非常感謝您讓我聽到不同的聲音。
- SULFA ALLERGY
- Sulfonylureas contain a sulfonamide group in their structure
- The sulfonamide group is different from the one that is found in sulfa-based antibiotics
- Patients with a history of allergy to sulfa-based antibiotics may have a slight increase in risk of an allergic reaction to sulfonylureas
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- A cohort study in the NEJM looked at the risk of an allergic reaction to nonantibiotic sulfonamides in patients who had a previous reaction to a sulfa-based antibiotic
- The study found the following:
- Patients with a history of sulfa-based antibiotic allergy who subsequently took nonantibiotic sulfonamides (including sulfonylureas) had a 10% risk of having a reaction to the nonantibiotic sulfonamide
- In patients without a history of allergic reaction to a sulfa-based antibiotic, 1.6% had a reaction to a nonantibiotic sulfonamide
- In addition, patients with a history of sulfa-based antibiotic allergy had a 14% chance of having a reaction to a penicillin antibiotic. This finding led researchers to conclude that a history of allergic reactions in general may be more predictive of a reaction than reactions to any specific medication [15]
- StraightHealthcare analysis:
- Sulfonylureas may be prescribed to patients with a history of sulfa-based antibiotic allergy
- Patients should be aware that a cross-sensitivity reaction may occur with a risk of around 10%
- Patients with a history of severe reactions to sulfa-based antibiotics should avoid nonantibiotic sulfonamides if they can. If not, then the initial dosing should be done under medical supervision.
如果交叉反應的危險度達到10%，並不是罕見。尤其是第二次給藥，意味著我老公對Sulfonylureas過敏，就不應該再開Sulfonylureas藥物。我老公服用25天才出現過敏反應，明顯是IV型變態反應(遲發型變態反應），而不是I型變態反應。
