糖尿病心血管並發症防治的綜述-歡迎批評指正。

 

 Heart Fail Rev. 2014 Jan;19(1):113-21. doi: 10.1007/s10741-013-9379-6.

Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants.

Department of Physiology, Institute of Cardiovascular Sciences, Faculty of Medicine, University of Manitoba, St. Boniface Hospital Research, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada.

Abstract

Oxidative stress is considered to play an important role in the pathogenesis of diabetes-induced cardiovascular disease (CVD), which is invariably associated with abnormal blood lipid profile, insulin resistance and metabolic syndrome. Stress, smoking, high saturated fat intake as well as low fruit and vegetable intakes have been shown to increase oxidative stress and hyperlipidemia, which increase the predisposition of diabetic subjects to atherosclerosis, stroke and coronary heart disease. The oxidation of low-density lipoprotein by oxidative stress is essential for the development of atherosclerosis, and the reduction in oxidative stress as well as blood glucose and cholesterol is considered critical for the prevention of diabetes-induced CVD. Although epidemiological studies have demonstrated that vitamin C and vitamin E decrease the incidence of coronary heart disease, different clinical trials have failed to support the beneficial effect of these antioxidants. Nonetheless, it has been suggested that natural forms of these vitamins may be more efficacious than synthetic vitamins, and this may explain the inconsistencies in results. Antioxidants, N-acetyl-L-cysteine and resveratrol, have also been shown to attenuate the diabetes-induced cardiovascular complications. It has been indicated that the antioxidant therapy may be effective in a prevention strategy rather than as a treatment for CVD. The evidence presented here supports the view that cardiovascular complications in diabetes may be induced by oxidative stress and appropriate antioxidant therapy may be promising for attenuating the progression of diabetes-induced CVD

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各位大俠說說自己的高招: -tantema- 給 tantema 發送悄悄話 tantema 的博客首頁 (7 bytes) () 05/12/2014 postreply 07:46:56

關鍵在於,如何讓血管壁細胞獲取必需的能量(葡萄糖或酮體),不使細胞"餓死" -probiotic- 給 probiotic 發送悄悄話 probiotic 的博客首頁 (34 bytes) () 05/12/2014 postreply 08:48:21

"low carb,high fat"是治療糖尿病及並發症的唯一行之有效的措施 -probiotic- 給 probiotic 發送悄悄話 probiotic 的博客首頁 (35 bytes) () 05/12/2014 postreply 08:55:19

降糖化學藥物,不但用處不大(ACCORD研究),而且危害性很大 -probiotic- 給 probiotic 發送悄悄話 probiotic 的博客首頁 (132 bytes) () 05/12/2014 postreply 09:03:46

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