https://www.cancer.org/cancer/colon-rectal-cancer/treating/by-stage-colon.html
Most people with stage IV cancer will get chemo and/or targeted therapies to control the cancer. Some of the most commonly used regimens include:
FOLFOX: leucovorin, 5-FU, and oxaliplatin (Eloxatin)
FOLFIRI: leucovorin, 5-FU, and irinotecan (Camptosar)
CAPEOX or CAPOX: capecitabine (Xeloda) and oxaliplatin
FOLFOXIRI: leucovorin, 5-FU, oxaliplatin, and irinotecan
One of the above combinations plus either a drug that targets VEGF, (bevacizumab [Avastin], ziv-aflibercept [Zaltrap], or ramucirumab [Cyramza]), or a drug that targets EGFR (cetuximab [Erbitux] or panitumumab [Vectibix])
Cetuximab alone
Panitumumab alone
Regorafenib (Stivarga) alone
Trifluridine and tipiracil (Lonsurf)
The choice of regimens depends on several factors, including any previous treatments you’ve had and your overall health.
If one of these regimens is no longer working, another may be tried. For people with certain tumor changes in the MMR genes, another option after initial chemotherapy might be treatment with an immunotherapy drug such as pembrolizumab (Keytruda) or nivolumab (Opdivo).
5-FU and leucovorin, with or without a targeted drug
Capecitabine, with or without a targeted drug
Irinotecan, with or without a targeted drug
