The genetic diversity of SARSr-CoVs in wildlife and their potential risk of cross-species infection highlights the importance of developing a powerful animal model to evaluate the antibodies and antiviral drugs. We acquired the mouse-adapted strain of a bat-origin coronavirus named SMA1901 by natural serial passaging of rRsSHC014S in BALB/c mice. The SMA1901 infection caused interstitial pneumonia and inflammatory immune responses in both young and aged BALB/c mice after intranasal inoculation. Our model exhibited age-related mortality similar to SARS and COVID-19. Therefore, our model will be of high value for investigating the pathogenesis of bat SARSr-CoVs and could serve as a prospective test platform for prophylactic and therapeutic candidates.
研究病毒是為了對付病毒. 這個視頻說了那麽多,卻隻字不提原文白紙黑字寫的重要性
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研究病毒也不等於是為了對付病毒,還可以是以防疫為名,實質上是利用病毒製造病毒武器。掛羊頭賣狗肉。你完全忽略後一種可能?
-咲媱-
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09/25/2023 postreply
07:18:40
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為什麽要到偏遠地區的洞穴裏采集病毒然後做增益型實驗?為啥要增益?有啥好處?出了紕漏,你有能耐管控嗎?
-看客2010-
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09/25/2023 postreply
12:36:17
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這在公開的信息裏都有,你自己可以找,我不想浪費時間
-SwiperTheFox-
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09/25/2023 postreply
13:14:46
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用得著找嘛,看薩斯2.0就夠了。
-看客2010-
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09/25/2023 postreply
13:50:26
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你自己能回答你自己的問題嗎? 或者說你已經先入為主地預設了答案, 為什麽要來問我?
-SwiperTheFox-
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09/25/2023 postreply
13:53:10
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你問問你自己,你家族中的老人是不是鋼筋鐵骨百毒不侵特殊材料製成的?是,算額白說;不是,你看著辦。
-看客2010-
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09/25/2023 postreply
16:32:36