my hunch instinct told me that if you go basic, you'll get Nobel upon solving the basic inquiry like:
1) How to sense your direction (GPS grit cells)
2) How to sense oxygen (2019)
3) How to sense mechano-pressure (to be determined)
4) How to get IQ (intelligence)
5) How to live longer (teleromase, teleomere)
Discoveries led to candidate drugs for anemia and cancer.