue date

  • DOIhttps://doi.org/10.1038/171737a0

 
 

This article is cited by

Comments

Commenting on this article is now closed.

  1. Charles Patrick Doncaster 

    The html version of this article is showing the wrong figure. See the pdf version for the correct figure.

所有跟帖： 

• 論文有提及照片來自富蘭克林，所以華生完全不是剽竊 -波粒子3- ♂ 給 波粒子3 發送悄悄話 (228 bytes) () 11/09/2025 postreply 09:46:16

請您先登陸，再發跟帖！