法國千人用羥氯喹和阿奇黴素治療新冠肺炎的結果

來源: 吃與活 2020-04-10 13:25:35 [] [博客] [舊帖] [給我悄悄話] 本文已被閱讀: 次 (3499 bytes)
本文內容已被 [ 吃與活 ] 在 2020-04-10 13:41:45 編輯過。如有問題,請報告版主或論壇管理刪除.
 
ABSTRACT
 
Background
 
In a recent survey, most physicians worldwide considered that hydroxychloroquine (HCQ) 
and azithromycin (AZ) are the two most effective drugs among available molecules against COVID-19. Nevertheless, to date, one preliminary clinical trial only has demonstrated its efficacy on the viral load. Additionally, a clinical study including 80 patients was published, and in vitro efficiency of this association was demonstrated.
 
Methods
 
The study was performed at IHU Méditerranée Infection, Marseille, France. A cohort of 1061 COVID-19 patients, treated for at least 3 days with the HCQ-AZ combination and a follow-up of at least 9 days was investigated. Endpoints were death, worsening and viral shedding persistence.
 
Findings
 
From March 3rd to April 9th, 2020, 59,655 specimens from 38,617 patients were tested for COVID-19 by PCR. Of the 3,165 positive patients placed in the care of our institute, 1061 previously unpublished patients met our inclusion criteria. Their mean age was 43.6 years old and 492 were male (46.4%). No cardiac toxicity was observed. A good clinical outcome and virological cure was obtained in 973 patients within 10 days (91.7%). Prolonged viral carriage at completion of treatment was observed in 47 patients (4.4%) and was associated to a higher viral load at diagnosis (p < 10-2) but viral culture was negative at day 10 and all but one were PCR-cleared at day 15. A poor outcome was observed for 46 patients (4.3%); 10 were transferred to intensive care units, 5 patients died (0.47%) (74-95 years old) and 31 required 10 days of hospitalization or more. Among this group, 25 patients are now cured and 16 are still hospitalized (98% of patients cured so far).  Poor clinical outcome was significantly associated to older age (OR 1.11), initial higher severity (OR 10.05) and low hydroxychloroquine serum concentration. In addition, both poor clinical and virological outcomes were associated to the use of selective beta-blocking agents and angiotensin II receptor blockers (P<0.05). Mortality was significantly lower in patients who had received >3 days of HCQ-AZ than in patients treated with other regimens both at IHU and in all Marseille public hospitals (p< 10-2).
 
Interpretation
 
The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.

所有跟帖: 

對啊,這正好是我之前一直持有的觀點,用藥越早越好。等到了重症肯定沒用了 -sinology- 給 sinology 發送悄悄話 sinology 的博客首頁 (290 bytes) () 04/10/2020 postreply 13:30:33

我這裏一直吆喝,給NIH和CDC寫EMAIL,結果 -sinology- 給 sinology 發送悄悄話 sinology 的博客首頁 (94 bytes) () 04/10/2020 postreply 13:31:48

重症現在用Remdesivir或者Actemra,都是三期臨床。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:01:06

重症才用已經沒用了。所有能感染的細胞都已經被感染了 ,藥還有啥用? -sinology- 給 sinology 發送悄悄話 sinology 的博客首頁 (203 bytes) () 04/10/2020 postreply 14:09:38

趕緊普遍采用吧,死人太多了! -dudaan- 給 dudaan 發送悄悄話 dudaan 的博客首頁 (0 bytes) () 04/10/2020 postreply 13:30:41

我這十多天前就已經開始用。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 13:47:31

+ 早用 -欲千北- 給 欲千北 發送悄悄話 欲千北 的博客首頁 (0 bytes) () 04/10/2020 postreply 13:54:12

現在用的劑量(600mg/天x10天),好像比中國的劑量大。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 13:55:33

對一般人沒用,輕症不給開藥。隻有醫院可以用。 -LingYuan- 給 LingYuan 發送悄悄話 LingYuan 的博客首頁 (0 bytes) () 04/10/2020 postreply 13:58:42

是,就是開了也拿不到藥。FDA到現在隻批準給住院病人使用。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:03:03

真是迂腐。。。 -viewfinder- 給 viewfinder 發送悄悄話 viewfinder 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:03:41

沒辦法,藥源不足。可以從中國寄,不需要處方,我的5天就寄到了。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:08:02

居然還讓寄藥, 還這麽快。 我的口罩到現在還收不到, 3月底寄的。你用的哪家快遞? -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:14:54

EMS -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:17:18

也是EMS, 我再等等。 -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:18:45

試試Tracking。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:19:49

天天tracking, 已經離開上海, 然後, 就沒有然後了。 -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:25:59

我是兩個星期前寄的,可能是運氣好。還有一個朋友用了九天。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:37:14

耐心等,飛機班次少,包裹要排隊。 -nowayitsover- 給 nowayitsover 發送悄悄話 nowayitsover 的博客首頁 (0 bytes) () 04/10/2020 postreply 17:07:15

是啊, 隻能耐心等。 我朋友特意買的最好的那種,一片心意, 很感激的。 -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 19:15:03

怕藥的副作用, 亂用造成不良後果。 -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:08:47

這個藥已經用了幾十年了,相對安全。當然現在的劑量要大得多,要有心電圖監護。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:12:59

副作用主要是EKG Q-T間期延長,嚴重可有室性心律紊亂可致命。再就是可逆的視野缺損。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:16:35

多謝老道釋疑. -OceanSound- 給 OceanSound 發送悄悄話 OceanSound 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:19:43

別客氣。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:40:03

已自備了,和阿奇黴素,硫酸鋅一起用大概效果更好 -小落- 給 小落 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:29:00

也是這麽想的,而且已經開始吃Zinc了。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:38:35

成人 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (559 bytes) () 04/10/2020 postreply 14:50:42

我看到的劑量要高很多,有症狀的要100-200毫克/天。那個紐約的神醫是220毫克/天。我現在是60毫克/每天。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:55:16

當然我的情況比較特殊。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 14:59:25

淨鋅量 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (578 bytes) () 04/10/2020 postreply 15:22:54

謝謝解釋。那這樣劑量就差不多了。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 15:33:31

鋅吃多了會不會中毒啊?我是每三天吃一片舌下含 預防用藥。 -lucy2008liu- 給 lucy2008liu 發送悄悄話 lucy2008liu 的博客首頁 (0 bytes) () 04/10/2020 postreply 15:35:54

很可能,必須小心。再等等別人的經驗,和專家的意見吧。 -老道- 給 老道 發送悄悄話 (0 bytes) () 04/10/2020 postreply 15:59:59

算一下實際含鋅量。標準安全劑量,每天50毫克。 -fuz- 給 fuz 發送悄悄話 fuz 的博客首頁 (0 bytes) () 04/10/2020 postreply 18:37:39

哈哈哈……再次挺川普! -纖風- 給 纖風 發送悄悄話 纖風 的博客首頁 (0 bytes) () 04/10/2020 postreply 14:48:46

This contradicts to today's WSJ article: Chinese Doctors Questio -street0120003- 給 street0120003 發送悄悄話 (15422 bytes) () 04/10/2020 postreply 15:00:52

這個報道是與多個國家的反饋不同 -纖風- 給 纖風 發送悄悄話 纖風 的博客首頁 (0 bytes) () 04/10/2020 postreply 15:12:00

現存藥可能僅是無藥時的權宜之計藥,不然大小醫藥公司花重金--see Apri 7's WSJ article -street0120003- 給 street0120003 發送悄悄話 (30206 bytes) () 04/10/2020 postreply 15:29:37

請您先登陸,再發跟帖!

發現Adblock插件

如要繼續瀏覽
請支持本站 請務必在本站關閉/移除任何Adblock

關閉Adblock後 請點擊

請參考如何關閉Adblock/Adblock plus

安裝Adblock plus用戶請點擊瀏覽器圖標
選擇“Disable on www.wenxuecity.com”

安裝Adblock用戶請點擊圖標
選擇“don't run on pages on this domain”