麻醉會影響老人的記憶力

好像有爭議，大家有興趣自己google了，
http://www.dailymail.co.uk/health/article-2358493/How-general-anaesthetic-harm-memory-life-Research-finds-quarters-older-patients-develop-memory-loss-surgery.html

How a general anaesthetic could harm your memory for life: Research finds that three quarters of older patients develop memory loss after surgery

• Significant numbers of patients have long-lasting behaviour changes
  
• A study shows that general anaesthesia may increase the risk of dementia
  
• And it could even weaken the immune system
• The longer the surgery and the older you are, the more you're at risk
  

By Lucy Elkins

Published: 16:37 EST, 8 July 2013 | Updated: 16:37 EST, 8 July 2013
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Significant numbers develop post-operative cognitive decline (POCD), suffering from memory loss and behaviour changes; they're also just not as sharp as before. This can last weeks or even months. Some believe it can be permanent.

But this is not the only potential effect. Recently it's been suggested that general anaesthesia may also increase the risk of dementia - possibly by causing inflammation in the brain.

Other studies have suggested it weakens the immune system.

Researchers are also looking at the possibility that in the under-threes it may lead to the death of brain cells and increase the risk of developing memory and learning difficulties.

Doctors still don't fully understand how general anaesthesia works, says Dr Robert Sanders, an honorary lecturer at the department of anaesthesia at University College London Hospital.

'General anaesthesia seems to mimic sleep, but it's more complex than that, as patients don't wake up during surgery as they would if merely asleep.'

Anaesthetic slows down the electrical activity of the brain.

'Brain cells communicate with one another with electrical impulses,' says Professor Jaideep Pandit, a consultant anaesthetist at the John Radcliffe Hospital in Oxford.

'We know that a general anaesthetic suppresses that electrical activity.

'Recently it's been suggested that general anaesthesia may also increase the risk of dementia - possibly by causing inflammation in the brain.'

'People are normally put under using propofol, given intravenously. It works quicker than a gas would (a gas is then used to keep them asleep).

'Some people are groggy in the minutes and hours after they wake up - we believe because the electrical activity of their brain has to speed up again,' says Professor Pandit.

Yet a recent French study suggests some people could have longer-term effects. An analysis of data from more than 9,000 men and women aged over 65 found those who'd had a general anaesthetic in the previous two years were more likely to develop dementia, including Alzheimer's disease.

One theory is that the general anaesthesia may contribute to brain inflammation and thus encourage the production of amyloid plaques, which are linked to Alzheimer's disease.

But the suggestion is hotly contested.

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• 同意；麻醉甚至還影響中年人的記憶力 -halfdummy- ♂ (0 bytes) () 09/12/2014 postreply 18:40:38