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Thank you for the answer! I didn't notice that her category is NIW. In the case of regular EB not NIW, how the case is affected by the job change?

How is the 180 day's rule affecting this?

-As long as the I-140 sponsor does not withdraw the approved I-140 and USCIS does not make a decision on your I-485 in 180 days, your I-485 will be safe even if you change your job before its pending > 180 days. Then, after 180 days, your I-485 will be completely safe.

if the job tile and employer changed, should the I-140 still be valid?

Should the I-485 applicant informs USCIS of this change?

-Not need it.