懷孕時吸入汙染空氣增加孩子神經母細胞瘤（癌症）的風險

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Environ Res. 2013 Nov;127:1-6. doi: 10.1016/j.envres.2013.09.002. Epub 2013 Oct 16.

An exploratory study of ambient air toxics exposure in pregnancy and the risk of neuroblastoma in offspring.

Heck JE¹, Park AS, Qiu J, Cockburn M, Ritz B.

Author information

• ¹Department of Epidemiology, Fielding School of Public Health, University of California, 650 Charles E Young Dr, Box 951772, Los Angeles, CA 90095-1772, USA. Electronic address: [e-mail].

Abstract

Little is known about the etiology of neuroblastoma, the most common cancer in infancy. In this study, we examined maternal exposure to ambient air toxics in pregnancy in relation to neuroblastoma in the child. We ascertained all cases of neuroblastoma listed in the California Cancer Registry 1990-2007 that could be linked to a California birth certificate, and controls were selected at random from California birth records. Average air toxics exposures during pregnancy were determined based upon measures from community-based air pollution monitors. The study included 75 cases and 14,602 controls who lived with 5 km of an air pollution monitor, and we additionally examined results for those living within a smaller radius around the monitor (2.5 km). Logistic regression was used to determine the risk of neuroblastoma with one interquartile range increase in air toxic exposure. Neuroblastoma risk was increased with higher maternal exposure to carbon tetrachloride (OR=2.65, 95%CI 1.07, 6.53) and polycyclic aromatic hydrocarbons (OR=1.39, 95%CI 1.05, 1.84), particularly indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene. Hexavalent chromium was associated with neuroblastoma at the 5 km distance (OR=1.32, 95%CI 1.00, 1.74) but not at the 2.5 km distance. This is one of the first studies to report associations between neuroblastoma and these air toxics.

© 2013 Elsevier Inc. All rights reserved.

所有跟帖： 

• 個人認為可能是四氯化碳和多環芳烴損害或延遲了新生兒的免疫係統的發育，無法靠自身的免疫力阻止視網膜母細胞瘤細胞繁衍。 -禦用文人- ♀ (0 bytes) () 03/05/2015 postreply 22:54:52

• 正常新生兒本身就存在視網膜母細胞瘤的變異細胞，到2歲以後這些視網膜母細胞瘤細胞會自動消失。 -禦用文人- ♀ (0 bytes) () 03/05/2015 postreply 22:58:00

• 因其他原因死亡的新生兒，在屍檢中常常被發現存在著視網膜母細胞瘤細胞。兩歲以後自動消失。 -禦用文人- ♀ (0 bytes) () 03/06/2015 postreply 09:37:36

• 這說明，新生兒的免疫係統本來就不健全。而空氣汙染可能起著妨礙新生兒免疫係統發育的作用。 -禦用文人- ♀ (0 bytes) () 03/06/2015 postreply 09:39:54

• 至少從這個現象可以得出一個結論，空氣汙染的確會增加癌症發病率。至於癌症的病因，不同的癌症具有不同的致癌因素。 -禦用文人- ♀ (60 bytes) () 03/06/2015 postreply 10:12:33

• 謝謝！ 是的空氣汙染孩子最受苦。 -誌在千裏- ♀ (0 bytes) () 03/06/2015 postreply 22:14:39