Paxlovid（nirmatrelvir 片劑；利托那韋片劑）是一種未經批準的產品，含有一種 SARS-CoV-2 主要蛋白酶（Mpro：也稱為 3CLpro 或 nsp5 蛋白酶）抑製劑和一種 HIV-1 蛋白酶抑製劑和 CYP3A 抑製劑，根據緊急使用授權頒發 (EUA) 獲得美國食品和藥物管理局批準，用於治療成人和兒科患者（12 歲及以上，體重至少 40 公斤）的輕度至中度冠狀病毒病 2019 (COVID-19)，直接結果呈陽性 嚴重急性呼吸係統綜合症冠狀病毒 2 (SARS-CoV-2) 病毒檢測，以及進展為嚴重 COVID-19（包括住院或死亡）的高風險人群。
Paxlovid 的副作用是什麽？
Paxlovid 的副作用包括：
口味的變化，
腹瀉，
高血壓（高血壓），和
肌肉疼痛
嚴重的眼部症狀，如視力突然下降、視力模糊、隧道視力、眼睛疼痛或腫脹，或在燈光周圍看到光暈；
嚴重的心髒症狀，例如快速、不規則或劇烈的心跳； 在你的胸膛飄動； 呼吸急促; 突然頭暈，輕鬆，或昏倒；
劇烈頭痛、意識模糊、言語不清、手臂或腿無力、行走困難、失去協調、感覺不穩、肌肉非常僵硬、高燒、大量出汗或顫抖。
Side Effects of Paxlovid (Nirmatrelvir Tablets and Ritonavir Tablets), Warnings, Uses (rxlist.com)
Paxlovid (nirmatrelvir tablets; ritonavir tablets) is an unapproved product that contains a SARS-CoV-2 main protease (Mpro: also referred to as 3CLpro or nsp5 protease) inhibitor and an HIV-1 protease inhibitor and CYP3A inhibitor issued under Emergency Use Authorization (EUA) by the U.S. Food and Drug Administration for the treatment of mild-to-moderate coronavirus disease 2019 (COVID-19) in adults and pediatric patients (12 years of age and older weighing at least 40 kg) with positive results of direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral testing, and who are at high risk for progression to severe COVID-19, including hospitalization or death.
What Are Side Effects of Paxlovid?
Side effects of Paxlovid include:
- changes in taste,
- diarrhea,
- high blood pressure (hypertension), and
- muscle aches
Seek medical care or call 911 at once if you have the following serious side effects:
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
