日本學者發表在JCO的DELTA試驗是對於IIIB期或IV期NSCLC且已接受一種或兩種治療方案的患者的。結果顯示，對於這些未根據EGFR狀態進行篩選的患者，與多西他賽治療組相比，厄洛替尼組的無進展生存期(progression-free survival，PFS)和總生存期(overall survival，OS)未見改善。
Abstract
Purpose To investigate the efficacy of erlotinib versus docetaxel in previously treated patients with advanced non–small-cell lung cancer (NSCLC) in an epidermal growth factor receptor (EGFR) –unselected patient population.
Patients and Methods The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), response rate, safety, and analyses on EGFR wild-type tumors. Patients with stage IIIB or IV NSCLC, previous treatment with one or two chemotherapy regimens, evaluable or measurable disease, and performance status of 0 to 2 were eligible.
Results From August 2009 to July 2012, 150 and 151 patients were randomly assigned to erlotinib (150 mg daily) and docetaxel (60 mg/m2 every 3 weeks), respectively. EGFR wild-type NSCLC was present in 109 and 90 patients in the erlotinib and docetaxel groups, respectively. Median PFS for erlotinib versus docetaxel was 2.0 v 3.2 months (hazard ratio [HR], 1.22; 95% CI, 0.97 to 1.55; P = .09), and median OS was 14.8 v 12.2 months (HR, 0.91; 95% CI, 0.68 to 1.22; P = .53), respectively. In a subset analysis of EGFR wild-type tumors, PFS for erlotinib versus docetaxel was 1.3 v 2.9 months (HR, 1.45; 95% CI, 1.09 to 1.94; P = .01), and OS was 9.0 v 10.1 months (HR, 0.98; 95% CI, 0.69 to 1.39; P = .91), respectively.
Conclusion Erlotinib failed to show an improvement in PFS or OS compared with docetaxel in an EGFR-unselected patient population.
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非小細胞肺癌的分類: http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/Patient/page1
There are several types of non-small cell lung cancer.
Each type of non-small cell lung cancer has different kinds of cancercells. The cancer cells of each type grow and spread in different ways. The types of non-small cell lung cancer are named for the kinds of cells found in the cancer and how the cells look under a microscope:
- Squamous cell carcinoma (鱗癌) : Cancer that begins in squamous cells, which are thin, flat cells that look like fish scales. This is also called epidermoid carcinoma.
- Large cell carcinoma (大細胞癌) : Cancer that may begin in several types of large cells.
- Adenocarcinoma (腺癌) : Cancer that begins in the cells that line the alveoli and make substances such as mucus.
Other less common types of non-small cell lung cancer are: pleomorphic, carcinoidtumor, salivary gland carcinoma, and unclassified carcinoma.
有關非小細胞肺癌的clinical trials情況可參見維基鏈接:
Non-small-cell lung carcinoma - Wikipedia, the free ...
