A letter to Bill gates, Solve Medical Dilemma by TCM Philosophy

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A letter to Bill gates, Solve Medical Dilemma by TCM Philosophy Revolutionizing Western Medicine 

     Frank (Hongde) Li, June 26, 2023 in Canada 

      https://blog.creaders.net/user_blog_diary.php?did=NDY1MDI2

This was a part of sent email to Bill Gates in June 16, 2023 via Bill & Melinda Gates Foundztion [e-mail] and Beijing Municipal Government and Tsinghua University Global Health Drug Discovery Institute (GHDDI) [e-mail]; which email was excert-update revised form Feb. 2021 article The mechanism of human intelligence and the humanization of social governance.   http://www.kwcg.ca/bbs/blog-61910-15926.html 

In playing China’s 2500 years old two players’ board game Go, computer program AlphaGo beats human professional Go player revealed the mechanism of human intelligence; it acts as a Robot by acquired knowledge as software driver; so that human nature or intelligence is in lifelong reshaping. The defect brain structure; the wrongful knowledge; the improer philosophy; the toxic ideologies; especially the inhuman life experience will make people wrongful thinking and behaving; which made people in different quality; some people are in the inhuman mentality in taking wrong as right. 

Philosophy affects the way of people in thinking and therefore affecting the way of people in behaving; and which will affect people in thinking and pursuing of the intellectual engine in driving the outcomes of people in social activities; and which will affect the quality of its accompanied culture, or history, or civilization (they were accompanied, not purposefully created). Medicine was the main part of a civilization; so that it can demonstrate the humanized level of a civilization.

Human life is complex system in dynamic developing under the impact of unknown or known but uncontrollable factors; so that it must be regarded as Chaotic System to deal with by Chaos Theory, in this concern, the Macro dialectic philosophy Daoism guided TCM is suitable for human life; while the Micro precision-seeking philosophy Reductionism guided Western medicine is in the opposite.

         Contents & Summary

       A Letter to Bill Gates & Melinda Gates

3... Stop profiteering; handy diets, diet supplements and chemicals will be god medicine

3.1... The process of anti-pandemic Covid-19 is a psychotic attack of social diseases

3.2... Dialectic philosophy Daoism guided TCM is suitable for human life

3.2.1... The Physiology Basis of the restoration of Yin and Yang balance .

3.2.2... The Psychological Basis of the restoration of Yin and Yang balance

3.2.3... The Pharmacological basis of the compound medication of TCM

3.2.4... Modern study proved the existence of acupuncture meridians

3.2.5... The mechanism of TCM cured Covid-19 patients in less deaths and complications

3.3... Precision seeking Reductionism made Western medicine unsuitable for human life

3.3.1... Some officials and medical experts acted as the killer aider of the Covid-19 virus .

3.3.2... Ban the use of HCQ caused over 50% of global 6.5 million Covid deaths

3.3.3... Ban the use of Remdesivir caused over 83% of global 6.6 million Covid deaths

3.3.4... Ban the use of Lianhua Qingwen capsule of TCM caused 90% unnecessary death

3.3.5... Without proper medications made tragedy of Covid deaths in Britain

3.3.6... French Professor Didier Raoult mistreated by Western medicine dehumanized people

3.3.7... It is the globally distributed medical experts in misleading WHO wrongful directing

3.3.8... The genetic studies and the products can never be benefit; but harm human life

3.4... Rationalize medical philosophy to optimize disease treatment and medication

3.4.1... Drug concept revolution:The electronegativities of atoms in polar chemicals can be used for therapy.

3.4.1.1... Vinegar keeps me a healthy teeth and away from snoring and apnea

3.4.1.2... Corrosive injury of vinegar is able to self-heal without complications

3.4.1.3... Vinegar has wide range of physiological and pharmacological functions

3.4.1.4... Hypochlorous acid will be potential medication by electronegativities of oxygen and chlorine atom

3.4.1.5...Chlorine dioxide will be potential medication by electronegativities of Oxygen atom and Chlorine atom

3.4.1.6...NaF reduced mortality percentage of influenza virus H0N1 in mice

3.4.1.7...The physiological function for therapeutic potential of carbonate ion in calcium carbonate

3.4.2... Drug concept revolution: The synergistic effect of compound medication will be god medicine

3.4.3... Drug concept revolution: Melatonin will be the God medicine by perfecting nutrition processing

3.4.4... Drug concept revolution: The Orthomolecular Medicine is best drug sources

3.4.4.1... Vitamin C has multi-therapeutic effects that cover the most of diseases

3.4.4..2... Vitamin B3

3.4.4.3... My personally tested the flush of the side effect of Vitamin B3

3.4.4.4... Vitamin D

3.4.5... Honey has multi-therapeutic effects that cover the most of diseases

3.4.6... Suggested combo for curing Covid-19 by handy available diets and medicinals

3.4.7... Some ideas for quickly returning pre-pandemic life

3.4.7.1... The treatment of Covid-19 by honey and vinegar

3.4.7.2... The prevention of Covid-19 by vinegar and hypochlorite

3.4.7.3... Confirm the safety of hypochlorite by body test of disinfection operators

3.4.7.4... Government must force the study in the cheaper approaches

3.5... Develop new drug based on brand new drug concept

3.6...The inhalable antiviral volatile may be the only hope for saving livestock industry

Note, since the references used in article were mostly from online, now, most of the original links have lapsed and it is no longer possible to give the sources of the references.

A letter to Microsoft Bill Gates for revolutionizing medicine

Emailed in June 16, 2023

To Melinda Gates & Bill Gates

Bill & Melinda Gates Foundation

Seattle, Washington

[e-mail]; [e-mail]; [e-mail]

Dear Melinda Gates & Bill Gates

Yesterday June 15, 2023, I found report that: “The Bill & Melinda Gates Foundation announced a renewed collaboration with the Beijing Municipal Government and Tsinghua University to support the Global Health Drug Discovery Institute (GHDDI) in its efforts to improve health outcomes worldwide through lifesaving therapies for infectious diseases.”

Also I learnt that Bill Gates was in Beijing China and made remarks at the Global Health Drug Discovery Institute Beijing China.

This email is suggestion that Bill & Melinda Gates Foundation should update the mission towards solve the problem from root level in the philosophy politically and medicinally.

Firstly, it is to rescue human world from the ruining of low quality politicians, who are abusing Gov-power provoking Russia to beatomic havocked; otherwise any effort is pointless. 

Secondly, it is rescue economy, as current way of the childish play of individual politicians, the world will be ruined by the shortage of life necessaries; otherwise any effort is pointless.    

Thirdly, it is to develop lifesaving therapies for infectious diseases by updating medical philosophy by integration of the philosophy of TCM; otherwise any effort will be less effective.   

In attached article, I made some discussions for reference.

I sincerely wish success in endeavors of Bill & Melinda Gates Foundation

Hope for good news

Yours sincerely

Frank (Hode) Li, June 16, 2023 

Bill Gates may help developing medicine once for all

May 21, 2023, article Disease X is coming, and with it the next global pandemic, scientists warn reports that Ebola, HIV-AIDS, rabies and COVID-19 have all spilled from animals to humans — and show us the kind of health threat we must be ready to fight. It is not an exaggeration to say that there is potential of a Disease X event just around the corner. As the world eases back to normalcy following three years of COVID-19, the scientific and public health community is already preparing for the next serious outbreak or pandemic. They just don’t know what the disease will be yet.

Scientists have estimated that 1.67 million yet-to-be-discovered viruses exist in mammals and birds, and about half of them have the potential to spill to humans. As far back as 2018, the World Health Organization (WHO) gave this unknown future outbreak a placeholder name: Disease X. It represents the “knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease,” the WHO explained. One year after that designation, COVID-19 was identified as the first in the mysterious category that scientists had warned about.

Today, more infectious outbreaks seem inevitable.

All of the 1.67 million unknown viruses belong to about 25 viral families; already, scientists have identified 120 viruses from these families that pose a potential risk to humans. Since it’s virtually impossible to prepare for each viral pandemic threat. So, humans ,ust act to have much more investment in basic research, and preparedness and understanding of biology and understanding of the threats.

Considering that three out of four new outbreaks originate in wildlife, scientists have a fair idea that the places where new emerging diseases are most likely to start are countries where there’s a lot of wildlife diversity … means tropical and subtropical countries.

May 21, 2023, article WHO Chief Hopes For 'Historic' Pandemic Accord reports that: A new pandemic accord under negotiation must be a "historic agreement" marking a dramatic shift in the approach to global health security after the Covid crisis, the WHO chief said Sunday.

A new pandemic accord is meaningful, but also it means that a large sum of living money for people will be used in places that have nothing to do with survival necessities, and even used to develop useless projects for economic plunder; such as genetic products.

The 20 million Covid deaths gave us a lesson that, in the practice of leading Covid-19 epidemic prevention and control, the role of national and international health authoritative organizations were more bad than good; because of, they keep endorsing the wrong conclusions of they hired consultant medical experts, increasing the deceitfulness, and helping the virus kill more people.

Moreover, they continue to warn that this empirical method is not safe because it is not scientific, and that empirical method is not safe because it has not been scientifically verified; by such hearsay scaring people dare not use effective empirical methods to self-help; otherwise, the epidemic will not deteriorate to out of control. Badly; they misled wasted too much life saving money on greedy genetic products.

By such childish way; they help epidemic lasting for three years, and now it is in ongoing actually; which have completely destroyed the economy and destroyed the foundation for human survival.

We need to explore a solution once for all to stop the huge spending on meaningless childish play with making more deaths; thereby make money used on essential survival necessities. Also make people self-cure and maintain health with cheap condiments and natural medicines in handy available, to reduce the dependence on increasingly expensive and unaffordable hospitals and medicines.

Many reports show that pandemic COVID-19 is in continuously ongoing and the Covid virus is still killing and changing; while other viruses endlessly emerging, we need to look for a solution from the root of the revolution in medical philosophy.

Human life is complex system in dynamic developing under the impact of unknown or known but uncontrollable factors; so that it must be regarded as Chaotic System to deal with by Chaos Theory, in this concern, the Macro dialectic philosophy Daoism guided TCM is suitable for human life; while the Micro precision-seeking philosophy Reductionism guided Western medicine is in the opposite.

Philosophy Daoism dialectically views the universe as a system of the unity of opposites, which is composed of many components - subsystem with own feature of unity of opposites in the state of dynamic balance. The two sides of unity of opposites are interdependent as the part of each other’s existence. Dao embodies the harmony of the unity of opposites by regulating the natural processes and nourishing the balance. By Yin and Yang represent the two opposites.

TCM is developed by taking the principles and terminology of Daoism, views human body as organic whole of the unity of opposites. In thousand years ago, TCM has recognized that psychological factors are in decisively affecting the development of disease with the belief that disease treatment is seven-tenths in psychotherapy, only three-tenths in medication. A well balanced human body can handle with diseases, so that disease treatment is to restore Yin and Yang balance by natural therapies and medicinals.

Philosophy Reductionism believes that the whole of reality consists of a minimal number of parts. The complex system can be decomposed into simple independent units to understand the whole.

Western medicine develops by taking Reductionism as guidance in viewing human life as the inanimate assembly of lifeless parts by infinitely subdividing body as independent micro unit as genes or proteins to study the development of diseases and by looking for killing and genetic patching as treatment in ignoring that psychological factor in decisively affecting the development of diseases. In 2008, a study of crossing four disciplines reveals that Stress Causes Everything from gums to heart and make susceptible to everything from common cold to cancer.

The disease treatment of Western medicine is to look for killing in accurate as that of precise sniper rifle; but it is unable to make precise bullets by developing synthetic drugs; due to that any disease is syndrome with multi-lesions; such as, though the virus Covid-19 is the single cause of the disease; but it infected people are in the disease of syndrome in multi-lesions mutually influenced developing. Such as:

 Sept. 9, 2022, article Long COVID's link to suicide: scientists warn of hidden crisis reports that Long COVID has more than 200 symptoms - some of which can resemble other illnesses - from cognitive impairment to heart palpitations; which caused suicidal thoughts among the people with long COVID. Article said that an 18 months Long Covid sufferer Taylor said: "I can hardly do laundry without complete exhaustion, pain, fatigue, pain all up and down my spine. World spinning dizzily, nausea, vomiting, diarrhea; it seems I say stuff and have no idea of what I'm saying,"

Obviously, the treatment of Western medicine will less help for such a multiple symptoms at the same time.

We must revolutionize medical philosophy by philosophy Reductionism of Western medicine integrating the philosophy Daoism of TCM to make complementary advantages of each others; then from viewing human life as lifeless assembly to view human life as emotional whole; then the concept of disease treatment will be rationalized from looking for killing and genetic patching to make restoration of Yin and Yang balance; and the concept of drugs will be rationalized from looking for developing synthetic one with side effect to look for the multiple combination of existing medicinals. Then the multiple medicinals will be able to cure multi-lesions as that of shotgun hits multi-targets.

Obviously, the effective cure for Covid infections and those as WHO Director-General Tedros indicated prolonged aftereffects of COVID-19 infections of more than 200 symptoms will come from physical restoration by compound medication of TCM.

If we treat disease by restoration of Yin and Yang balance; then the daily diets, diet supplements and even some chemicals will be god medicine to make breakthrough in the treatment of the chronic diseases; such as Alzheimer's disease, then people will be able to self-help in disease treatment; thus, live a happier life with lesser economic burden on health care by getting rid of fully relying on the expensive hospitals and synthetic medications to reduce the reliance on public healthcare; thereby relieving the dilemma in healthcare of over crowed hospitals and unbearable high price in drugs; thereby reducing the pressure of government.

We can develop new natural medicinal additives as daily diet to regulate human body keeping in optimal healthy state, thereby reduce the occurrence of sicknesses, as well, the increase in demand of natural medicinal resources will promote the development of related industries in herbs’ planting and processing with the creation of employment and revenue.

Then it is easy to kill inhaled viruses in regardless of the type of virus by inhaling antiviral air in daily once and cure those infected people by daily diets and chemicals in polar molecule with strong electronegativity of polar bond of atom.

I infer that daily once inhales vinegar or/and hypochlorite mixed antiviral air will be able to kill any kind of airborne viruses that may inhaled into respiratory tract; also exchange through the lungs to enter blood circulation to produce systemic therapeutic effects to cure potential existing diseases. Meanwhile, improve physiological indicators to enhance physical health.

Such as vinegar, the therapeutic effects almost cover all of the diseases, except not studied; so it said that vinegar is cure for all. Lab studies proved that drinking water diluted vinegar can increase the immune cells in the blood of mice and decrease the fat of abdominal and intestinal wall of chicks. Also it benefits to Arthritis, Hypertension, Diabetes, and so on. Please Google; you will be surprised by the results that vinegar is a typical God Medicine.

Human beings need inhaling oxygen is because of the divalent electronegativity of oxygen atom. According to this, I infer that other atoms and chemical compounds with function to produce electronegativity will have similar effect, such as, F, Cl, N, Br, I; hydroxide radical, carbonate radical, and sulfate radical, and so on. The key is at study how to medicinal use them safely; rather than simply yelling unscientific or unproven.

The electronegativity is a measure of an atom's ability to attract shared electrons to itself; so that the chemical effect of electronegativities of Oxygen atoms are able to kill viruses and bacteria by impacting their covalent bonded structure; while the electronegativity is able to stimulate the physiological activities of covalent bond structured human body of tissue and organs to produce full cover therapeutic effects without formation of drug resistance.

According on available studies, I firmly believe that daily diets, diet supplements and some chemicals will be god medicine to cure and prevent the most of diseases; especially make breakthrough in the treatment of the chronic diseases; such as Alzheimer's disease, then people will be able to self-help in disease treatment; thus, live a happier life with lesser economic burden on healthcare by getting rid of the reliance on public healthcare; thereby relieving the dilemma in healthcare of over crowed hospitals and unbearable high price in diseases treatment.

2.1... I propose potential studies for revolutionizing medicine

Unlike the synthetic drugs, which have a single effect with side effects; the medicinals below have multi-therapeutic function; at the time kills pathogenic agents, also are able to comprehensively enhance physical health indicators, such as, increase immune cell counts, balance blood sugar and blood lipids, heal underlying diseases, and more.

Such as, if we use hypochlorous acid mixed inhalable antiviral air, it will be not only able to prevent all kind of airborne infectious diseases; but also significantly, by the exchange through the lungs to enter the blood circulation; it will achieve the effect of comprehensive treatment of underlying diseases; especially chronic degenerative diseases, such as, Alzheimer's, diabetes, AIDS and so on; while also are able to comprehensively enhance physical health indicators.

2.1.1... Confirm synergistic effect that produced by multi-combining medicinals

Studies show that best medication will come from the multi-combination of the medicinals; in regardless of synthetic or naturals; the more medicinals combined the stronger therapeutic effect the lower side effect.

Any disease is a syndrome of multiple organ and tissue damaging in mutually influence-developing. The best treatment should be able to prevent the deterioration of multiple damages at the same time. A large number of drug ingredients in the compound medicine are as if a large number of projectiles in a shotgun can hit multiple targets and heal the multiple damages at the same time. However, the medication method of Western medicine runs counter to this.

2.1.2... Confirm chemicals that compose of atoms in strong electronegativities for medicinal use

Electronegativity is able to destroy the covalent bonded structure to kill viruses and bacteria; while stimulate covalent bonded human tissue and organs to produce full cover therapeutic effects without formation of drug resistance.

The thousands of years use as condiment and medicine; vinegar has been proven safe for internal use. And modern studies reveal that the therapeutic effects of vinegar almost cover all of the diseases. The LD50 of sodium hypochlorite is 330g/50kgLD50 in double safer than that of vinegar in 165g/50kg.

As my long experience for curing flu of fever and cough, oral 1g vinegar/50kg in once can achieve immediate effect; which is far-far to the amount of 165g/50kg of LD50. According to LD50, I infer that the therapeutic effect of Hypochlorous acid will be much stronger and safer than that of vinegar.

Suppose that we inhale Hypochlorous acid produced inhalable antiviral air in daily once, it will be not only able to prevent any type of virus caused airborne infectious diseases; but also it will be able to cure diseases as that of vinegar did; while promoting health keeping to reduce the occurrence of diseases.

I infer that Hypochlorous acid will be effective on such kind drug-resistance; in both internally and externally.

May 11, 2023, in U.S., At least 2 cases of drug-resistant ringworm infections found in the U.S., CDC says: Micrograph of the fungus Trichophyton rubrum, which causes ringworm. A drug-resistant species of the Trichophyton fungus was recently detected in the U.S.CDC.

2.1.3... Confirm Melatonin optimizing gut microbiota as medicinal use

My experience shows that regularly taking Melatonin will be able to permanently optimize our digestive system - Gut to perfect nutrition supply by optimizing Gut microbiota into the optimal state.

2.1.4... Confirm vitamins and minerals of Orthomolecular Medicine as best drug sources

The orthomolecular medicine will be the best treatment for the most of diseases; the key is at the high concentration in blood, which needs intravenous infusion in use and megadose in g/kg body weight.                                                                                                                 

2.2... Study teams

It is best to have two or three teams conduct the same research at the same time to confirm the reliability of the research results.

2.2.1... Peking University has best study team

Please Microsoft Bill Gates to support the study.

The respiratory tract plays decisive role in transmission of airborne infectious diseases

The fact is clear, due to the breathe Inhaling and exhaling air; the respiratory tract is the receiver, replicator and a spreader of the Covid-19 virus.

Studies revealed that mammalian respiratory tract with the help of the ACE2 receptor works as the primary host for Covid-19 virus invading, replicating and spreading with days’ incubation period.

In this concern, as earlier as Jun 2, 2020, the team of Professor Maosheng Yao at Peking University has published series studies in talking about the Exhaled breath is a significant source of SARS-CoV-2 emission to warn that without the need of coughing and sneezing, the normal breathing of the symptomatic or asymptomatic infected person can spread the virus. I Googled study reports of the team of Professor Maosheng Yao on the airborne transmission of Covid-19 as below.

Jun. 02, 2020, Detection of SARS-CoV-2 in Exhaled Breath from Patients Ready for Hospital Discharge.

Jun. 02, 2020, Exhaled breath is a significant source of SARS-CoV-2 emission.

Jun. 24, 2020, Breath-borne VOC Biomarkers for COVID-19

Aug. 08, 2020, COVID-19 patients in earlier stages exhaled millions of SARS-CoV-2 per hour

Aug. 20, 2020, On airborne transmission and control of SARS-Cov-2

Badly, the virus from normal breathing has an instantaneous propagation speed. Such as, on a windless day, my neighbor started car in 10 meters away; the sound of engine and the smell of exhaust arrived at the same time. People who sprayed too much perfume walked 10 meters away; the smell of the perfume arrived at almost instantly.

The understanding up to this day, the Covid-19 virus receptor gene angiotensin-converting enzyme 2 (ACE2) seems distribution in many part of human body in contributing the virus’ replication. However, the excretion outlet of the replicated virus is different, and the harm is also different.

Urine and feces are excreted into the sewer; the pollution is easy controllable. However, if the virus discharged into the atmosphere is difficult to control and which is the main channel of the Covid-19 virus transmission.

The natural breathing of people makes respiratory tract as a perfect target area for preventing and treating Corona-19 infection. We may easily kills the possible virus by inhalable antiviral air in the time of they just invaded in during the days’ incubation period before they start to replicate.

Vinegar and hypochlorous acid would be the safest broad-spectrum inhaled disinfectants. The studying on the effectiveness and how to effective use require precise measurements of concentration in the air; which need Bioaerosol technology and equipments.

In this concern, the team of Peking University Bioaerosol Laboratory will be best candidate.

Contact:

Peking University Bioaerosol Laboratory,

http://scholar.pku.edu.cn/myao

http://www.yaopkulab.com

Tel: [phone]; Email: [e-mail]

Also, Peking University has many laboratories and hospitals, experienced researchers and experienced doctors; so that it has the resources to complete all research projects above.

2.2.2... French Professor Didier Raoult

French Professor Didier Raoult is a French physician and microbiologist specializing in infectious diseases; He once mistreated by own countrymen. 3.3.6... French Professor Didier Raoult mistreated by Western medicine dehumanized people.

Professor Didier Raoult has personal and academic qualifications to lead this research.

2.2.3... Former German chancellor Dr. Angela Merkel

Former German chancellor Dr. Angela Merkel who is the most rational politicians in contemporary world; she once said that “tear down walls of ignorance and narrow-mindedness, for nothing has to stay as it is,” to get rid of the state of “describe lies as truth and truth as lies.”

But the rational Dr. Angela Merkel who was also mistreated by own countrymen as that of Professor Didier Raoult. My suggestion is that to grant Dr. Angela Merkel supersizing a German team to participate the study. 

3... Stop profiteering; handy diets, diet supplements and chemicals will be god medicine

3.1... The process of anti-pandemic Covid-19 is a psychotic attack of social diseases

Faced with helpless reality, Jan 24, 2022, the resigned White House Coronavirus Adviser, Professor Scott Atlas expressed disappointed feeling by the speech the tragedy of SARS2 pandemic and the need to restore trust in the country’s vital institutions in YouTube video The SARS2 Pandemic: Will Truth Prevail: “the management of this pandemic has left a stain on many of America’s once noble institutions, including our elite universities, research institutes and journals, and public health agencies. Among the most damaged has been the harm to the essential functioning of science, research, and debate.”

Obviously, Western medicine is not only failed in both of prevention and treatment of Covid-19; but also it has dehumanized to many people in the psychotic state of taking wrong as right and promoting bad for good.

No one would deny that the process of anti-pandemic Covid-19 is a psychotic attack of social diseases from European based Western Individualistic Civilization; in which cultured too many people without collective sense; especially medical experts; for greedy genetic play, they avoid to study cheaper way to end pandemic; while it bred Western medicine is not suitable for human life in philosophical basis; since 1955 placebo effect was found, it has been in killing people by training people to kick away the effective drugs that used in combo by double blind clinic trial testing in single.

When coping with Covid-19; the fatal harm of Western medicine is at that it distorting people addicted in vaccination for self-protection without stopping the replication of virus; so that the virus freely fatal mutates. Only TCM is able to help to return to pre-pandemic life by compound medication restoring physical balance to replace genetic patching.

Human life is complex system in dynamic developing under the impact of unknown or known but uncontrollable factors; so that it must be regarded as Chaotic System to deal with by Chaos Theory, in this concern, the Macro dialectic philosophy Daoism guided TCM is suitable for human life; while the Micro exact-seeking philosophy Reductionism guided Western medicine is in the opposite.

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3.2... Dialectic philosophy Daoism guided TCM is suitable for human life

 

Philosophy Daoism (China, 500-400BC) dialectically views the universe as a system of the unity of opposites, which is composed of many components - subsystem with own feature of unity of opposites in the state of dynamic balance. The two sides of unity of opposites are interdependent as the part of each other’s existence. Dao embodies the harmony of the unity of opposites by regulating the natural processes and nourishing the balance of the opposites. By Yin and Yang represent the two opposites in symbiosis coexists, one ebbs and another grows, and vice versa.   

Therefore, the universe is a system that is in the state of dynamic balance through continuous self-balance. 

                                            

 

Yin often represents the negative, the female, dark, cloudy, cold and the Earth, etc.. Yang represents the positive, the male, bright, sunny, hot, and the Heaven, etc. They are in accompanying coexistence; there would be no male without female, no bright without dark. 

The eyes of white fish are black, and the eyes of black fish are white, which means that there is yang in yin, and yin in yang, and they are not absolute. It means that when people look at things, they should not be absolute also. Everything is constantly evolving and in a state of constant change.

Due to the Daoism is developed by observing the real world in geography, astronomy, society and daily life, rather than by idealistic fantasy, so that the primitive dialectical view generated in thousands of years ago is well coinciding with the objective world and modern science in nature world.  

The dialectical thinking is very important when dealing with the social contradiction. Daoism is best matching with both objective reality and subjective reality without false illusions. Therefore, the Daoism is perfect rational for dealing with the complex issues naturally, socially and physically. 

In objective reality

In micro perspective, as small as atom, extranuclear electrons cloud with the nucleus are both in the state of attraction and repulsion, the electronics rotating around the nucleus in dynamic equilibrium. They are in the state unity of opposites. Atoms are the components to compose of natural substance; also, include human body.

 

      Photo source:https://onlineorganicchemistrytutor.com/atomic-orbital-vs-molecular-orbital/

In macro perspective, the planets with the sun in solar system, and solar system with other galaxies are all in the continuously rotating in the state of self-regulation by attraction and repulsion of each other. They are also in the state of dynamic equilibrium of unity of opposites.  

 

     Photo source: https://www.dreamstime.com/planets-solar-system-model-orbit-milky-way-space-astronomy-galaxy-vector-realistic-illustration-interplanetary-image132784546

In subjective reality

The dialectical thinking is very important when dealing with the social contradiction. In social life, various social contradictions or problems are also the unity of opposites, the two sides of contradiction are the integral part of each other in co-exist or co-perish; the strong and weak position of the contradiction is in the state of dynamic converting. 

TCM is developed by taking the principles and terminology of Daoism, views human body as organic whole of the unity of opposites. In thousand years ago, TCM has recognized that psychological factors are in decisively affecting the development of disease with the belief that disease treatment is seven-tenths in psychotherapy, only three-tenths in medication. A well balanced human body can handle with diseases, so that disease treatment is to restore Yin and Yang balance by natural therapies and medicinals.

Actually; the natural therapies of Acupuncture; Massage; Moxibustion; Cupping are all through improve blood circulation and boost immunity to play their therapeutic role. In the subjective viewing, TCM is to regulate the Yin and Yang balance, but in the objective practice, the process of the regulations is in playing the role of improving the immune function, then the enhanced immune system will naturally clear the pathogenic agent and repair the lesions of diseases.

Modern studies proved correctness of TCM.

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3.2.1... The Physiological Basis of the restoration of Yin and Yang balance

There were many self-recovered cases, especially the people who live a normal life after half brain removed from injury. MRI brain scans show that their existing half brain adaptively re-configured to share some neurons to replace the function of the lost parts. Studies show that our brain is able to continue adaptive re-configuration throughout lifetime, which proved the existence of a physiological basis of the Yin and Yang balance of TCM.

Our brain is always in dynamic functional redistribution with the physical needs in whole lifetime.

Follow is an experiment of the redistribution of functional areas in monkey brain with the changes of external environment from a video Lecture about brain and learning on Youtube.

The speaker is the Prof. Daisy L. Hung, the Ph.D., experimental psychology at the University of California, and a brain scientist. Currently she is the Director and Chair Professor, Institute of Cognitive Neuroscience, College of Science, National Central University, Taiwan.

The monkey's five fingers from the thumb to little thumb numbered as 1- 5, which controlled by the population of brain cells in the regions 1- 5 in the brain respectively.

After the middle finger was removed for three months, the region 3 of the brain that originally controls the middle finger disappeared, and it was divided into the brain regions that control neighboring fingers.

Prof. Daisy L. Hung explained that human brain is staying in the process of dynamic balancing; it only can develop when using frequently. The increase of the brain regions 2 and 4 also shows the increase of the physiological functions of fingers 3 and 4 in taking more daily physical tasks.

A man who lives in a normal life after damaged-half-brain was fully removed.

April 27, 2014, article British tourist who smashed his skull after fall from Thai hotel has titanium plate fitted to fix dent and now hopes to find a 'beautiful wife' reports that a British man live a normal life after left half a head removed from falling down on the 22ft  balcony of a Thai hotel with the left side of his skull smashed; MRI scan found that some areas on right brain have developed as the function of disappeared brain.

A British stroke man who has been 'left to die” by doctors, but himself stood up in 6 months through moving bodies by will, which started from a big toe, then other areas of body.

Dec. 30, 2008, article The heart that grew back: 'Miracle' of girl whose heart healed itself after a third was removed in emergency operation reports that Aged four months Kirsty was born with a rare heart condition, which is frequently fatal within the first three months of life. As a last-ditch attempt to save Kirsty's life, doctor cut away a third of her heart; and later Kirsty's heart grew back and stays in healthy.                

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3.2.2... The Psychological Basis of the restoration of Yin and Yang balance

Jan 8, 2008, article Report: Stress Causes Everything provides the Psychological Basis of the restoration of Yin and Yang balance; I copy as bellow.

窗體底端

Stress, to put it bluntly, is bad for you. It can kill you, in fact. A study reveals that stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer. Thanks to new research crossing the disciplines of psychology, medicine, neuroscience, and genetics, the mechanisms underlying the connection are rapidly becoming understood.

The first clues to the link between stress and health were provided in the 1930s by Hans Selye, the first scientist to apply the word “stress”— then simply an engineering term— to the strains experienced by living organisms in their struggles to adapt and cope with changing environments.

One of Selye’s major discoveries was that the stress hormone cortisol had a long-term effect on the health of rats.

These hormones boost heart rate, increase respiration, and increase the availability of glucose (cellular fuel) in the blood, thereby enabling the famous “fight or flight” reaction.

Because these responses take a lot of energy, cortisol simultaneously tells other costly physical processes — including digestion, reproduction, physical growth, and some aspects of the immune system — to shut or slow down.

When occasions to fight or flee are infrequent and threats pass quickly, the body’s stress thermostat adjusts accordingly: Cortisol levels return to baseline (it takes 40-60 minutes), the intestines resume digesting food, the sex organs kick back into gear, and the immune system resumes fighting infections.

But problems occur when stresses don’t let up —or when, for various reasons, the brain continually perceives stress even if it isn’t really there.

Stress begins with the perception of danger by the brain, and it appears that continued stress can actually bias the brain to perceive more danger by altering brain structures such as those which govern the perception of and response to threat. Prolonged exposure to cortisol inhibits the growth of new neurons, and can cause increased growth of the amygdala, the portion of the brain that controls fear and other emotional responses.

The end result is heightened expectation of and attention to threats in the environment. Stress hormones also inhibit neuron growth in parts of the hippocampus, a brain area essential in forming new memories. In this way, stress results in memory impairments and impairs the brain’s ability to put emotional memories in context.

Think of it this way: Too much stress and you forget not to be stressed out.

In such a way that stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer.

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3.2.3... The Pharmacological basis of the compound medication of TCM

The compound medication is the unique therapeutic method of TCM since thousands years ago; which is putting many different natural medicinals together as one dose to target on different symptoms of diseases at the same time; modern findings proved the correctness.

Oct. 1999; article Phytomedicine Research in Germany reports that, in 1980s Germany made about 300 clinical studies with the phytopharmaceuticals; and found that phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneous advantage of being devoid of any adverse effects; the mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating.

Nov. 2013, article Plant Nutrient 'Cocktail' Kills Breast Cancer Cells reports that “turmeric, soybeans, broccoli, grapes and tea. Individually, they were ineffective against cancer. But combined, they suppressed breast cancer cell growth in the lab by more than 80 percent, and eventually triggered the process leading to cell death.”

Sep. 2019, article Fruit flies live longer with combination drug treatment reports that if it is used individually, lithium, trametinib and rapamycin are able to extend the lifespan of the fruit flies by an average of 11%, but if by any two combined use can increase the lifespan around 30%, and all three combined can reach 48%.

Jan 20, 2021, article Mechanism and material basis of Lianhua Qingwen capsule for improving clinical cure rate of COVID-19: a study based on network pharmacology and molecular docking technology reports that in 13 component drug Lianhua Qingwen capsule; there are total 160 active components produced therapeutic effects against COVID-19; through 57 target proteins, involving 35 signaling pathways and Toll-like receptor signaling pathway. The results of molecular docking showed that 83 chemical components had total scores no less than 5.0 for docking with 12 target proteins with high binding activities to form stable conformations.

Above studies show that the multi-medicinals by compound medication can produce synergistic interaction to increase the therapeutic effect and reduce side effect of each other; which has provided the new drug concept that the best medication will come from the combination of multiple medicinals; the more medicinals combined the more therapeutic effect, the fewer side effects in regardless synthetic drugs or natural medicnals.

3.2.4...Modern study proved the existence of acupuncture meridians

People have been questioning the authenticity of the anatomical basis of acupuncture meridians. Mar.29, 2021, study report In Vivo Visualization of the Pericardium Meridian with Fluorescent Dyes provides evidence of the existence. Fifteen healthy volunteers were enrolled in this study by injecting two fluorescent dyes—fluorescein sodium and indocyanine green —into the dermal layer at acupuncture points and a nonacupoint control. It found slow diffusion of the dye proximally along a path matching closely with the pericardium meridian.

3.2.5... The mechanism of TCM cured Covid-19 patients in less deaths and complications

Lianhua Qingwen capsule is typical compound medication of TCM, its biologically active ingredients, therapeutic mechanism and clinical effects can show the reason that why TCM treats Covid-19 infection without sequelae.

The ingredients of Lianhua Qingwen are all from nature, includes: Forsythia, Honeysuckle, Ephedra, Almond, Gypsum, Iisatis root, Male fern rhizome, Houttuynia cordata, Patchouli, Rhubarb, Rhodiola rosea, Menthol, Licorice. The starch is auxiliary material.

In nature world, a single botanical plant is a compound with multiple physiological ingredients. Lianhua Qingwen is composed of 12 botanicals and 1 mineral. It can be envisaged that the bioactive ingredients are diversified and the number is huge.

Jan. 8, 2015, article Qualitative and Quantitative Analysis of the Major Constituents in Chinese Medical Preparation Lianhua-Qingwen Capsule by UPLC-DAD-QTOF-MS introduced study result that Lianhua Qingwen capsule has total of 61 major constituents. Such a combo is surely can target on large number of targets.

May 16, 2020, article Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial reports that the trial included 284 patients (142 each in treatment and control group) in the full-analysis set. The recovery rate was significantly higher in treatment group as compared with control group. The median time to symptom recovery was markedly shorter in treatment group. Time to recovery of fever, fatigue and coughing was also significantly shorter in treatment group. The rate of improvement in chest computed tomographic manifestations and clinical cure was also higher in treatment group. However, both groups did not differ in the rate of conversion to severe cases or viral assay findings. No serious adverse events were reported.

May 8, 2020, article China Focus: Chinese medicine against COVID-19 gets market entry to Singapore: Traditional Chinese medicines including the Lianhua Qingwen Capsule are effective in the treatment of over 90 percent of all confirmed COVID-19 cases with significantly lowered the proportion of patients whose conditions turn from mild to severe. In vitro experiment proved that Lianhua Qingwen Capsule has a weak inhibitory effect on the virus but has good repair effects on cell damages and inflammation caused by the novel coronavirus.

3.3... Precision seeking Reductionism made Western medicine unsuitable for human life

Reductionism believes that the whole of reality consists of a minimal number of parts. The complex system can be decomposed into simple independent units to understand the whole.

Western medicine develops by taking Reductionism as guidance in viewing human life as the inanimate assembly of lifeless parts by infinitely subdividing body as independent micro unit as genes or proteins to study the development of diseases and by looking for killing and genetic patching as treatment in ignoring that psychological factor in decisively affecting the development of diseases. In 2008, a study of crossing four disciplines reveals that Stress Causes Everything from gums to heart and make susceptible to everything from common cold to cancer.

Until 1955; Western medicine found that placebo effect can achieve 50 – 60% cure rate; and found that many synthetic drugs were ineffective than that of placebo with side effect killing people; then randomized double blind clinic trial often used to prove drug effective than that of placebo did; due to the compositions of natural medicinals of TCM are too complex to meet double blind clinic trial and to be yelled as unscientific and unproven.

Randomized double blind clinic trial dehumanizes people as massive killer

People would never think of that scientific regulation of randomized double blind clinic trial created new crime pattern since it was born; by training people as killers by kicking away the effective medicinals that used in combo by testing in single; the terrible is at its undeniable deceptive to poison people addicted in the state as scientific psychosis to act as global supervisor to yell this medicine was pseudoscience; that one was unscientific; and those were unproven from hearsay.

3.3.1...Some officials and medical experts acted as the killer aider of the Covid-19 virus

It is just that double blind clinic trial misled those top medical experts of consultants of WHO acted as the aider of the Covid-19 virus by kicking away the effective drugs for curing Covid patients; otherwise; there were more than 90% of Covid died people would be still alive and in enjoying life with their beloved families.

In the birthplace of TCM; the Western medicine poisoned people are also rejecting TCM in the treatment of Covid patients; the top leadership of 7 members’ politburo of China have to hold special meeting to force the dehumanized people cooperating with the experts of TCM; so that Covid patients were less death and less long Covid sufferers.

3.3.2... Ban the use of HCQ caused over 50% of global 6.5 million Covid deaths

Since Mar 2020, WHO launched COVID-19 Solidarity Therapeutics Trial that involves 52 countries, 600 hospitals, 2000 researchers and 14,200 hospitalized patients with CONCLUSIONS by report Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results: these Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay.

However, July 2, 2020, article Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients reports that Henry Ford Health System made a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the system’s six hospitals; found that 13% of those treated with hydroxychloroquine alone died compared to 26.4% not treated with hydroxychloroquine. None of the patients had documented serious heart.

3.3.3... Ban the use of Remdesivir caused over 83% of global 6.6 million Covid deaths

April 25, 2022, article Veklury® (Remdesivir) is First and Only Approved Treatment for Pediatric Patients Under 12 Years of Age with COVID-19 reports that the phase 2/3 single arm, open-label study demonstrated that Veklury (Remdesivir) was generally well-tolerated among pediatric patients hospitalized with COVID-19 with a high proportion of participants showing clinical improvement and recovery, as well as data from trials in adults. Of the 53 pediatric patients enrolled in the study, no new safety signals were apparent for patients treated with Veklury. Overall, 60% and 83% were discharged by Day 10 and Day 30, respectively.

3.3.4... Ban the use of Lianhua Qingwen capsule of TCM caused 90% unnecessary death

In the West, by the name of unscientific or unproven banned the use of Lianhua Qingwen Capsule of TCM to have contributed more than 90% of global 6.5 million Covid-19 deaths; according to the achievements of China in fewer Covid deaths; which should attribute to the magic therapeutic effect of compound medication of TCM.

Jan 20, 2021, article Mechanism and material basis of Lianhua Qingwen capsule for improving clinical cure rate of COVID-19: a study based on network pharmacology and molecular docking technology reports that a total 160 active components in 13 component drugs in Lianhua Qingwen capsule produced therapeutic effects against COVID-19 through 57 target proteins, involving 35 signaling pathways and Toll-like receptor signaling pathway. The results of molecular docking showed that 83 chemical components had total scores no less than 5.0 for docking with 12 target proteins with high binding activities to form stable conformations.

May 16, 2020, article Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial reports that “284 patients (142 each in treatment and control group) in the full-analysis set. The recovery rate was significantly higher in treatment by Lianhuaqingwen as compared with control group (91.5% vs. 82.4%, p = 0.022).”

3.3.5... Without proper medications made tragedy of Covid deaths in Britain

Jan. 17, 2021, a report from Britain, Almost a third of recovered Covid patients return to hospital in five months and one in eight die said that out of 47,780 people who were discharged from hospital in the first wave, there 29.4 per cent were readmitted to hospital within 140 days, and 12.3 per cent of the total died. There is a devastating long-term toll on survivors of severe coronavirus, with many people developing heart problems, diabetes and chronic liver and kidney conditions.

Then how did the doctors of Great Britain create such a miracle, a case provides answer.

Feb. 5, 2021, University of Cambridge published report SARS-CoV-2 evolution during treatment of chronic infection to indicate that a 70 years old male was admitted to hospital in positive for SARS-CoV-2. Treatment included two 10-day courses of remdesivir with a 5-day gap in between during the first 57 days. Then two units of convalescent plasma were administered on days 63 and 65. After clinical deterioration, remdesivir and a unit of convalescent plasma were administered on day 95, but the individual died on day 102.

It is really a pity, in the treatment of 102 days; only remdesivir and convalescent plasma were available for the doctors of the Great Britain. However, even if the use of the remdesivir and convalescent plasma were also in against the recommendations of WHO.

Nov. 20, 2020, article WHO has issued a conditional recommendation against the use of remdesivir reports that in hospitalized patients; regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients.

Aug. 24, 2020, article WHO cautious on COVID-19 plasma as U.S. issues emergency authorization reports that WHO chief scientist, said only a few clinical trials of convalescent plasma have produced results, and the evidence, at least so far, has not been convincing enough to endorse it beyond use as an experimental therapy.

It is clear that suppose the doctors of Great Britain followed the recommendations of the WHO; above 70 years old British man would face an embarrassing situation without any treatment available.

People certainly remember that WHO once launched “Solidarity” clinical trial for COVID-19 treatments, in which suggested drugs were all have showed hopeful curative effect in curing covid-19 patients, but all of them were proved as ineffective by double blind clinic trial.

It was just that scientific addiction of the double blind clinic trial misleads people working to kick away the effective medication; by such a way, indirectly; they lengthened torturing of the 70 years old British man to die by lasting 102 days.

People can imagine the feeling of the psychological torture for the doctors of the Great Britain when helplessly viewing own countryman being gradually tortured to die without proper treatment available. 

No matter is from which country; whenever I see videos or photos of medical staff wearing full PPE rescuing patients in ICU, I can't help being tearful. I am happy with their happy when they succeeded in rescuing the patients, and I am tearful with their tear for failed to rescue the patients.

Their efforts are the driving force for me, in driving me to persevere in writing the articles with the hope that can eliminate pandemic covid-19 as soon as possible. Though, sent hundreds of emails and dozens of phone calls, there were no one care about my ideas, but the scenes that medical staff wearing full PPE rescuing patients in ICU are always emerging before my eyes and driven me to continue thinking and typing. 

The tragedy happened in Britain may be the same in Canada, because of the similar treatment under same Reductionism guided Western medicine. Please see the sad report Jan. 28, 2021, The tip of the iceberg COVID long-haulers facing financial ruin and report Jan 28, 2021, Insurance claim denials leave some COVID-19 sufferers planning 'for the worst'.

Globally, there many reports that covid-19 survivors were suffering bad complications in the disabled states. We are not only need to save the life of infected people, but also, we have to ensure the cured people are healthy able to enjoy a quality life; and more importantly, only healthy people can ensure healthy labors to create quality economy for quality life.

3.3.6... French Professor Didier Raoult mistreated by Western medicine dehumanized people

In March and April 2020; French Professor Didier Raoult who happily announced that the hydroxychloroquine combining azithromycin is effective treatment to cure COVID-19 patients; sadly the work did not get appreciation to inspire more people to consider how to use the effective medication to save lives, but it triggered many people into manic state to work hardly for proving the Professor Didier Raoult is a liar; even sued; which has far beyond the issue in medicine.

Here were Googled disappointed reports in May 12, 2020, He Was a Science Star. Then He Promoted a Questionable Cure for Covid-19 and Sep. 17, 2021, French scientist who promoted one of Trump’s favorite coronavirus cures set to be replaced.

May 27, 2021, Scientists rally around misconduct consultant facing legal threat after challenging COVID-19 drug researcher.

May 11, 2021, Controversial French doctor Raoult in disciplinary hearing over notorious Covid-19 tips.

Now the fact has proved that Professor Didier Raoult was correct in the treatment of covid-19 patients by the use of hydroxychloroquine combining azithromycin.

Now, here, I infer that if professor integrates more medicinals to combine with hydroxychloroquine besides the use of an azithromycin; he would find god medicine with stronger therapeutic effect to reduce the Covid deaths in more than 90%.

In the earlier time of the start of pandemic Covid-19; the personal attack on Professor Didier Raoult for the use of hydroxychloroquine combining azithromycin have certainly caused many deaths of French people and the people globally. Obviously; those people who attacked Professor Didier Raoult have committed crime of helping virus killed millions of people.

No matter how their reason was sound and reasonable; but it caused massive deaths were there.

The fact has clearly showed that, as same as that of the European bloody looting and killing Dark Ages bred Western Individualistic Civilization; it derived Western medicine also has magic to dehumanize some of people into psychotic state; though they are only in a very small minority; but such people are without ability for reasoning the bad consequence; so that they are over active socially and seizing the leading social position to recklessly make trouble to others and society.

It is unbelievable that, even if in the birthplace China, TCM has long been attacked as unscientific or even as witch witchcraft by the experts who were trained by Western medicine. For treating covid-19 patients; those experts also reject the participation of the experts in TCM; so that China’s top leadership of seven members’ politburo has to hold special meeting to force the experts in Western medicine cooperating with the experts in TCM, then; under the enforcement of government; the synthetic drugs and natural medicinals were combining used to have cured patients quickly with lesser deaths and complications.

People may ask that why so many people take wrong as right and promote bad for good in stubborn insisting unchangeable; without sense for reasoning the bad consequence that will badly harm the life of people; and themselves and their families; which relates to the limitation of human intelligence that is decided by the quality of brain and the acquired knowledge.

3.3.7... It is the globally distributed medical experts in misleading WHO wrongful directing

Add this topic here want to show the terrible reality that the most of Western medicine trained medical experts are in the psychotic state without proper reasoning ability for qualifying their duties in stubbornly taking stupid as smart; taking wrong as right and promoting bad for good. Due to ignorance; they are the actually killer for the most of disease death.

Since the outbreak of the pandemic Covid19, the officials of WHO have been emaciated very much; which shows that they have endured too much psychological torment and which proved their higher personal quality; however, viewing back today, the officials of WHO seem played a extreme bad negative role by endorsing false medical research results to amplify their harm by increasing the deceptiveness with the trustable name of world's highest health authority - WHO.

April 6, 2022, Nature News published article Why the WHO took two years to say COVID is airborne to have revealed the process of WHO making anti-pandemic guidance, it is globally distributed experts of Western medicine in providing suggestions to WHO for directing global anti-pandemic practice, but the officials of WHO seem adopted the wrong one. I excerpt some of the article as bellow.

Early in the pandemic, the World Health Organization stated that SARS-CoV-2 was not transmitted through the air. That mistake and the prolonged process of correcting it sowed confusion and raises questions about what will happen in the next pandemic. In early 2020, public-health advice on COVID-19 focused on sanitizing surfaces more than protecting against airborne transmission.

As 2021 drew to a close, the highly contagious Omicron variant of the pandemic virus was racing around the globe, forcing governments to take drastic actions once again. The Netherlands ordered most businesses to close on 19 December, Ireland set curfews and many countries imposed travel bans in the hope of taming the tsunami of COVID-19 cases filling hospitals.

Amid the wave of desperate news around the year-end holidays, one group of researchers hailed a development that had seemed as though it might never arrive. On 23 December, the World Health Organization (WHO) uttered the one word it had previously seemed incapable of applying to the virus SARS-CoV-2: ‘airborne’. On its website, a page titled ‘Coronavirus disease (COVID-19): How is it transmitted?’ was quietly edited to state that a person can be infected “when infectious particles that pass through the air are inhaled at short range”.

The change brings the WHO’s messaging in line with what a chorus of aerosol and public-health experts have been trying to get it to say since the earliest days of the outbreak. Many decry the agency’s slowness in stating — unambiguously — that SARS-CoV-2 is airborne.

Interviews conducted by Nature with dozens of specialists on disease transmission suggest that the WHO’s reluctance to accept and communicate evidence for airborne transmission was based on a series of problematic assumptions about how respiratory viruses spread. For example, even in the middle of the fast-moving epidemic, the WHO dismissed field epidemiology reports as proof of airborne transmission because the evidence was not definitive, something that is difficult to achieve quickly during an outbreak.

Other criticisms are that the WHO relies on a narrow band of experts, many of whom haven’t studied airborne transmission, and that it eschews a precautionary approach that could have protected countless people in the early stages of the pandemic.

Critics say that inaction at the agency led to national and local health agencies around the world being similarly sluggish in addressing the airborne threat. Having shifted its position incrementally over the past two years, the WHO also failed to adequately communicate its changing position, they say. As a result, it didn’t emphasize early enough and clearly enough the importance of ventilation and indoor masking, key measures that can prevent airborne spread of the virus.

Mounting evidence suggests coronavirus is airborne — but health advice has not caught up.

But Dale Fisher, an infectious-diseases physician at the National University Hospital in Singapore and chair of the WHO’s Global Outbreak Alert and Response Network steering committee, doesn’t think that confusion over whether the virus is airborne has had a defining impact on how the pandemic has played out. “It’s not the cause of the catastrophe we’ve seen,” he says.

Some other researchers defend the agency’s response, given the rapidly evolving situation. “I really don’t think anybody dropped the ball, including WHO,” says Mitchell Schwaber, an infectious-diseases physician at Israel’s ministry of health and an external adviser to the WHO. “So many assumptions that we had about this virus were proven false. We always, we always were learning new things.”

Lidia Morawska, an aerosol scientist at the Queensland University of Technology in Brisbane, Australia, spearheaded several efforts to convince the WHO and other health agencies of the airborne threat. She says that airborne transmission was “so obvious” as far back as February 2020, and that omitting it from official guidelines was disastrous.

In the final days of March 2020, Morawska contacted dozens of colleagues — an international mix of aerosol scientists, infectious-disease specialists, and building and ventilation engineers — to get the word out about the airborne threat of SARS-CoV-2. On 1 April 2020, the group sent an e-mail laying out their case to Michael Ryan, head of the WHO’s Health Emergencies Programme, and Maria Van Kerkhove, technical lead of the WHO’s COVID-19 response.

Within an hour, the agency was on the phone. Two days later, the group attended a video conference with members of the Health Emergencies Programme and the Infection Prevention and Control Guidance Development Group (IPC GDG) — an external group of about 40 clinicians and researchers that advises the WHO on infection containment, especially in hospitals. At the time of the meeting, more than one million people had been infected with SARS-CoV-2, and 54,000 had died. Community spread was rampant in several countries.

Morawska presented what she says was a compelling case for airborne transmission. Two facts stood out. First, there was solid evidence that people were becoming infected even when they were more than one metre — the safe distance recommended by the WHO — from a contagious individual. Second, years of mechanistic studies had demonstrated how mucus in a person’s airway can spray into aerosols during speech and accumulate in stagnant rooms. Morawska felt rebuffed by the WHO and its advisers. “I didn’t have a feeling that they were trying to see this from our perspective,” she says.

She and other people who study aerosols and airborne disease transmission say that the IPC GDG is ill-equipped to assess this type of transmission because most of its members have focused on controlling infections in hospitals and they lack expertise in the physics of how airborne contagions spread. At the time of the 1 April meeting, no one in the IPC GDG had studied this type of disease transmission, say critics.

July 6, 2020, Professor Lidia Morawska and 239 scientists from 32 countries jointly published article It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19), but also it was helpless.

Early WHO advice on masks recommended them only for infected people and their carers. “What the WHO says is normally based on a consensus of expert advice and opinion,” says Christopher Dye, an epidemiologist who served as the scientific adviser to the agency’s director-general until 2018.

3.3.8... The genetic studies and the products can never be benefit; but harm human life

In 2003, we once cheered for the completion of Human Genome Project with the happy that we could uproot all diseases as easy as that of adjusting the clock time by turning the hands of the clock. Since then, the medical spending was mostly wasted in the studies of genetic therapies and such stuff reported endlessly; but, until today, there no one is stable applied clinically. Because of, human body is complex organic system; there are dozens even hundreds different gene-fragments in affecting one disease; and under the decisive affecting of the uncontrollable psychological factors.

I infer that the genetic studies and the products can never be benefit; but harm human life by fatal side effect and even used to develop biological weapons as that of Covid-19 by easily messing harmony organic system of human life.

3.4... Rationalize medical philosophy to optimize disease treatment and medication

The way out is at rationalizing medical philosophy by philosophy Reductionism of Western medicine integrating the philosophy Daoism of TCM to enjoy complementary advantages of each others; then from viewing human life as lifeless assembly to view human life as emotional organic whole; then the concept of disease treatment will be rationalized from looking for killing and genetic patching to make restoration of Yin and Yang balance; and the concept of drugs will be rationalized from looking for developing synthetic one with side effect to look for optimal combination of existing medicinals in regardless of the synthetic drugs or natural medicinals; then it will trigger brand new drug concept; which is that any substance that is able to provide multi-therapeutic effect will be god medicine.

Based on integrated medical philosophy; we may explore safe, effective and cheaper medicinals that are able to make breakthrough in disease treatment and help people self-help in disease treatment and prevention; thereby reducing the reliance on public healthcare; by which solve the dilemma of healthcare of that drugs are expensive unaffordable; while more and more patients overwhelming hospitals.

3.4.1... Drug concept revolution: The electronegativities of atoms in polar chemicals can be used for therapy

This point is extremely important, and I must point out at first.

The thousands of years use as condiment and medicine; vinegar has been proven safe for internal use. And modern studies reveal that the therapeutic effects of vinegar almost cover all of the diseases. The LD50 of sodium hypochlorite is 330g/50kgLD50 in double safer than that of vinegar in 165g/50kg.

As my long experience for curing flu of fever and cough, oral 1g vinegar/50kg in once can achieve immediate effect; which is far-far to the amount of 165g/50kg of LD50. According to LD50, I infer that the therapeutic effect of Hypochlorous acid will be much stronger and safer than that of vinegar.

Suppose that we inhale Hypochlorous acid produced inhalable antiviral air in daily once, it will be not only able to prevent any type of virus caused airborne infectious diseases; but also it will be able to cure diseases as that of vinegar did; while promoting health keeping to reduce the occurrence of diseases.

                                    <<<<<<>>>>>>

For many years, I drink water diluted 20ml 5%vinegar / 50kg as treatment and healthcare. It is able to immediately cure flu of fever, cough and runny nose; cure periodontitis and restore receded-gums in days; while inhale vinegar mixed air is able to eliminate sticky sputum in throat, and thereby reducing snoring and apnea when sleeping of the inducement for many fatal diseases; also the long indigestion of stomach problems and irritable bowel syndrome were cured.

I specially searched the medicinal use of vinegar and shocked by the therapeutic effects that almost cover all of the diseases, except not studied; so it said that vinegar is cure for all. Lab studies proved that drinking water diluted vinegar can increase the immune cells in the blood of mice and decrease the fat of abdominal and intestinal wall of chicks. Also it benefits to Arthritis, Hypertension, Diabetes, and so on. Please Google; you will be surprised by the results that vinegar is a typical God Medicine.

It is clear, that amazing therapeutic effects of vinegar cannot be achieved by existing synthetic drugs or natural medicinals; and also it cannot achieve by the ingredients that brought from raw materials or the derivatives from fermentation of vinegar as commonly argued, but I infer that it is derived from the electronegativities of polar bond of oxygen atoms in vinegar molecular.

The electronegativity is a measure of an atom's ability to attract shared electrons to itself; so that the chemical effect of electronegativities of Oxygen atoms in vinegar molecular is able to kill viruses and bacteria by impacting their covalent bonded structure; while the electronegativity is able to stimulate the physiological activities of covalent bond structured human tissue and organs to produce full cover therapeutic effects without formation of drug resistance.

Also; this is why that vinegar can be home used to clean the grease stains.

Then according to above inference, we may find and develop more and powerful medicinal compounds to serve human being in disease treatment. 

According to article Interactive Periodic Table of Elements, the concept of electronegativity is basically figure of the tendency of a given chemical’s atom to attract the pair of electrons. This attraction tendency of an atom is affected by its electronegativity numbers. The more is the value of electronegativity for a given chemical element the stronger would be its attraction of electrons. See Interactive Periodic Table of Elements below.

      Photo Source: https://periodictable.me/electronegativity-series-in-increasing-order/ 

According to the value of electro-negativity from large to small, the order of the atoms should be F (4.0) > O (3.5) > Cl (3.0) = N (3.0) > Br (2.8) > C (2.5) = I (2.5) = S (2.5).

Above order of the atoms provide an inspiration for finding or developing more powerful compound for medicinal use.

I am sure that many existing chemical compounds have magic therapeutic effects than that of vinegar doing, but the wrongful adopted philosophy Reductionism misguided Western medicine cultured people ignore that. The terrible is that, by the pretext of unsafe, some people reject the use of those chemical compounds that have proved magic therapeutic effect.

Many of Western medicine cultured people have no rational sense that any drugs have LD50 as warning for use in safe. Any medicinals need to explore the optimal dosage in safe and effective.    

3.4.1.1... Vinegar keeps me a healthy teeth and away from snoring and apnea

Jan. 26, 2020, in article Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for 2019 new coronavirus and other acute and chronic diseases, I introduced my friendly associates with vinegar.

Since about my 30, my teeth has been in the state of uncertainty of sore when eating or drinking of cold, hot, or sour. Tried with various medicinal toothpastes to brush them, but still doesn't work well.

In 2017, the two lower teeth in the middle are loose, and they have been in the state of trying to split up with me. When eating, I had to be very careful.

One day, I thought that since vinegar can kill bacteria, why not try to gargle my teeth with vinegar, the effect is very good. Later, I bought a small toothbrush, after eating something; I cleaned the teeth with the toothbrush dipped in 0.05% vinegar and then gargle my mouth with 0.05% vinegar, and then rinsed my mouth with water to wash the vinegar away. Otherwise, the teeth feel bad.

                                                        The small toothbrush

The picture below shows the lower teeth of right now, which just taken with a mobile phone when I writing to here. The gums have grown and are firm. The roots are not dark anymore. I was no longer worrying about them splitting with me since the start of gargling my teeth with vinegar.

                                      

Since cleaning my teeth with vinegar, the cold, hot, and sour are all powerless to my teeth, and I have been enjoying the most comfortable teeth since my 30.

Vinegar can avoid snoring and apnea

Jan. 26, 2020, in article Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for 2019 new coronavirus and other acute and chronic diseases, I indicate that “According to my personal experience, vinegar can immediately stop a runny nose, stop cough by eliminating swelling and itching of the respiratory tract, eliminate sticky sputum that can't be coughed out in the throat, and thereby reducing snoring and apnea.”

“Autopsy showed that a large amount of mucus blocked the bronchial airway inside the lungs, and then asphyxia caused the death of patients with new coronary pneumonia. Vinegar can eliminate snot and sticky sputum; it certainly can reduce the mucus from the bronchial airway inside the lungs.”

I feel that snoring and apnea are caused by the sticky sputum in throat, which cannot be coughed up, and stuck small tongue, so that makes it unable to close and open freely. It is said that vinegar contains potassium that can dilute phlegm. Thus, vinegar can reduce snoring and apnea.

I have been using vinegar for avoiding snoring and apnea by putting it in a plastic bag and opening the bag to inhale the volatile. The method will be an easy way for the use of antiviral volatile in the process of pandemic prevention; with the advantage of convenient carrying in pocket for daily use. According to my personal experience, vinegar can immediately stop cough and runny nose.

Vinegar is able to eliminate periodontitis

The periodontitis is the cause of many diseases; my experience show that vinegar is able to eliminate the dental stone; and thus avoid the happen of periodontitis.

Vinegar is able to cure and prevent Osteoporosis

Feb. 21, 2016, Metabolite Profiling Reveals the Effect of Dietary Rubus coreanus Vinegar on Ovariectomy-Induced Osteoporosis in a Rat Model:

The study was aimed at exploring the curative effects of Rubus coreanus (RC) vinegar against postmenopausal osteoporosis by using ovariectomized rats as a model. The investigations were performed in five groups: sham, ovariectomized (OVX) rats without treatment, low-dose RC vinegar (LRV)-treated OVX rats, high-dose RC vinegar (HRV)-treated OVX rats and alendronate (ALEN)-treated OVX rats. The efficacy of RC vinegar was evaluated using physical, biochemical, histological and metabolomic parameters. Compared to the OVX rats, the LRV and HRV groups showed positive effects on the aforementioned parameters, indicating estrogen regulation. Plasma metabolome analysis of the groups using gas chromatography-time of flight mass spectrometry (GC-TOF-MS) and ultra-performance liquid chromatography quadrupole-TOF-MS (UPLC-Q-TOF-MS) with multivariate analysis revealed 19 and 16 metabolites, respectively. Notably, the levels of butyric acid, phenylalanine, glucose, tryptophan and some lysophosphatidylcholines were marginally increased in RC vinegar-treated groups compared to OVX. However, the pattern of metabolite levels in RC vinegar-treated groups was found similar to ALEN, but differed significantly from that in sham group.

The results highlight the prophylactic and curative potential of dietary vinegar against postmenopausal osteoporosis. RC vinegar could be an effective natural alternative for the prevention of postmenopausal osteoporosis.

Jan 26, 2016, Enhancing effect of dietary vinegar on the intestinal absorption of calcium in ovariectomized rats:

We studied the effect of dietary vinegar on calcium absorption by using ovariectomized rats fed on a low-calcium diet. The apparent absorption of calcium was higher when the rats were fed on a diet containing 1.6% vinegar for 32 days than when fed on a diet without vinegar (P < 0.05). The calcium content in the femur of the rats given diets containing 0.4% and 1.6% vinegar were also higher (P < 0.05). The serum parathyroid hormone level was lower and the crypt depth of the duodenum thicker in the rats fed on a diet containing 1.6% vinegar (P < 0.05). These results suggest that dietary vinegar enhanced intestinal calcium absorption by improving calcium solubility and by the trophic effect of the acetic acid contained in vinegar, which would reduce the bone turnover caused by ovariectomy and be helpful in preventing osteoporosis.

3.4.1.2... Corrosive injury of vinegar is able to self-heal without complications

On Hong Kong Med J. 2002 Oct;8(5):365-6, there was a report Corrosive oesophageal injury following vinegar ingestion.

“A 39-year-old woman experienced a foreign body sensation and pain in the left side of her throat after eating crab at dinner. She suspected a small piece of crab shell might be lodged in her throat. She drank one tablespoon of household rice vinegar (usually used for cooking) in the belief that it would dissolve the shell, the sensation of foreign body and pain persisted.”

“The patient attended a general out-patient clinic the next day and was referred to the accident and emergency department. She enjoyed good health with no history of heartburn, regurgitation, dysphagia, odynophagia, epigastric distress, or gastrointestinal bleeding. There was no retching or vomiting before or after the foreign body sensation. Neither had she probed her throat or tried to induce vomiting. Vital signs were normal. She did not have a fever. Examination revealed scattered whitish patches on the posterior pharyngeal wall. No foreign body was identified.”

“Lateral X-ray of the neck did not reveal any abnormality. She was discharged with an endoscopy appointment for the next morning. The endoscopic finding was inflammation of the oropharynx and second-degree caustic injury of the oesophagus from 22 to 30 cm (Fig 1) and the cardia (Fig 2). There was no evidence of a foreign body. The rest of the stomach and duodenum were normal.”

                Fig 1 and Fig 2.

“She was discharged with antacids. Since she was entirely symptom-free at the follow-up visit 1 week later, endoscopy was not repeated. At another follow-up visit 4 months later, she remained symptom-free.”

She had an uneventful recovery.

Now, there are reports that vinegar can erode teeth, so use it with caution. My personal experience proved that this statement is not reliable. Maybe vinegar will really erode our teeth, but as long as we don't brush teeth after using vinegar, it won't cause harm.

More importantly, vinegar can remove the calculus, and then the self-growth of the teeth will offset the corrosion. According to the dentist, for cleaning up the calculus, it needs to be divided into several times, the gum has to cut for open, and the roots of teeth are polished with a brush; thus once a year, it is in paying good money for bad suffering.

The fact was clear that vinegar is intelligent and friendly to humans and can help to solve many thorny problems. It kills pathogens from the physiological structure and does not harm our body, but with great many benefits to humans if you Google right now.

Though the use of vinegar is safe, but when used by intravenous infusion requires a suitably low concentration to avoid swelling of the inner wall of the blood vessel.

I drunk 20ml 5% vinegar after diluted by 500ml water, it is 0.002% vinegar, but I still feel the irritation of vinegar, if I don’t gargle mouth by water, I would feel uncomfortable in my throat.

So, it needs to take special caution when using it by intravenous infusion.

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3.4.1.3... Vinegar has wide range of physiological and pharmacological functions

The LD50 (the dose that will kill 50% of a population of the test subjects) of vinegar is 3,320 mg/kg, it will be 165g for a people of 50 kilo. 5 ml 5% vinegar will be about 0.25 g in pure vinegar. It is far from dead dose of 165 g.

Vinegar has been medicinal used since ancient times in both China and the West. The grain vinegars or fruit vinegars are medicinal combo that can be used as medications for the prevention and treatment of Covid-19.

In ancient China, the vinegar used to treat diseases in wide range: anti-vomit; anti-diarrheal; reduce swelling; nourish liver; strengthen muscles; sober mind; remove blood stasis; stop bleeding; detoxification; nourish lungs; promote digestion; increase appetite; kill roundworms; reduce anxiety; prevent dizziness; treat sores and stop yellow sweat; treat jaundice; treat genital itching, treat postpartum hemorrhage; etc.

Therefore, vinegar will be an effective agent for antiviral volatile as the medication for the prevention and treatment on Covid-19 infections.

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Google found that vinegar has therapeutic effects that are able to cover the most of diseases; which is in acting as same as that of multi-targeted medicinal combo with multi-therapeutic effects. Some people attribute the pathogenic killing effect and the therapeutic effect of vinegar to the ingredients from raw materials and the derivatives that produced during the vinegar fermentation process.

But, as my judgment, the main pathogenic killing effect should attribute to vinegar’s two oxygen atoms with electronegativities that can attract electrons from other atoms, which can easily kill any virus and bacteria by destroying their covalent bonded structure as that of taking off the parts of viruses and pathogens.

                             

The multi-therapeutic effects of vinegar should also attribute to the electronegativities of oxygen atoms. Here, I cannot make clear the therapeutic mechanism; but I would like to infer that the electronegativities of oxygen atoms possess ability to promote physiological activity of covalent bond structured human body. This action may cause harm to human body, but human body can intelligently transform the harm into beneficial.

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3.4.1.3.1... Fumigation of vinegar steam will be able to cure Covid-19 patients and the survivors’ complications

I infer that vinegar fumigation will be better than using a ventilator for treating critical Covid-19 patients; the ventilator can only help the patient to breathe without other therapeutic effects. But vinegar can eliminate the swelling, itching and sputum in the respiratory tract; thereby effectively reduce the symptoms of coughing and dyspnea and thereby improve patient's ability for breathing independently.

Also, by the exchanges between the alveoli and pulmonary capillaries blood, the vinegar fumigation can reach the effect of systemic administration. Thus, at the time kills pathogens, the multi-targeted therapeutic effects of vinegar will be able to cure the multi-lesions of patients and improve the physical functions in an all-round way. This unique effect of vinegar cannot be achieved by any other medicinals.

Here, I also infer that vinegar fumigation will be effective on the most of diseases without side effect.

There two unique functions of vinegar may attract people to willingly breathe its volatile every day.

1... Vinegar can significantly decreased abdominal fat.

2... Inhaling vinegar volatile can stop snoring and apnea.

Ladies will willing use it for maintaining a fit body shape, men will willing use it for avoiding snoring and apnea; as the byproducts, which will produce the effect of preventing the airborne infectious diseases.

Honey, Melatonin and natural Chinese medicinals are all possessing multi-curative effects that cover the most of diseases in acting as same as that of multi-targeted medicinal combo.

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3.4.1.3.2... Studies proved that vinegar can effectively inactivate SARSCoV-2

Jun. 24, 2020, Japan, study report Virucidal effect of acetic acid and vinegar on SARSCoV-2: Both 4% and 6% acetic acid aqueous solutions effectively inactivated the virus after 5-min incubation with a reduction over 4 log, resulting in a viral titre below the detection limit. In addition, white distilled vinegar (5% and 6% acetic acid concentrations) inactivated SARS-CoV-2 after 1-min incubation with reduction of over 4 log and a viral titre below the detection limit.

July 20, 2020, Italy, study report Vinegar and Its Active Component Acetic Acid Inhibit SARS-CoV-2 Infection In Vitro and Ex Vivo: both vinegar and acetic acid strongly inactivate SARS-CoV-2 infectivity in Vero cells. The vinegar treatment caused a 90% inhibition of the infectious titer when directly applied to a nasopharyngeal swab transfer medium of a COVID-19 patient. The fumigation of vinegar at low concentration (0.34%) ameliorated the symptoms of mild SARS-CoV-2 infection.

Above research reports are very promising. If we only consider to eliminate the function of virus replication rather than kill them, then, maybe a lower vinegar concentration can be achieved. Thus, vinegar will be safe and effective agent for inhalable antiviral volatile to kill possible virus in respiratory tract by inhaling several breaths daily once.

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Vinegar reduces the risk of Covid-19 death from relieving major comorbidities

February 9, 2021, article Comorbidities in SARS-CoV-2 Patients: a Systematic Review and Meta-Analysis indicates that cancer, chronic kidney diseases, diabetes mellitus, and hypertension were independently associated with mortality in COVID-19 patients. Chronic kidney disease was statistically the most prominent comorbidity leading to death.

3.4.1.3.3... Vinegar cures cancer

Apr. 3, 2018, article Acetic acid is an oxidative stressor in gastric cancer cells reports that cancer cell-selective death was induced at the concentration of 2–5 μM acetic acid. Cancerous gastric mucosal cells had increased expression of monocarboxylic transporter 1 and high uptake of acetic acid, compared to normal gastric mucosal cells. The exposure of cancerous gastric mucosal cells to acetic acid enhanced production of reactive oxygen species and expression of monocarboxylic transporter, and induced apoptosis. The acetic acid induced cancer cell-selective death in gastric cells through a mechanism involving oxidative stress.

Dec. 16, 2008, article Induction of apoptosis in human leukemia cells by naturally fermented sugar cane vinegar (kibizu) of Amami Ohshima Island reports that the apoptosis was induced in the leukemia cell by the fraction of sugar cane vinegar and resulted in the repression of growth of the human leukemia cells. Chromatographic fraction of sugar cane juice eluted by 20% methanol showed potent activities of radical-scavenging and growth repression of HL-60. These results led us the consideration that active components in sugar cane juice could be converted to more lipophilic compounds with activity to induce apoptosis in HL-60 by microbial fermentation with yeast and acetic acid bacteria.

Jul. 26, 2019, article Apoptosis and metastasis inhibitory potential of pineapple vinegar against mouse mammary gland cells in vitro and in vivo reports that, in vitro study, an IC50 value of 0.25 mg/mL after 48 h of treatment was established. Annexin V/PI and scratch closure assays showed that pineapple vinegar induced 70% of cell population to undergo apoptosis and inhibited 30% of wound closure of 4 T1 cells. High concentration of pineapple vinegar (2 ml/kg body weight) led to the reduction of tumor weight and volume by 45%as compared to the untreated 4 T1-challenged mice. This effect might have been contributed by the increase of T cell and NK cells population associated with the overexpression of IL-2 andIFN-γ cytokines and splenocyte cytotoxicity. Furthermore, fewer instances of metastasis events were recorded in the pineapple vinegar treatment group and this could be explained by the downregulation of inflammation related genes.

The ability of pineapple vinegar to delay cancer progression portrayed its potential as chemopreventive dietry intervention for cancer therapy.

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3.4.1.3.4... Dietary vinegar can enhances the intestinal absorption of calcium

Google; it will show a lot articles in talking about vinegar will dissolve calcium and minerals in bones and leading to osteoporosis. However, labs study show that dietary vinegar can enhances the intestinal absorption of calcium to prevent osteoporosis; which shows that it has much room for the further study on the long term effect of Vinegar and Melatonin, especially the effect of vinegar in calcium absorption, whether it dissolve calcium to cause osteoporosis.

May 1999, study report Enhancing effect of dietary vinegar on the intestinal absorption of calcium in ovariectomized rats.

Abstract

We studied the effect of dietary vinegar on calcium absorption by using ovariectomized rats fed on a low-calcium diet. The apparent absorption of calcium was higher when the rats were fed on a diet containing 1.6% vinegar for 32 days than when fed on a diet without vinegar (P < 0.05). The calcium content in the femur of the rats given diets containing 0.4% and 1.6% vinegar were also higher (P < 0.05). The serum parathyroid hormone level was lower and the crypt depth of the duodenum thicker in the rats fed on a diet containing 1.6% vinegar (P < 0.05). These results suggest that dietary vinegar enhanced intestinal calcium absorption by improving calcium solubility and by the trophic effect of the acetic acid contained in vinegar, which would reduce the bone turnover caused by ovariectomy and be helpful in preventing osteoporosis.

2016 Jan 26, 2016, study report Metabolite Profiling Reveals the Effect of Dietary Rubus coreanus Vinegar on Ovariectomy-Induced Osteoporosis in a Rat Model.

Conclusions

Our study evaluated the effect of RC vinegar on ovariectomy-induced osteoporosis in rats by employing biochemical and metabolomic methods, including GC-TOF-MS and UPLC-Q-TOF-MS. Our results demonstrated that RC vinegar has a positive effect on bone mass, bone resorption and bone strength in experimental rat groups under controlled conditions. We further established that oral administration of RC vinegar decreased the BMD loss, which was accompanied by the reduction in serum ALP and OC levels and a consequent bone volume increase in treated rats (HRV and LRV) compared to OVX.

The study provides valuable insight into the RC vinegar-mediated reduction in bone loss and bone turnover rates in ovariectomized rats, mimicking the human postmenopausal conditions.

Additionally, eight potential metabolites, including butyric acid, phenylalanine, glucose, tryptophan and lysoPC 16:0, lysoPC 18:0, lysoPC 20:4, and lysoPC 22:6, were identified as osteoporosis hallmarks in ovariectomized rat groups. Moreover, the study further highlights the precedence of MS-based analytical and multivariate (PLS-DA) data interpretation methods towards the precise and rapid interpretation of colossal metabolomics data. The present methodology can further be anticipated to address the dietary or health food correlations with an organisms’ “-omics” and health phenotypes.

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3.4.1.3.5... Vinegar cures chronic kidney diseases

Mar. 1, 2020, article Alteration of the gut microbiota by vinegar is associated with amelioration of hyperoxaluria-induced kidney injury reports that Using an ethylene glycol (EG)-induced hyperoxaluria rat model, we evaluated the effects of the vinegar on renal injury. Oral administration of vinegar (2 ml kg-1 day-1) reduced the elevated serum creatinine, BUN, and protected against hyperoxaluria-induced renal injury, renal fibrosis, and inflammation.

Gut microbiota analysis of 16S rRNA gene showed that vinegar treatment altered their microbial composition, especially the recovery of the levels of the Prevotella, Ruminiclostridium, Alistipes and Paenalcaligenes genus, which were significantly increased in the hyperoxaluria-induced renal injury rats. Additionally, liquid chromatography-mass spectrometry (LC-MS)-based metabolome analysis showed that total of 35 serum and 42 urine metabolites were identified to be associated with protective effects of vinegar on hyperoxaluria-induced renal injury rats. Most of these metabolites were involved in thiamine metabolism, glycerol phosphate shuttle, biotin metabolism, phosphatidylcholine biosynthesis and membrane lipid metabolism.

Importantly, the effects of vinegar against renal injury were weakened after depletion of gut microbiota by antibiotic treatment. These results suggest that vinegar treatment ameliorates the hyperoxaluria-induced renal injury by improving the gut microbiota and metabolomic profiles.

Sep. 30, 2020, article Protective role of apple cider vinegar (APCV) in CCl4-induced renal damage in wistar rats reports reports that compared to the control animals, CCl4 administration caused kidney damage as evidenced by significant (P < 0.05) increase in the evaluated indices (urea, creatinine, Na+ and K+). Interestingly, treatment of CCl4-exposed rats with APCV markedly reversed the above alterations to near normal. Besides, APCV treatment ameliorated the histological derangements (hemorrhagic lesions) caused by CCl4 in the kidney of the experimental rats.

These observations apparently suggest that Apple cider vinegar has the therapeutic potential to protect against renal impairment and attendant malfunction.

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3.4.1.3.6... Vinegar cures diabetes mellitus

May 6, 2015, article Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes reports that 11 subjects with DM2 consumed vinegar or placebo. Vinegar compared to placebo (1) increased forearm glucose uptake (p = 0.0357), (2) decreased plasma glucose (p = 0.0279), insulin (p = 0.0457), and triglycerides (p = 0.0439), and (3) did not change NEFA and glycerol. Conclusions. In DM2 vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar's effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle.

3.4.1.3.7... Vinegar reduces hypertension

22 May 2014, article Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats reports that the acetic acid itself, the main component of vinegar, significantly reduced both blood pressure (p<0.05) and renin activity (p<0.01) compared to controls given no acetic acid or vinegar, as well as vinegar. There were no significant differences in angiotensin I-converting enzyme activity in various organs. As for the mechanism of this function, it was suggested that this reduction in blood pressure may be caused by the significant reduction in renin activity and the subsequent decrease in angiotensin II. From this study, it was also suggested that the antihypertensive effect of vinegar is mainly due to the acetic acid in it.

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3.4.1.3.8... Vinegar raised hemoglobin, total erythrocyte counts and total leukocyte counts

April 11, 2001, research report The effect of cider vinegar on some nutritional and physiological parameters in mice said that the hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all vinegar treated groups.

3.4.1.3.9... Vinegar destroys cell walls, protein structure, and nuclear proteins of the pathogenic organisms

Jan. 29, 2018, research report Apple cider vinegar can help clear bacteria and yeast infections; a natural cure said that vinegar could potentially protect the body from harmful bacteria by stopping the growth of bad bacteria and fungus in its tracks, stopping the spread of these infections by destroying their cell walls, protein structure, nuclear proteins, metabolic enzymes altering their structure of the pathogenic organisms.

3.4.1.3.10... The anti-Inflammatory effect of vinegar may reduce the risk of Cardiovascular Disease

Journal of the American College of Cardiology, Volume 76, Issue 19, 10 November 2020 published report that Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S..

A study of 5,291,518 person-years of follow-up, 15,837 incident CVD cases, 9,794 coronary heart disease (CHD) cases and 6,174 strokes to have gotten the conclusions that dietary patterns with a higher proinflammatory potential were associated with higher CVD risk. Reducing the inflammatory potential of the diet may potentially provide an effective strategy for CVD prevention.

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3.4.1.3.11... 1 - 3% vinegar can inactivate avian influenza virus

June 2009, study report Inactivation of avian influenza virus using four common chemicals and one detergent: “Five disinfectant chemicals were tested individually for effectiveness against low pathogenic avian influenza virus (LPAIV), A/H7N2/Chick/MinhMa/04, on hard, nonporous surfaces. The tested agents included acetic acid, calcium hydroxide, sodium carbonate, sodium hydroxide, and a powdered laundry detergent without bleach. Multiple common chemicals including acetic acid (1 and 3%), sodium hydroxide (2%), and calcium hydroxide (1%) effectively inactivated LPAIV on a metal surface.

3.4.1.3.12... 4 - 8% vinegar can inactivate H1N1 human influenza virus

Feb. 1, 2010, Effectiveness of Common Household Cleaning Agents in Reducing the Viability of Human Influenza A/H1N1: A British Standard was adapted to assess the ability of various household cleaning agents to kill or reduce the infectivity of an H1N1 human influenza virus A/PuertoRico/8/34 (PR8, H1N1, Cambridge lineage). A low concentration of vinegar (1%) was no more effective than hot water alone. Malt vinegar (4–8% acetic acid) was effective down to a dilution of 10%. Previously 5% acetic acid has been demonstrated to be effective at inactivating an A/H7N2 strain of influenza and it has been known for some years that acid-based media cause inactivation and aggregation of HA glycoprotein spikes and virus, by triggering the low pH-dependent conformational change in the HA that normally only occurs in late endosomes.

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3.4.1.3.13... Vinegar can decreased small intestine muscular thickness and abdominal fat

Jan. 3, 2018, study report Effect of probiotic and vinegar on growth performance, meat yields, immune responses, and small intestine morphology of broiler chickens: 30 day-old broiler chicks drinking water diluted vinegar significantly decreased small intestine muscular thickness (MT) and abdominal fat.

3.4.1.3.14... Vinegar has anti-obesity and anti-inflammatory effects

Jul. 27, 2017, study report Anti-obesity and anti-inflammatory effects of synthetic acetic acid vinegar and Nipa vinegar on high-fat-diet-induced obese mice: vinegar reduced lipid deposition, improved the serum lipid profile, increased adipokine expression and suppressed inflammation in the obese mice.

3.4.1.3.15... Vinegar may be as an adjunct treatment modality for Diabetes 

May 6, 2015, study report Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes: vinegar reduces postprandial hyperglycaemia, hyperinsulinaemia, and hypertriglyceridaemia without affecting lipolysis. Vinegar's effect on carbohydrate metabolism may be partly accounted for by an increase in glucose uptake, demonstrating an improvement in insulin action in skeletal muscle.

3.4.1.3.16... Apple Cider Vinegar can thin sticky mucus and clears stuffy noses

Sep 10, 2017, on the website; Lung Health Institute posts article Apple Cider Vinegar and COPD: Clears Stuffy Noses – Apple cider vinegar contains potassium that thins mucus. Also, the acidic PH prevents bacteria growth. Directions: Mix a teaspoon of apple cider vinegar with a glass of water and drink.

3.4.1.3.17... Apple Cider Vinegar can increases oxygen in blood stream

In Jan 15, 2021, I found an article Nine Benefits of Apple Cider Vinegar; it said that Apple Cider Vinegar can increases oxygen as it releases iron from the food you eat into your blood stream supplying more oxygen throughout the body.

3.4.1.3.18... Apple Cider Vinegar promotes oxygen to cells by promoting hemoglobin and myoglobin

Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. This is important because iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.

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3.4.1.3.19... Apple Cider Vinegar promotes energy consumption and leads to weight loss

Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. The iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.

Just as oxygen is essential to burn a fire in your fireplace, oxygen is also essential to burn energy (calories) in your body. Because apple cider vinegar helps the body release iron, it also helps your body's ability to burn calories, which is critical for weight loss.

Iron absorption leads to oxygen utilization, which leads to energy consumption, which leads to weight loss.

3.4.1.3.20... Apple Cider Vinegar promotes energy consumption and leads to weight loss

Dec. 6, 2013, articel The Surprising Benefits of Apple Cider Vinegar said that apple cider vinegar helps release iron from the food you eat, so it can be used throughout the body. The iron is a key component of hemoglobin and myoglobin. Both hemoglobin and myoglobin are responsible for carrying oxygen to cells throughout the body.

Just as oxygen is essential to burn a fire in your fireplace, oxygen is also essential to burn energy (calories) in your body. Because apple cider vinegar helps the body release iron, it also helps your body's ability to burn calories, which is critical for weight loss.

Iron absorption leads to oxygen utilization, which leads to energy consumption, which leads to weight loss.

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3.4.1.3.21... Vinegar reduces body weight, body fat mass, and serum triglyceride levels

Aug. 7, 2009, Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects:

Acetic acid (AcOH), a main component of vinegar, recently was found to suppress body fat accumulation in animal studies. Hence we investigated the effects of vinegar intake on the reduction of body fat mass in obese Japanese in a double-blind trial.

The subjects were randomly assigned to three groups of similar body weight, body mass index (BMI), and waist circumference. During the 12-week treatment period, the subjects in each group ingested 500 ml daily of a beverage containing either 15 ml of vinegar (750 mg AcOH), 30 ml of vinegar (1,500 mg AcOH), or 0 ml of vinegar (0 mg AcOH, placebo). Body weight, BMI, visceral fat area, waist circumference, and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group. In conclusion, daily intake of vinegar might be useful in the prevention of metabolic syndrome by reducing obesity.

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3.4.1.3.22... Vinegar lower blood sugar and insulin levels in people with diabetes

Oct. 6, 2018, article Is Vinegar Good for You said that: In a 2015 Greek study of 11 people with diabetes, those who had an ounce of vinegar and then consumed a ham and cheese sandwich, orange juice, and a cereal bar had slightly lower blood sugar and insulin levels afterward than those who drank water instead of vinegar.

3.4.1.3.23... Vinegar prmotes insulin-producing cells and slows atherosclerosis

In a few very small studies, gourmet-quality balsamic vinegars improved the function of insulin-producing cells in the pancreas in rats and slowed atherosclerosis-promoting damage to LDL cholesterol in a tiny Japanese study with five people. But there’s no research suggesting inexpensive balsamic vinegar has the same effects.

3.4.1.3.24... Apple Cider Vinegar can improve Sleep

Oct. 12, 2020, article Apple Cider Vinegar for Sleep: Fact or Fiction said that “The acetic acid content of apple cider vinegar aids digestion by helping to hasten the breakdown of protein-rich foods. This digestive process, in turn, produces amino acids like tryptophan, which can enhance the production of hormones like serotonin and melatonin that induce and improve sleep.”

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3.4.1.3.25... Vinegar has sober-up effect

2002 Jun. 27, 2002, article Study on sober-up effect of crystal sugar-vinegar solution said that Crystal sugar-vinegar solution could prolong the latent period of righting reflex disappearing of the drunk mice(P < 0.01) and decrease death percentage of drunk mice in 24 hours(P < 0.01). Crystal sugar-vinegar could also decrease blood alcohol levels in the drunk rabbits, especially 30 min(P < 0.01) and 180 min(P < 0.05) after administration of alcohol. Conclusion: Crystal sugar-vinegar solution has an evident sober-up effect on drunk model animal.

3.4.1.3.26... The medicinal application in TCM

In ancient time, vinegar has been widely used in TCM: promote digestion; improve appetite; kill roundworms; eliminate carbuncle swelling; nourish liver; strengthen muscles; sober up drunkenness; relieve anxiety; dispel blood stasis; stop bleeding; detoxify; kill insects; treat fainting; nourish lungs; stop diarrhea; treat postpartum haemorrhage; treat jaundice; stop yellow sweat; stop vomiting blood; stop epistaxis; stop blood in stool; treat genital itching, treat carbuncle and sore, relieve poison in fish, meat and vegetable; and so on.

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3.4.1.3.27... Vinegar’s functions on health: constituents, sources, and formation mechanisms

Sep. 28, 2016, Vinegar Functions on Health: Constituents, Sources, and Formation Mechanisms: “Vinegars are one of only a few acidic condiments throughout the world. Vinegars can mainly be considered grain vinegars and fruit vinegars, according to the raw materials used.”

Functional ingredients: Organic acids; Ligustrazine; Dihydroferulic acid; Dihydrosinapic acid; Tryptophol;  Melanoidins; Ligustrazine.

Physiological functions: antibacteria, anti-infection, antioxidation, blood glucose control, lipid metabolism regulation, weight loss, and anticancer activities.

“The antibacteria and anti-infection abilities of vinegars are mainly due to the presence of organic acids, polyphenols, and melanoidins. The polyphenols and melanoidins also provide the antioxidant abilities of vinegars, which are produced from the raw materials and fermentation processes, respectively. The blood glucose control, lipid metabolism regulation, and weight loss capabilities from vinegars are mainly due to acetic acid. Besides caffeoylsophorose (inhibits disaccharidase) and ligustrazine (improves blood circulation), other functional ingredients present in vinegars provide certain health benefits as well.”

“Regarding anticancer activities, several grain vinegars strongly inhibit the growth of some cancer cells in vivo or in vitro, but related functional ingredients remain largely unknown, except tryptophol in Japanese black soybean vinegar. Considering the discovering of various functional ingredients and clarifying their mechanisms, some vinegars could be functional foods or even medicines, depending on a number of proofs that demonstrate these constituents can cure chronic diseases such as diabetes or cardiovascular problems.”

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3.4.1.3.28...Apple cider vinegar can help epilepsy

July 1, 2018, Youtube video Apple Cider Vinegar Helped my Epilepsy SO MUCH!

Vanessa Duncan: I have partial complex epilepsy and I started taking apple cider vinegar for a completely different reason I started taking apple cider vinegar because I was having stomach issues just bloating stomach and stress. I took one tablespoon of apple cider vinegar to eight ounces of ice water and I did that three times a day.

I'm a person that has what's considered uncontrolled epilepsy; after drinking apple cider vinegar, my epilepsy improved a lot.

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3.4.1.3.29... Drink Vinegar increases immune cells in the blood of mice

2001, article The effect of cider vinegar on some nutritional and physiological parameters in mice reports that groups of female ICR (CD-1) mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks. Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg while others showed no significant differences in weight gain. The mean dry matter intake increased in animals treated with the smallest dose and significantly decreased in others. Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups. The activity of liver aspartate amino transferase (AST) decreased in the group treated with the smallest dose while no significant variations were recorded in the other groups. No significant differences were recorded neither in the activity of hepatic alanin amino transferase (ALT) nor in hepatic acid phosphatase (ACP). Liver alkaline phosphatase (ALP) noticeably elevated only in animals treated with 0.51 ml of vinegar/kg body weight per day. Treated groups also showed statistically significant increases in both mean liver and spleen weight. Kidney weight did not show significant differences.

High doses of cider vinegar induced histopathological alterations in liver, stomach and duodenum. Vacuolated hepatocytes, erosion of gastric mucosa, dilatation in gastric glands and duodenum villus blunting are the common observed lesions noticed in organs of high dose-treated animals.

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3.4.1.3.30... Daily vinegar intake can reduce depression by up to 34%

Nov. 18, 2021, Daily vinegar intake can reduce depression by up to 34%: The main component of vinegar is acetic acid, which has an antioxidant role in biological systems, such as the brain, this suggests vinegar may improve mental function by providing an exogenous source of acetate (a metabolite and derivative of acetic acid).

Evidence from a study on rats? demonstrated a reversal in cognitive decline with acetate supplementation, however the effect of increased serum acetate from exogenous sources (including vinegar) is under-researched in humans, according to the researchers behind the current study.

Vinegar and brain health?

The current placebo-controlled, randomised, parallel arm study, conducted by a team at Arizona State University, in the US, examined the impact of daily vinegar ingestion on mood states and urinary metabolites in 25 healthy college students.

Participants in the active study arm ingested two tablespoons of vinegar (Braggs, Liquid Apple Cider Vinegar) diluted in one cup water twice daily with meals for four weeks, and participants in the control arm consumed one vinegar tablet (General Nutrition Corporation Apple Cider Vinegar tablets) daily for four weeks. The liquid vinegar treatment provided 1.5 g acetic acid daily in comparison to the vinegar tablet that provided 0.015 g acetic acid daily.

A spot urine sample from the first morning void was collected at baseline and at study week four.  Additionally, at baseline and at study week four, two validated, widely applied mood questionnaires were completed online: the Profile of Mood States (POMS) and the Center for Epidemiological Studies-Depression (CES-D) questionnaires.

Resulting data confirmed an increase in 10 of the 17 significant between-group metabolites in the liquid vinegar (VIN) group and a 20-34% reduction in self-reported depression scores in the same participants while there were slight increases in the control (CON) group.

Metabolomics data compiled by the team showed several metabolic alterations associated with apple cider vinegar ingestion and consistent for improved mood, including enzymatic dysfunction in the hexosamine pathway.

Scientists also noted an increase in glycine, serine, and threonine metabolism in the VIN group. Threonine increases glycine in the brain which, along with serine, impacts neurological health (brain function), they say.

The report states: “Serine has a role in the synthesis of sphingolipids and glycolipids which are important myelin constituents and also enhances dendritogenesis and axon lengths. Glycine is a neurotransmitter with trophic effects on neurons and a substrate in the synthesis of sarcosine.”?

Scores from the CES-D baseline questionnaires suggested five VIN participants and four CON participants had elevated risks of suffering depression, while baseline results for POMS revealed one participant in each group below normative scores.

There were marginal changes to CES-D scores at week four with a reduction in the VIN group and an increase in the CON group. Conversely, individual mood states differed significantly for depression at week four. Mood scores improved in all categories in the VIN group but were consistently down in the CON group.

Conclusion?

The scientists postulate that the study provides valuable insights into possible impacts of exogenous acetic acid on metabolism and suggest daily apple cider vinegar ingestion can lower depression scores in healthy college students under controlled conditions.

“With over 40% of college students self-reporting moderate-to-severe depression, a 77% increase over the past decade, simple and safe strategies that effectively reduce depression in this population are urgently needed," ?the report states. "These data warrant continued investigation of vinegar as a possible agent to improve mood state.”?

However, they add that results may vary depending on the phytochemical profiles of the vinegar ingested and say the data warrants further investigation to underpin the evidence of vinegar as a possible agent to improve mood state.

Source: Nutrients?

Published online at: http://doi.org/10.3390/nu13114020?

“Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial”

Nutrients. 2021 Nov; 13(11): 4020.

Published online 2021 Nov 11. doi: 10.3390/nu13114020

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3.4.1.4... Hypochlorous acid will be potential medication by electronegativities of oxygen and chlorine atom

Perhaps, before, people only pay attention to the antitoxic effect of hypochlorous acid, its harm for human health, and seldom pay attention to its positive physiological and therapeutic effects. Its therapeutic effect should be similar to vinegar.

Jan 15，2010, Hypochlorous acid: a natural adjuvant that facilitates antigen processing, cross-priming, and the induction of adaptive immunity

June 2, 2020, Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines

29 April 2022, Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer

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3.4.1.5... Chlorine dioxide will be potential medication by electronegativities of Oxygen atom and Chlorine atom

The use of Chlorine dioxide as drug is initiated by Jim Humble. 27 June 2017, on his Blog he made a post A word from Jim Humble. https://jimhumble.co/?fbclid=IwAR0TUKhFQ-SZv7nfzFVF3wfIzxDi2XJdOzKx4x-DaB-7CzO8kvEymhxJH2E

“I want to tell you about a breakthrough that can save your life, or the life of a loved one. In 1996, while on a gold mining expedition in South America, I discovered that chlorine dioxide quickly eradicates malaria. Since that time, it has proven to restore partial or full health to hundreds of thousands of people suffering from a wide range of disease, including cancer, diabetes, hepatitis A, B, C, Lyme disease, MRSA, multiple sclerosis, Parkinson’s, Alzheimer’s, HIV/AIDS, malaria, autism, infections of all kinds, arthritis, high cholesterol, acid reflux, kidney or liver diseases, aches and pains, allergies, urinary tract infections, digestive problems, high blood pressure, obesity, parasites, tumors and cysts, depression, sinus problems, eye disease, ear infections, dengue fever, skin problems, dental issues, problems with prostate (high PSA), erectile dysfunction and the list goes on. This is by far not a comprehensive list. I know it sounds too good to be true, but according to feedback I have received over the last 20 years, I think it’s safe to say MMS has the potential to overcome most diseases known to mankind.”

“It is important to note that MMS does not cure disease. MMS is an oxidizer, it kills pathogens and destroys poisons. When these are reduced or eliminated in the body, then the body can function properly and thereby heal. I often say, “The body heals the body”. MMS helps to line things up so the body can do just that.”

“I have done many things in my lifetime—gone from a backwoods boy in Alabama, to the Marines, to a nutritional and alternative health enthusiast, to Aerospace, to electronics researcher, to inventor (of many things), to gold mining. Realizing I found “real gold” when I discovered MMS, from that point on I’ve dedicated all my time and effort to helping others recover their health and to bringing this technology to the world. It is my mission to bring this knowledge of health recovery to mankind. All profits from the sales of my books go towards this mission.”

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The studies about the therapeutic effect of Chlorine dioxide

The LD50 of chlorine dioxide is 292 mg/kg in rat, oral, LC50 is 0.29 mg/L by inhalation. I infer that the safe and effective dose for medicinal use of chlorine dioxide should be 300 - 600mg/50kg in 4 times daily; by comparison with that of vinegar; the effect of chlorine dioxide is more powerful.

3.4.1.5.1... The mechanism of chlorine dioxide kill occurs via disruption of protein synthesis

Mar.1967, article Kinetics and Mechanism of Bacterial Disinfection by Chlorine Dioxide said that survival data are presented for a fecal strain of Escherichia coli exposed to three concentrations of chlorine dioxide at four temperatures. Chick's first-order reaction equation is generalized to a pseudo nth-order model. Nonlinear least squares curve-fitting of the survival data to the nth order model was performed on an analogue computer. The data were observed to follow fractional order kinetics with respect to survival concentration, with an apparent activation energy of 12,000 cal/mole. Initial experiments support the thesis that the mechanism of chlorine dioxide kill occurs via disruption of protein synthesis.

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3.4.1.5.2... Chlorine dioxide is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite

Dec.2021, article Chlorine dioxide is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite said that by concentrated SARS-CoV-2 viruses were treated with various concentrations of ClO2 and sodium hypochlorite and 50% tissue culture infective dose was calcurated to evaluate the antiviral activity of each chemical.

Findings: When SARS-CoV-2 viruses were treated with 0.8 ppm ClO2 or sodium hypochlorite, viral titre was decreased only by 1 log10 TCID50/mL in 3 min. However, the viral titre was decreased by more than 4 log10 TCID50/mL when treated with 80 ppm of each chemical for 10 s regardless of presence or absence of FBS. It should be emphasized that treatment with 24 ppm of ClO2 inactivated more than 99.99% SARS-CoV-2 within 10 s or 99.99% SARS-CoV-2 in 1 min in the presence of 0.5% or 1.0% FBS, respectively. By contrast, 24 ppm of sodium hypochlorite inactivated only 99% or 90% SARS-CoV-2 in 3 min under similar conditions. Notably, except for ClO2, the other components of Cleverin such as sodium chlorite, decaglycerol monolaurate, and silicone showed no significant antiviral activity.

Conclusion: Altogether, the results strongly suggest that although ClO2 and sodium hypochlorite are strong antiviral agents in absence of organic matter but in presence of organic matter, ClO2 is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite.

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3.4.1.5.3... Chlorine dioxide is effective in the treatment of Covid-19

Mar. 2021, article Determination the Effectiveness of Dioxide in the Treatment of COVID19 reports that, research on the mechanism of action of chlorine dioxide on viruses, on the oral consumption of water-solubilized ClO2 and on its toxicity was reviewed; a quasi-experimental investigation was conducted on the use of oral water-soluble chlorine dioxide in the treatment of 20 patients with active COVID-19 infection, compared to a control group of 20 patients not treated with chlorine dioxide.

The administration protocols

10 ml of chlorine dioxide 3000 ppm is added to 1 liter of water, and the liter is taken in two hours, divided into eight (8) equal doses. Then it is administered. Maintenance protocol: (C) 10 ml of chlorine dioxide 3000 ppm is added to 1 liter of water, and the liter is given to drink divided into ten (10) equal doses, during the day, every hour.

Results: To compare the effect in the experimental group versus the control group, a paired test was performed using the Wilcoxon-Mann-Whitney test (α: 95%).

Within the experimental group, a significant difference was observed in all general symptoms when comparing day 0 to day 07. Some even disappeared after day 7. Those values that did not disappear completely on day 7 did not differ from those on days 14 and 21 (p>0.05). As for headache, it decreased very significantly (p<0.0001) from day 0 with respect to subsequent days. When comparing the experimental group with the control group on the seventh day post manifestation of symptoms, a significant difference was found in the experimental group with respect to the control group for the symptoms Fever (p: 0000), Cough (p: 0.0001), Chills (p: 0.0015) and Dyspnea (p: 0.0047). When performing the visual analogous comparison of pain in the control group and in the experimental group, it was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group.

On day 14 post manifestation the difference was greater (p<0.001). When evaluating both groups (Control and Experimental) in the laboratories, a difference was found for the values for the parameters PC Reactive (p: 0.0398) and DH Lactate (0.0422), with higher scores for the experimental group; no difference was found in the rest of the parameters. The results in general (p<0.05) demonstrate the hypothesis that chlorine dioxide is effective in the treatment of COVID-19. It was found that in all the items that make up the scale decreased significantly in this group with respect to the Control group. On day 14 post manifestation the difference was greater (p<0.001).

Conclusion: Chlorine dioxide is effective in the treatment of COVID-19 and the mechanisms of action by which it acts to achieve it are proposed in this work. We recommend doing more research. We recommend conducting double-blind studies and delving into studies of toxicological safety and therapeutic efficacy of chlorine dioxide in pathologies of epidemiological impact in the near future.

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3.4.1.5.4... The rats expose in low level chlorine dioxide gas continuously for six months was not toxic

Feb. 21, 2012，Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats reports that Chlorine dioxide (CD) gas has a potent antimicrobial activity at extremely low concentration and may serve as a new tool for infection control occupationally as well as publicly. However, it remains unknown whether the chronic exposure of CD gas concentration effective against microbes is safe. Therefore, long-term, low concentration CD gas inhalation toxicity was studied in rats as a six-month continuous whole-body exposure followed by a two-week recovery period, so as to prove that the CD gas exposed up to 0.1 ppm (volume ratio) is judged as safe on the basis of a battery of toxicological examinations.

Methods: CD gas at 0.05 ppm or 0.1 ppm for 24 hours/day and 7 days/week was exposed to rats for 6 months under an unrestrained condition with free access to chow and water in a chamber so as to simulate the ordinary lifestyle in human. The control animals were exposed to air only. During the study period, the body weight as well as the food and water consumptions were recorded. After the 6-month exposure and the 2-week recovery period, animals were sacrificed and a battery of toxicological examinations, including biochemistry, hematology, necropsy, organ weights and histopathology, were performed.

Results: Well regulated levels of CD gas were exposed throughout the chamber over the entire study period. No CD gas-related toxicity sign was observed during the whole study period. No significant difference was observed in body weight gain, food and water consumptions, and relative organ weight. In biochemistry and hematology examinations, changes did not appear to be related to CD gas toxicity. In necropsy and histopathology, no CD gas-related toxicity was observed even in expected target respiratory organs.

Conclusions: CD gas up to 0.1 ppm, exceeding the level effective against microbes, exposed to whole body in rats continuously for six months was not toxic, under a condition simulating the conventional lifestyle in human.

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3.4.1.5.5... Chlorine Dioxide ClO2 is effective on airborn, enteric and Bloodborne Viruses

Aug 12，2021, article Effectiveness of Disinfection with Chlorine Dioxide on Respiratory Transmitted, Enteric, and Bloodborne Viruses: A Narrative Synthesis reports that: A viral spread occurrence such as the SARS-CoV-2 pandemic has prompted the evaluation of different disinfectants suitable for a wide range of environmental matrices. Chlorine dioxide (ClO2) represents one of the most-used virucidal agents in different settings effective against both enveloped and nonenveloped viruses. This narrative synthesis is focused on the effectiveness of ClO2 applied in healthcare and community settings in order to eliminate respiratory transmitted, enteric, and bloodborne viruses.

Influenza viruses were reduced by 99.9% by 0.5–1.0 mg/L of ClO2 in less than 5 min. Higher concentration (20 mg/L) eliminated SARS-CoV-2 from sewage. ClO2 concentrations from 0.2 to 1.0 mg/L ensured at least a 99% viral reduction of AD40, HAV, Coxsackie B5 virus, and other enteric viruses in less than 30 min. Considering bloodborne viruses, 30 mg/L of ClO2 can eliminate them in 5 min. Bloodborne viruses (HIV-1, HCV, and HBV) may be completely eliminated from medical devices and human fluids after a treatment with 30 mg/L of ClO2 for 30 min. In conclusion, ClO2 is a versatile virucidal agent suitable for different environmental matrices.

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3.4.1.5.6... Oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate was relative safety

Dec. 1982, Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man.

To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising dose tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5 mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was assessed by evaluation of a battery of qualitative and quantitative tests.

The three phases of this controlled double-blind clinical evaluation of chlorine dioxide and its potential metabolites in human male volunteer subjects were completed uneventfully. There were no obvious undesirable clinical sequellae noted by any of the participating subjects or by the observing medical team. In several cases, statistically significant trends in certain biochemical or physiological parameters were associated with treatment; however, none of these trends was judged to have physiological consequence. One cannot rule out the possibility that, over a longer treatment period, these trends might indeed achieve proportions of clinical importance.

By the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated.

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3.4.1.5.7... Chlorine Dioxide used as a Non-Toxic Antimicrobial Agent for Virus, Bacteria and Yeast

October 8, 2016, article Chlorine Dioxide (CLO2) As a Non-Toxic Antimicrobial Agent for Virus, Bacteria and Yeast (Candida Albicans) reports that CLO2 is an inorganic compound composed of oxygen; chloride; potassium and gold. Compounds of oxygen and chloride are formed from two electronegative elements. This chemical property of CLO2 makes possible the release of nascent oxygen upon decomposition during its action as an anti-microbial agent. Certain aspects of the cellular immune system (specifically white blood cells) utilize other mechanisms in the generation of highly reactive oxygen derivatives (free radicals) for the purpose of combating the invasion of foreign organisms. Without these protective mechanisms provided by the immune system involving oxygen derivatives; the ability to fight infection is greatly impaired.

The immune system of many persons; particularly the elderly; is deficient in the ability of providing these highly reactive oxygen derivatives (free-radicals) which are so necessary for attacking the great variety of viral; and bacterial invaders become easy targets for the many diseases they produce with the accompanying and sometimes bizarre symptoms.

The use of CLO2 assists the natural protective mechanisms of the body in counteracting these infectious agents which; if not adequately neutralized; will most certainly lead to disease. There will be described below the biochemical mechanisms by which CLO2 assists the immune system in destroying pathogenic organisms by making available an active form of oxygen.

Clinical Applications of Anti-Microbial Agents

Virus inactivation

A virus typically consists of an outer shell or coating of protein encapsulating a nucleic acid which may be either DNA or RNA (e.g. Retroviruses). The skeletal backbone of nucleic acids includes derivatives of phosphoric acid (H3PO4; a very strong acid) in which two of the original three hydroxyl groups (-OH) are substituted; leaving only one active hydroxyl group per phosphate.

Segment of extended DNA chain showing alternating deoxyribose- phosphate linkage

Some viruses may have glycoproteins incorporated into their protein coat; that is; proteins to which polysaccharides (sugar chains) have been attached. The bound polysaccharides may attach to specific sites on the protein coat; effectively converting a protein surface into a poly- sugar surface. This new surface has specificity for certain polysaccharides found on the surfaces of specific cell types; thereby conveying specificity to virus binding as well as a degree of immunological protection.

Once bound to the appropriate cell type; the nucleic acid component of the virus is injected into the cell and in many ways; takes over the protein synthesis processes of the cell. Certain segments of the viral nucleic acid consist of genes that are responsible for the replication of the coat. The nucleic acid component replicates by a process known as “base-pairing”; in which each base of the original strand attracts and binds the corresponding base; forming a pair (A-T and C-G; described more fully below) through hydrogen bonding. The result is the replication of the complete virus until the cell bursts; releasing many additional viral particles into the surrounding medium. In the presence of these acidic nucleic acids; the CLO2 molecule becomes unstable and releases nascent oxygen into the medium.

Nucleic acids; both RNA and DNA; have many characteristics in common; in fact; they are almost chemically identical. Each consists of a chain of alternating sugar (a modification of ribose; deoxyribose) and phosphate groups; known as the “phosphate-sugar backbone”. Attached to a specific carbon of each deoxyribose group is an organic ring compound known as a “base”. Altogether; there are only four types of bases found in DNA; namely; guanine (G); cytosine (C); adenine (A) and thymine (T). It is the sequence of these four units along the chain that makes one segment of DNA differs from another. RNA differs chemically from DNA in that the base thymine is replaced by the base uracil (U); representing a very subtle biochemical difference. There is also a subtle difference in the sugar deoxyribose.

The release of nascent oxygen from chlorine dioxide CLO2 in an acidic environment

The base guanine; found in both RNA and DNA; is very sensitive to oxidation; forming 8-oxoguanine as the oxidation product. The release of CLO2 results in the oxidation of the guanine residue with the formation of 8-oxoguanine; thereby disallowing the replication of the viral nucleic acid by base pairing. Although the replication of the protein coat may continue; the formation of a complete functional virus has been blocked by CLO2 oxidation.

CLO₂ as an antifungal agent

Fungi are considered as plants without chlorophyll and lack the ability to generate carbohydrates from sunlight and carbon dioxide. They were probably derived in an oxygen-free atmosphere but some have developed the ability to tolerate low levels of oxygen. Most fungi prefer an oxygen-poor environment and live best under these conditions. They obtain their energy requirements from the decomposition (through enzyme activity) of existing organic matter and; in this light; may be considered as parasitic.

Because of their low tolerance for nascent oxygen and the acidic medium in which they thrive (from the liberation of organic acids); fungi in the mycelial form are sensitive to the destructive action of CLO₂. One example of a human pathogenic fungus is Candida albicans; invading finger and toenails. A second example is the fungus responsible for “atheletes foot”; thriving between toes in a moist environment while still another example is “ringworm”; propagating on the dead cells found on skin (as well as generating many mycotoxins affecting homeostasis).

Cytotoxicity of CLO₂

Proof that CLO₂ is cytotoxic to bacteria; fungus and virus clinically is shown by data indicating its effectiveness as a disinfectant (outside the body). CLO₂ has been found to inactivate the organism causing Legionnaire’s Disease (Legionella pneumophila). The chemically related compound sodium per iodate (NaIO4) inhibited the virulence; decreased the respiration of and increased the sensitivity to phagocytosis of the common pathogen Listeria monocytogenes.

A germicidal solution has been developed containing CLO₂ at an acid PH (lactic acid). The solution gave complete kill of Staphylococcus aureus; Pseudomonas and Candida albicans spores within 10 minutes. If used in an ultrasound cleaning device complete killing occurred in less than five minutes. The bacterial virus ￡2 was rapidly inactivated with CLO₂ at pH 5.9 only GMP (guanosine monophosphate) reacted while the amino acids cystine; tryptophan and tyrosine reacted rapidly.

CLO₂ applied to polio virus separated the RNA from the protein coat (capsid). CLO₂ reacted with the capsid protein and prevented the adsorption; penetration and normal un-coating of the virus. It also reacted with the viral RNA and impaired the ability of the nucleic acid to act as a template for replication.

Fate of CLO₂ following ingestion

The half-life for the elimination of CLO₂ from experimental animals (rat) was 43.9hours. When rats drinking 100mg of CLO₂ per liter for 15days were then given 3ml of 300mg/liter orally the half-life was 31hours.

The distribution of CLO2 in tissues following administration of CLO2 labelled material is as follows

Plasma; 2.74; Kidney; 2.45; Lung; 2.25; Stomach; 2.15; Liver; 1.16; Spleen; 0.76; Thymus; 0.68. The metabolites of CLO₂ are chlorite (CLO₂); chlorate (CIO₃); chloride (CL) and oxygen (O2).

Toxicity of CLO₂

It has been shown by toxicity studies in man that daily ingestion of 500ml CLO₂ having a concentration of 5ppm is safely tolerated. In other studies with rats the LD of NaCLO₂ was established as 140mg/kg. In studies where CLO₂; Na CLO₂ or CIO₃ was included in the drinking water for up to several months where no significant increases in methemoglobin concentrations resulted with doses as high as 1000mg/liter (1000ppm) in the rat; mouse or chicken.

CL02 in wound healing

It has been demonstrated clinically that CLO₂ is highly effective in accelerating wound healing with particular applications to burns. There may at first be no apparent explanation for such a relationship but careful biochemical analysis has revealed a mechanism of action relating CLO₂ to wound healing. Nucleic acids (RNA and DNA) are formed of only four basic units linked together into a chain. One of the basic units is designated; guanosine monophosphate; or GMP. If the phosphate group is brought close to one of the hydroxyl groups of the sugar component ribose; water is eliminated and the product is known as cyclic GMP (cGMP).

It has been shown that cGMP stimulates cell division and is activated during the regeneration process. It is also known that the enzyme synthesizing cGMP; guanylate cyclase; is stimulated by one of the highly reactive oxygen derivatives; hydroxyl radical; symbolized by OH-. An oxidizing agent chemically similar to CLO₂ is periodic acid; HIO4; in which four oxygen atoms are bound to a single halogen atom; iodine. In CLO₂; two oxygen atoms are bound to the halogen chlorine. It has been determined that hydroxyl radical is present in solutions of periodic acid and; by inference; may also be present in solutions of CLO₂. The presence of hydroxyl radicals in CLO₂ activates the enzyme guanylate cyclase; which; in turn; synthesizes cGMP leading to cell proliferation and wound healing.

The significance of candida albicans in therapy with CLO₂

Candida albicans is a normal resident of the human digestive system; and vaginal tract and; unlike many other yeasts; is found in two forms (dimorphic). Baker’s or brewers yeast is a familiar example of a yeast which occurs in only one form; that of single ovoid-shaped cells which reproduce by the process of “budding.” An older; large cell constricts near one end and eventually closes off thereby forming a daughter cell which breaks free and continues the reproductive cycle.

Candida albicans is said to be “dimorphic” because the ovoid single-cell may; under certain conditions; continue to elongate into an almost perfect cylinder (mycelium); occasionally laying down a wall or partition separating individual cells. This process is also accompanied by branching in which a new tube may start to grow laterally from a specific point. By changing the culture conditions the form of Candida albicans may be changed from one form to the other and vice versa. This phenomena is known as pleomorphism.

It is believed that only the mycelial form is pathogenic in man; who will be discussed in greater detail below. The incidence of both superficial and invasive candidosis has been increased markedly over the last few decades; probably resulting from the widespread usage of immunosuppressive treatment; antibiotics; etc. The organism can reasonably be described as the most common and most serious fungal pathogen of man.

Candida albicans has a worldwide distribution and is commonly found in normal individuals. The incidence of this fungus in various groups undergoing medical treatment is in general higher. Candida vaginitis is at present the second most common form of vaginal infection in the United States. Of the women who develop vaginal candidosis; a significant proportion suffer frequent recurrences or show chronic intractable symptoms. Candida albicans can infect virtually every tissue in the human body. Clearly there is a requirement for new and more effective antifungal drugs.

For Candida albicans to successfully colonize and infect mucosal surfaces it has to adhere to epithelial surfaces. In germ free animals the mucosa is colonized in higher numbers than in that of control animals (normal). These results suggest that the indigenous bacterial flora suppresses Candida albicans colonization. This; in turn; implies that at least one factor contributing to Candida albicans infection may be the balance between the various components of the intestinal flora.

Antiviral activity of CLO₂

Viruses; in general; consist of two parts; an inner nucleic acid core consisting of either; DNA or RNA; and an outer protein coat. The protein coat not only serves to protect the vital nucleic acid within but is also instrumental in providing specificity in binding to the surface of particular cells (polio virus binds to nerve cells; influenza virus binds to the nasal mucosa; etc.). It has also been shown that without certain specific polysaccharides attached to the protein coat (glycoproteins); binding to the cell surface will not occur.

Biochemical activity of CL02

The action of CLO2 as a cytotoxic agent may include as many as four separate biochemical mechanisms described below.

Oxidation of protein

As mentioned above; the protein coat is highly significant in viral infectivity and provides specificity for binding to the proper cell type. Two amino acids that would undergo oxidation and modification to a significant enough degree to permit inhibition of virus to cell binding are those containing sulfur; namely; methionine and cysteine.

The residue of methionine; -CH^CH^CRj; contains the C-S-C thioether linkage subject to oxidation in either one or two stages. In the first stage the binding of one atom of oxygen results in the formation of the sulfoxide -CH2CH3SCO2CH; having the ability to bind several molecules of water (hydrophilic). The parent compound; methionine; is hydrophobic (in relation to the residue). A subsequent stage of oxidation leads to the formation of the sulfone; -CH2CH2S(O2)CH; which is even more hydrohpilic than the sulfoxide. Both methionine sulfoxide and sulfone are well known modifications of this amino acid.

The modification of the water binding ability of a protein constituent (methionine) is highly significant in relation to the antiviral activity of CLO2. In transmission electron micrographs of virus which has been exposed to the action of CLO2 it appears that the outer coat has swollen much like a sponge. The increased penetration of water into the viral protein coat allows additional CLO2 (water soluble) to penetrate to still deeper layers of the coat; thus initiating a vicious cycle.

Oxidation of nucleic acid (RNA)

As mentioned above; CLO2 is capable of generating a variety of extremely reactive oxygen derivatives when acting as an oxidizing agent. Another example of an oxidizing agent releasing atomic or nascent oxygen is ozone; O3 this molecule consists of a chain of three oxygen atoms held together by covalent bonds. The release of one atom of oxygen results in stable; molecular oxygen; 0. The oxidizing activity of CLO2 is similar to that of ozone; liberating highly active forms of oxygen. Very detailed research has been described related to the oxidation of polio virus by ozone. Exposure of the virus RNA strand to ozone resulted in fragmentation into several short chains. The effect of ozone on the nucleic acid was measured spectrophotometrically indicating that inactivation was complete after only sixty seconds.

Nucleic acid comprising the RNA or DNA of viruses consists of a chain of four building blocks arranged in some specific sequence. It is the sequence of the four nucleotides (designated by the letters A; C; G and U for RNA) that causes one strand to differ from another resulting in the synthesis of specific proteins for each. When a mixture of the four nucleotides is exposed to ozone it is found that only the unit designated; G (guanine); is degraded in the initial stage. In the exposure of transfer RNA (tRNA) to ozone; guanine again was the first nucleotide to be degraded. Exposure of tobacco mosaic virus (TMV) to ozone caused a rapid loss of infectivity within 30 minutes showing a preferential degradation of guanine.

Oxidation of lipids

Some viruses are surrounded by a bilayer lipid membrane as described above. Any substance which acts to disrupt this membrane is an anti-viral agent for that virus since the membrane is essential for infectivity. CLO2 may act to disrupt this membrane by peroxidizing the unsaturated fatty acids found in the bilayer lipid membrane. The specific positioning of these unsaturations along the fatty acid chain is related to the integrity and fluidity of the membrane. The peroxidation of unsaturations results in the development ofhydrophilic (water seeking) groups in the central part of the fatty acid chain which causes distortion in the bilayer lipid membrane. This activity of CLO2 has not been demonstrated biochemically but is very apparent in the electron micrographs (transmission) of viral membrane disruption shown.

Clinical application of CLO₂

Ongoing research at the Innerlight Biological Research Foundation has been investigating the clinical usage of CLO₂ for the following applications for over twenty-five years.

Herpes I and HI

AIDS (HTLV-m)

Sty (eye)

Cold sores (herpes)

Shingles (herpes)

Warts

Cytomegalovirus

Polio

Influenza

Canker sore

Ear infection

Chronic bronchitis Sinusitis

Dandruff

Psoriasis

Strep throat

Pseudomonas Pneumonia

Peridontal disease

Bladder infections

Mycotic (Fungal)

Candida (systemic)

Candida (snails)

Candida (vaginitis)

Candida (oral; thrush)

Candida (gastrointestinal)

Ringworm Scleroderma

This research also includes nonspecific spores; bacteria and virus.

Clinical outcome studies of CLO₂

Extensive clinical applications of CLO₂ to Epstein-Barr virus (EBV); cytomegalovirus (CMV); hepatitis virus A; B; HIV (AIDS virus) and others are being used continually. The DNA of EBV within the virus itself is in a linear form. Sometime after infection; the ends are linked together; forming the circular form (episome). Once this form of DNA is firmly established; the cell is said to be in a latent state. The virus remains in this state in certain B-cells for the remainder of the patient’s life. About 10% of the B-cells are in the actively proliferating state. An Epstein-Barr clinical study was conducted in the American Biologics Medical Center over a four year period from 1992 to 1996.

Case load:There were 1207 patients treated with the Dioxychlor® protocol. 784 patients were female - 65%. 423 patients were male - 35%. Ages ranged from 16 to 52 years.

Initial status:High IgG serum titers ranged from 400 to 5800. Intensive treatment for 14 days. 

Nutritional Supplementation. Sodium Chlorite CLO₂.

Therapy (baseline):

Sodium chlorite CLO2- intravenous drip; 10 cc in 100 cc saline; daily

Intravenous studies in the 90's at the American Biologics Medical Center have established that 10 ml of 25;000 ppm of Sodium Chlorite CLO2 in 100 ml of physiologic saline administered over 30 minutes is a safe dosage level.

Sodium chlorite CLO₂- sublingual; 10 drops under tongue; twice daily.

Thymus extract (im) – weekly.

Vitamin C – 15 g parenteral (drip).

Results (averages):Minimun time clinical improvement: 3 days significant clinical improvement: 10 – 20 days Antibody (IgG); 90% reduction;<35 days].

Microbiological Laboratory Studies:

In 1986; the Microbiology Laboratory at Stanford University performed a series of tests showing the efficacy of CLO₂ in neutralizing a variety of viruses. The concentration of CLO₂ used was 0.75 ppm in all the studies.

The viruses included Herpes II; HTLV III and Cytomelagalovirus. The study also included the bacterium Pseudomonas. Electron micrographs show the complete eradication of the viruses and Pseudomonas following treatment.

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3.4.1.6...NaF reduced mortality percentage of influenza virus H0N1 in mice

Dec 1981，The effect of sodium fluoride on experimental influenza virus infection in mice: NaF was administered intranasally to mice, either as a single 0.1-ml dose (containing 100 gamma), one hour before inoculation of influenza virus A/PR8/34 (H0N1), or as four similar daily doses, the last drug application preceding virus inoculation by 1 hour. In both cases the drug treatment led to a marked reduction in the hemagglutinating titers recorded in lung suspensions, accompanied by a lower mortality percentage and by an increase in mean survival length.

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3.4.1.7... The physiological function for therapeutic potential of carbonate ion in calcium carbonate

Dec. 22, 2021, Israeli drug prevents 100% of COVID patients from deteriorating in trial

All 18 COVID-19 patients hospitalized with moderate or severe symptoms who received the drug Amor-18 developed by Israeli biotech company Amorphical recovered and were discharged in a few days, the company announced on Wednesday. Of the 19 individuals who were given a placebo, six had to be transferred to intensive care, and two died. As part of compassionate care, two other patients in a very serious condition were given the drug. Both recovered and were discharged.

Amor-18, which uses Amorphous Calcium Carbonate (ACC) as the main ingredient, was administered orally or by inhalation. As explained by the company, ACC has the ability to modulate acidic pH changes around each cell. These changes affect the capability of COVID-19 to penetrate the cells and replicate. This allows the drug to prevent the virus from spreading and thus the patients from deteriorating.

“We are excited about the results of the clinical trial, which bring real hope to COVID-19 patients in Israel and around the world, and are especially encouraging these days with the start of the fifth wave of the Omicron variant,” said Amorphical CEO Yossi Ben. “The drug we have developed is anti-inflammatory, safe and effective and it is easy to use.” He noted that Amor-18 will work against the entire SARS virus family, including all COVID variants.

A larger trial is already being conducted at the Ziv, Shamir, Kaplan and Mayanei Hayeshua medical centers in Israel. In the near future, the drug will be tested in other countries. Seven hospitals in Brazil have announced that they will participate, and other centers in Europe and the United States are expected to join soon.

Oct 17, 2017, Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming

Store-operated Ca2+ entry (SOCE) is the main Ca2+ influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by Ca2+ release-activated Ca2+ (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2. SOCE regulates many Ca2+-dependent signaling molecules, including calcineurin, and inhibition of SOCE or calcineurin impairs antigen-dependent T cell proliferation. We here report that SOCE and calcineurin regulate cell cycle entry of quiescent T cells by controlling glycolysis and oxidative phosphorylation. SOCE directs the metabolic reprogramming of naive T cells by regulating the expression of glucose transporters, glycolytic enzymes, and metabolic regulators through the activation of nuclear factor of activated T cells (NFAT) and the PI3K-AKT kinase-mTOR nutrient-sensing pathway. We propose that SOCE controls a critical “metabolic checkpoint” at which T cells assess adequate nutrient supply to support clonal expansion and adaptive immune responses.

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3.4.2... Drug concept revolution: The synergistic effect of compound medication will be god medicine

The best medication will come from the combination of multiple medicinals; the more medicinals combined the more therapeutic effect, the fewer side effects in regardless synthetic drugs or natural medicnals.

For thousands of years, TCM has identified about 11,146 plants, 1581 animals and 80 minerals as medicinal use and has accumulated nearly 100 thousands of experience-based formulas, which covering almost all known diseases.

The compound medication is the unique therapeutic method of TCM by putting many different natural medicinals together as one dose to target on different symptoms at the same time. Modern findings proved correctness of TCM in the basis of pharmacology, physiology and magic therapeutic effect.               

In 1980s, Germany carried out about 300 clinical studies with standardized phytopharmaceuticals. Accordingly published report Phytomedicine Research in Germany. The studies show that “these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneous advantage of being devoid of any adverse effects.” “The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating.”

Nov. 22, 2013, article Plant Nutrient 'Cocktail' Kills Breast Cancer Cells reports that “turmeric, soybeans, broccoli, grapes and tea. Individually, they were ineffective against cancer. But combined, they suppressed breast cancer cell growth in the lab by more than 80 percent, and eventually triggered the process leading to cell death.”

Sep. 2019, article Fruit flies live longer with combination drug treatment reports that if it is used individually, lithium, trametinib and rapamycin are able to extend the lifespan of the fruit flies by an average of 11%, but if by any two combined use can increase the lifespan around 30%, and all three combined can reach 48%.

Feb 7, 2022; University of Pennsylvania School of Medicine posts study New Antiviral Drug Combination Is Highly Effective Against SARS-CoV-2 to report that Researchers have identified a powerful combination of antivirals to treat COVID-19 by combining the drug brequniar with remdesivir or molnupiravir — both approved by FDA of the U.S. The findings, published this week in Nature, suggest that these drugs are more potent when used in combination than individually; the combining drugs also reduce the risk of resistance.

Jan 20, 2021, article Mechanism and material basis of Lianhua Qingwen capsule for improving clinical cure rate of COVID-19: a study based on network pharmacology and molecular docking technology reports that in 13 component drug Lianhua Qingwen capsule; there are total 160 active components produced therapeutic effects against COVID-19; through 57 target proteins, involving 35 signaling pathways and Toll-like receptor signaling pathway. The results of molecular docking showed that 83 chemical components had total scores no less than 5.0 for docking with 12 target proteins with high binding activities to form stable conformations.

Above studies show that the multi-medicinals by compound medication can produce synergistic interaction to increase the therapeutic effect and reduce side effect of each other; which has provided the new drug concept that best medication will come from the multi-combination of the medicinals; in regardless of synthetic or naturals; the more medicinals combined the stronger therapeutic effect the lower side effect; which proved correctness of the compound medication of TCM.                                                                                                                 

Also; any disease is in multi-lesions as syndrome and in the state of continuously developing; therefore, it is impossible to develop symptomatic drugs by making clear the cause of each symptom. It is necessary to follow the compound prescription of TCM; the multi medicinals will heal multiple lesions as that of the projectiles of a shotgun can hit multiple targets in a blind shot.     

The cured cases in Covid-19 are perfect matching the practice of TCM by focusing on the restoration of the physical balance of Yin and Yang as disease treatment.                                                                                                                         

The findings proved the existence of the basis in both physiology and pharmacology for the compound medication; which indirectly proved rationality of the theory of ancient philosophy Daoism guided TCM.

According to above findings, I would like to infer that, the best medication will come from the unlimited combination of medicinals.

The recovered cases in Covid-19 show that the curative effects were not from the virus killing, but were from the physical restoration.

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3.4.3... Drug concept revolution: Melatonin will be the God medicine by perfecting nutrition processing

Here, I need to special indicate the unique effect of Melatonin, besides promote sleep and avoid cytokine storm, it decisive health contribution is at that it can significantly improve intestinal probiotics microorganisms.

For sleeping a sober mind that is able to make my brain obedient for proper concentration as my will, I take 5 mg Melatonin daily, two weeks later; I surprisingly found that the stool becomes soft, well formed without constipation; and the volume reduced by about 50%.

My experience showed that melatonin can radically improve the digestion problems from long sit typing. By regularly taking Melatonin will be able to permanently optimize our digestive system - Gut to perfect nutrition supply.

I searched and found that improving intestinal microorganisms has therapeutic effects that cover the most of diseases.

Gut is second brain in producing 95% of Serotonin, neurons and most neurotransmitters

Studies show that Gut microbiota regulates intestinal function and health; also influence the immune and nervous systems.

Modern studies proved that human digestive system - Gut is second brain in producing 95% of Serotonin, neurons and most neurotransmitters, which means that we can treat diseases by improving the Gut-microbiome and thus there was reports that Nutrition Psychiatry is the future of mental health treatment.

Melatonin for the treatment of irritable bowel syndrome

2014, Melatonin for the treatment of irritable bowel syndrome: Melatonin was touted as a potential effective candidate for IBS treatment. Putative role of melatonin in IBS treatment include analgesic effects, regulator of gastrointestinal motility and sensation to sleep promoter.  Most studies utilized 3 mg at bedtime as the standard dose of trial, all studies had consistently showed improvement in abdominal pain, some showed improvement in quality of life of IBS patients.

2014, A Review of the Role of Melatonin in Irritable Bowel Syndrome; Studies specific to IBS-C and IBS-D can help to optimize therapy. Doses of 3 to 8mg have been proven to be effective in patients with IBS-C. Doses of 3mg of melatonin prolonged colonic transit time, which could prove beneficial in patients with IBS-D. Available literature shows a positive correlation between the use of melatonin and symptom relief in IBS symptoms, thereby identifying it as a promising future treatment.

Melatonin increased Akkermansia muciniphila and Lactobacillus

Jun 23, 2020, article Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation reports that Stress is closely related to the deterioration of digestive disease. Melatonin has potent anti-inflammatory properties. Compared to the control, melatonin concentration was lower in the water stress (WS) and sleep deprivation (SD). After melatonin treatment, melatonin concentrations in feces and colon tissue were recovered to the level of control. Metagenomic analysis of microbiota showed abundance in colitogenic microbiota in WS and SD. Melatonin injection attenuated this harmful effect.

WS and SD showed decreased Lactobacillales and increased Erysipelotrichales and Enterobacteriales. Melatonin treatment increased Akkermansia muciniphila and Lactobacillus and decreased Bacteroides massiliensis and Erysipelotrichaceae. Stress and SD could affect intestinal dysbiosis and increase colitogenic microbiota, which could contribute to the aggravating digestive disease. Melatonin concentrations in feces and colon tissue decreased under WS and SD. Melatonin treatment brought recovery of melatonin concentration in colon tissue and modulating dysbiosis of intestinal microbiota.

Nov. 12, 2021, a report that the colorectal cancer is third most common cancer worldwide and the second leading cause of cancer death according to GLOBOCAN 2020. The daily diet is the main inducement of colorectal cancer through affecting gut microbial activities. Such as, high intakes of low-calorie beverages, French fries, red meats, and processed meats and low intakes of fruits and vegetables was associated with increased risk of colorectal cancer, after controlling for various risk factors.

Transplanting of gut flora from healthy mice cured sick mice

Studies show that Gut flora has magic therapeutic effect. Lab and clinical studies show that the transplanting of gut flora from healthy mice cured sick mice. Mother’s gut flora transplants to newborn to have prevented the baby from getting sick. Cancer patients who developed drug resistance, after transplanting healthy gut flora, the drug resistance disappeared.

Oct. 9, 2021, a Mandarin article 16-year-old autism boy got improvement by transplanting fecal bacteria: in Jinan City, China, an autism boy do not want to communicate with people, after 6 times of transplantation of fecal bacteria, the boy begin to talk with his families. Doctor said that fecal bacteria can synthesize 5-hydroxylamine to mediate emotions of autism.

Melatonin is just good at optimizing the performance of second brain by optimizing Gut microbiota into the optimal state and which also proved the existence of a physiological basis of the treatment of TCM by focusing on the restoration of the Yin and Yang balance.

Optimal nutrient supply is the best medicines, which can prevent and cure diseases and ensure health. As long as we pay attention to diet and health, many diseases will not occur; in this purpose, melatonin will be the best helper. Even if we get sick, we can self-cure by daily diets at home without spending too much money, without need of going to see doctor or hospital.

Melatonin is able to cure Covid-19 patients and reduce the lesions

Jan. 03, 2022, Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

https://www.biorxiv.org/content/10.1101/2021.12.30.474561v1

Jan. 3, 2021, Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers

https://melatonin-research.net/index.php/MR/article/view/109

Nov 20, 2020, Melatonin is a potential treatment option for Covid-10 patients

https://health.clevelandclinic.org/can-melatonin-help-treat-covid-19/

Nov. 12, 2020, Melatonin Could Potentially Treat COVID-19

https://www.webmd.com/lung/news/20201111/melatonin-could-potentially-treat-covid-19

Nov. 23, 2020 ,Big data identifies melatonin as potential COVID-19 treatment

https://d4-pharma.com/big-data-identifies-melatonin-as-potential-covid-19-treatment/

Apr. 29,  2020,  Can melatonin reduce the severity of COVID-19 pandemic?

https://pubmed.ncbi.nlm.nih.gov/32347747/

Melatonin can avoid cytokines storm and sequelae of covid-19 damaging on brain and central nervous system.

April 8, 2019, article Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care reports that: Melatonin is a ubiquitous molecule with natural and powerful antioxidant proprieties and administration of exogenous melatonin is safe. Melatonin exerts anti-inflammatory effects mainly by inhibiting inflammasome activation. Melatonin exerts its antiapoptotic activities mainly by blocking caspase 3 cleavage and mPTP opening. “Oxygen radical diseases of neonatology” refers to the oxidative stress that has a leading role in the pathogenesis of neonatal morbidities and pathologic conditions.

Melatonin increases bone density to prevent osteoporosis

June 29, 2010, Melatonin Osteoporosis Prevention Study (MOPS):

Osteoporosis is one of the most common skeletal disorders. Today in the United States, 10 million individuals have osteoporosis and 34 million more have low bone mass or osteopenia, which places them at an increased risk of some day developing osteoporosis. Of the people affected by this problem, 68% are women.The current thinking on the development of osteoporosis is that the changes in bone turnover that occur with aging play a major factor.

Many modalities of treatment are used to prevent the bone loss and increased fracture risk associated with osteoporosis and osteopenia. Melatonin supplementation may be another treatment modality that lowers risk of hip fracture in perimenopausal women. Melatonin can remodel bone in animal models and in culture. Melatonin works through melatonin receptors to form osteoblasts from human mesenchymal stem cells and has been shown to inhibit osteoclast activity in rodents. Melatonin levels have been correlated with modulating bone markers; low nocturnal levels of melatonin correlate with in an increase in bone marker metabolism and osteoporosis. It is been shown that women who have worked night-shifts for greater than 20 years have increased risk for wrist and hip fractures. Night-shift workers have lower nocturnal melatonin levels than people who do not work the night-shift. The addition of exogenous melatonin suppresses bone marker metabolism. In human stem cells taken from bone marrow, melatonin increases the activity of bone-forming cells called osteoblasts. It is hypothesized that melatonin will improve bone health, menopausal quality of life and sleep compared to placebo in perimenopausal women.

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Melatonin stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells

Nov. 29, 2005, article Melatonin, immune function and aging reports that aging is associated with a decline in immune function. Innate, cellular and humoral immunity all exhibit increased deterioration with age with diminished phagocytic activity and impairment of superoxide generation. Melatonin stimulates the production of progenitor cells for granulocytes-macrophages. It also stimulates the production of NK cells and CD4+ cells and inhibits CD8+ cells. The production and release of various cytokines from NK cells and T-helper lymphocytes also are enhanced by melatonin.

May 19, 2020, Protective Role of Melatonin Against Postmenopausal Bone Loss via Enhancement of Citrate Secretion From Osteoblasts:

In general, we observed that melatonin promotes citrate secretion in osteoblasts and enhances matrix mineralization. In vivo, we also found that the effect of melatonin on the recovery of bone mass in postmenopausal mice is highly consistent with citrate levels in bone, and its mechanism of that action is primarily related to ZIP-1 expression. These results reveal the critical role of citrate in bone homeostasis and provide the research basis for the future clinical application of citrate in osteoporosis treatment. Of note, ZIP-1 is associated with zinc (Zn2 +) levels in osteoporosis; thus, whether zinc replenishment by dietary zinc supplementation would be of value in restoring the production of citrate in bone warrants further study.

Mar. 2019, Melatonin: Another avenue for treating osteoporosis?:

Melatonin is a signal molecule that modulates the biological circadian rhythms of vertebrates. Melatonin deficiency is thought to be associated with several disorders, including insomnia, cancer, and cardiovascular and neurodegenerative diseases. Accumulating evidence has also indicated that melatonin may be involved in the homeostasis of bone metabolism. Age-related reductions in melatonin are considered to be critical factors in bone loss and osteoporosis with aging. Thus, serum melatonin levels might serve as a biomarker for the early detection and prevention of osteoporosis. Compared to conventional antiosteoporosis medicines, which primarily inhibit bone loss, melatonin both suppresses bone loss and promotes new bone formation. Mechanistically, by activating melatonin receptor 2 (MT2), melatonin upregulates the gene expression of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP2), BMP6, osteocalcin, and osteoprotegerin to promote osteogenesis while inhibiting the receptor activator of NF-kB ligand (RANKL) pathway to suppress osteolysis. In view of the distinct actions of melatonin on bone metabolism, we hypothesize that melatonin may be a novel remedy for the prevention and clinical treatment of osteoporosis.

Aug. 28, 2019, Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis:

Melatonin can alleviate bone loss in RA-induced OP model mice, repair the trabecular microstructure, and promote bone formation. These effects may be related to reducing oxidation levels in vivo and vitro through the ERK/SMAD and NF-κB pathways.

Melatonin can antioxidize, detoxify, protect cardiovascular, immunization, brain or gastrointestinal

Apr. 2017, article Melatonin: Pharmacology, Functions and Therapeutic Benefits said that the physiological effects of melatonin are various and include detoxification of free radicals and antioxidant actions, bone formation and protection, reproduction, and cardiovascular, immune or body mass regulation. Also, protective and therapeutic effects of melatonin are reported, especially with regard to brain or gastrointestinal protection, psychiatric disorders, cardiovascular diseases and oncostatic effects. This review highlights the high number and diversity of major melatonin effects and opens important perspectives for measuring melatonin as a biomarker (biomarker of early identification of certain disorders and also biomarker of their follow-up) and using melatonin with clinical preventive and therapeutic applications in newborns, children and adults based on its physiological regulatory effects.

Feb. 2013; article Therapeutic applications of melatonin said that Melatonin contributes to the protection of the organism from carcinogenesis and neurodegenerative disorders. At a therapeutic level as well as in prevention, melatonin is used for the management of sleep disorders and jet lag, for the resynchronization of circadian rhythms in situations such as blindness and shift work, for its preventive action in the development of cancer, as additive therapy in cancer and as therapy for preventing the progression of Alzheimer’s disease and other neurodegenerative disorders.

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Melatonin can rescue chronic kidney failure

Jun. 27, 2017; article Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy reports that the stem cell senescence in patients with chronic kidney failure could be potentially rescued by the administration of melatonin, which grants this hormone a novel therapeutic role.

Melatonin can cure neurodegenerative diseases like Alzheimer’s disease

Sep. 8, 2010, Clinical Aspects of Melatonin Intervention in Alzheimer’s Disease Progression: Melatonin has a useful ad-on therapeutic role on age-associated neurodegenerative diseases like Alzheimer’s disease (AD) and cognitive impairment (MCI).

Melatonin promotes nerve regeneration

Dec. 7, 2018, Melatonin combined with chondroitin sulfate ABC promotes nerve regeneration after root-avulsion brachial plexus injury

The results showed that the Terzis grooming-test scores of the three groups that received treatment were better than those of the injury only group. Additionally, these three groups showed lower levels of C5–7 intramedullary peroxidase and malondialdehyde. Further, glial scar tissue in the C6 spinal segment was smaller and the number of motor neurons was greater. The endplate area of the biceps muscle was larger and the structure was clear. The latency of the compound potential of the myocutaneous nerve-biceps muscle was shorter. All these indexes were even greater in the melatonin + chondroitin sulfate ABC group than in the melatonin only or chondroitin sulfate ABC only groups. Thus, the results showed that melatonin combined with chondroitin sulfate ABC can promote nerve regeneration after nerve-root avulsion injury of the brachial plexus, which may be achieved by reducing oxidative damage and inflammatory reaction in the injury area and inhibiting glial scar formation.

April 19, 2018, Melatonin and sciatic nerve injury repair: a current perspective

Peripheral nerve injury is an important clinical problem that can exert hazardous effects on the health of patients. For this reason, there are more studies conducted on the regeneration of the peripheral nerves via the usage of the nerves belonging to various animals with different types of lesions, ages, and by using different methods of assessment with regular follow-up. Contrary to data obtained through experimentation and clinical observation, no ideal way of treatment was found to increase the regeneration of the peripheral nerves.

Finally, the effects of melatonin in the protection of peripheral nerves against trauma, especially the protection of sciatic nerve from pathological conditions, have come into attention in a wide group of scientists as there are beneficial effects of melatonin after surgery. While numerous studies indicate the melatonin’s protective effects on the pathologies of nerves, there are also studies reporting its toxic effects on peripheral nerves.

Melatonin is a widespread and crucial signaling molecule due to its features of free radical scavenging and anti-oxidation at both pharmacological and physiological conditions in vivo. In this context, although there are numerous studies elaborating the effects of melatonin in various tissues, its effects on peripheral nerves was documented in only a limited number of studies. The aim of this article was to perform a review of the knowledge in the literature on the subject of mostly beneficial or hazardous effects of melatonin on the repair of the damaged peripheral nerves.

Melatonin can inhibit the side effects of anti-psychotic drugs

Apr 25, 2012, Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects

Melatonin levels and melatonin circadian rhythm are significantly decreased in schizophrenic patients. The adjunctive use of melatonin in schizophrenia may augment the efficacy of antipsychotics through its anti-inflammatory and antioxidative effects. Further, melatonin would be expected to improve sleep disorders in schizophrenia and side effects of anti-psychotics, such as tardive dyskinesia, metaboilic syndrome and hypertension. It is proposed that melatonin also impacts on the tryptophan catabolic pathway via its effect on stress response and cortisol secretion, thereby impacting on cortex associated cognition, amygdala associated affect and striatal motivational processing. The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management. Melatonin is likely to have impacts on the metabolic side effects of anti-psychotics that contribute to subsequent decreases in life-expectancy.

May 14, 2013, Role of Melatonin in Schizophrenia

Schizophrenia is a chronic mental disease that disturbs several cognitive functions, such as memory, thought, perception and volition. Schizophrenia’s biological etiology is multifactorial and is still under investigation. Melatonin has been involved in schizophrenia since the first decades of the twentieth century. Research into melatonin regarding schizophrenia has followed two different approaches. The first approach is related to the use of melatonin as a biological marker. The second approach deals with the clinical applications of melatonin as a drug treatment. In this paper, both aspects of melatonin application are reviewed. Its clinical use in schizophrenia is emphasized.

Melatonin for Schizophrenia

Melatonin is a naturally occurring hormone in the body, produced by a gland in the brain (the pineal gland). It acts directly on sleep, regulating the sleep-wake cycle. An anti-oxidant 6 to 10 times better than vitamin E, melatonin is decreased in schizophrenia, particularly in chronic patients.

Likely Effectiveness: Likely to partially treat medication side effects, such as tardive dyskinesia, and helpful for insomnia, weight gain, and high blood pressure. Effective as an adjunct therapy to antipsychotics, since it does not decrease symptoms of schizophrenia on its own.

Effective Dosage: 0.5mg to 10mg per day as a supplement. It may be administered as capsules, tablets, liquids, or as transdermal patches. Oats, sweet corn, and rice are the best food sources of melatonin (although in significantly lower amounts than are taken in supplements).

Research: Quality experiments: “double-blind, placebo-controlled, crossover;” well reviewed. Some studies are less recent, but still relevant.

Risks:  No side effects reported at therapeutic doses.

Selected references

1) Anderson G, and Maes M. Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metab Brain Dis .2012;27: 113-119.

Melatonin has been implicated in the development and maintenance of schizophrenia. Reviewed in this paper, melatonin’s roles include anti-oxidant and anti-inflammatory effects, as well as changes in sleep, circadian rhythms, and side effects of antipsychotics (tardive dyskinesia and metabolic abnormalities). Melatonin levels are decreased in patients with schizophrenia, particularly at night; more than 80% of people with schizophrenia suffer from disturbed sleep. Melatonin also alleviates some side effects of antipsychotics, such as weight gain and increased blood pressure. For these reasons, melatonin is likely to be a positive adjunct therapy for people with schizophrenia.

2) Suresh Kumar PN, Andrade C, Bhakta SG, and Singh NM. Melatonin in schizophrenic outpatients with insomnia: a double-blind, placebo-controlled study. J  Clin Psychiatry.2007; 68:237-241.

Participants in this study were stable on an antipsychotic (Haldol) and had a chief complaint of insomnia. 20 patients received an average of 3.0mg/night melatonin while 20 others received placebos. By the end of the study (15 days), they reported longer, better sleep: fewer awakenings, no “hangover” effect, faster to fall asleep, improved mood, and improved daily functioning. Since insomnia is stressful and stress exacerbates symptoms of schizophrenia, reducing insomnia is clinically important.

3) Shamir E, Barak Y, Shalman I, Laudon M, et al. Melatonin treatment for tardive dyskinesia: a double-blind, placebo-controlled, crossover study. Arch Gen Psychiatry. 2001;58: 1049-1052.

Among people with schizophrenia who have over 20 to 25 years of exposure to certain antipsychotic drugs, almost 70% develop tardive dyskinesia (TD). The present study examined the efficacy of melatonin, in treating TD. The 16-week, well-designed (“double-blind, placebo-controlled, crossover”) trial for 22 patients with schizophrenia, found that 5.0mg of melatonin, twice a day, demonstrated that melatonin decreases TD. TD severity was assessed using standard testing (AIMS: Abnormal Involuntary Movement Scale). The worse the initial symptoms, the better the response to treatment.

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Melatonin is a potential treatment for Amyotrophic lateral sclerosis (ALS)

Nov. 2006, article Reduced oxidative damage in ALS by high-dose enteral melatonin treatment reports that Melatonin is an amphiphilic molecule with a unique spectrum of antioxidative effects not conveyed by classical antioxidants. In preparation of a possible future clinical trial, we explored the potential of melatonin as neuroprotective compound and antioxidant in: (1) cultured motoneuronal cells (NSC-34), (2) a genetic mouse model of ALS (SOD1(G93A)-transgenic mice), and (3) a group of 31 patients with sporadic ALS. We found that melatonin attenuates glutamate-induced cell death of cultured motoneurons. In SOD1(G93A)-transgenic mice, high-dose oral melatonin delayed disease progression and extended survival. In a clinical safety study, chronic high-dose (300 mg/day) rectal melatonin was well tolerated during an observation period of up to 2 yr. Importantly, circulating serum protein carbonyls, which provide a surrogate marker for oxidative stress, were elevated in ALS patients, but were normalized to control values by melatonin treatment. This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS.

Mar 26, 2013, article Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis reports that Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage. By screening a drug library, we found that melatonin, a pineal hormone, inhibited cytochrome c release in purified mitochondria and prevented cell death in cultured neurons. In this study, we evaluated whether melatonin would slow disease progression in SOD1(G93A) mice. We demonstrate that melatonin significantly delayed disease onset, neurological deterioration and mortality in ALS mice. ALS-associated ventral horn atrophy and motor neuron death were also inhibited by melatonin treatment.

Melatonin inhibited Rip2/caspase-1 pathway activation, blocked the release of mitochondrial cytochrome c, and reduced the overexpression and activation of caspase-3. Moreover, for the first time, we determined that disease progression was associated with the loss of both melatonin and the melatonin receptor 1A (MT1) in the spinal cord of ALS mice. These results demonstrate that melatonin is neuroprotective in transgenic ALS mice, and this protective effect is mediated through its effects on the caspase-mediated cell death pathway. Furthermore, our data suggest that melatonin and MT1 receptor loss may play a role in the pathological phenotype observed in ALS. The above observations indicate that melatonin and modulation of Rip2/caspase-1/cytochrome c or MT1 pathways may be promising therapeutic approaches for ALS.

Jany 29, 2021, article Melatonin Might Benefit ALS Patients, But More Research Needed reports that people with amyotrophic lateral sclerosis (ALS) who use melatonin have better survival outcomes and experience slower disease progression, a new analysis indicates.

The findings suggest that melatonin may be beneficial for people with ALS. However, because the analysis was not designed to find cause-and-effect relationships, further studies are needed, researchers said.

Results of the study, “Melatonin may slow disease progression in amyotrophic lateral sclerosis: Findings from the Pooled Resource Open‐Access ALS Clinic Trials database,” were published in Muscle & Nerve.

Melatonin is a hormone that is produced naturally by the brain in response to darkness; it helps to regulate sleep cycles. Treatment with melatonin supplements, which are available over-the-counter, is sometimes used to help people fall asleep.

Melatonin has biological effects apart from its effect on sleep, though many of these are poorly understood. Among its effects, melatonin is an antioxidant, which means it can help lessen a type of cellular damage called oxidative stress — an excessive production of toxic oxidative molecules — that has been implicated in the development and progression of ALS.

“Because oxidative stress is a contributing factor in the pathogenesis [development] of ALS, it is reasonable to hypothesize that melatonin may also prove to be beneficial for patients with this disease,” the researchers wrote. “The aim of this study was to investigate if melatonin use among patients with ALS was associated with slower disease progression and longer survival.”

The researchers analyzed data from the PRO-ACT database, which contains data from 23 ALS clinical trials. A total of 1,622 ALS patients were included; of these, 18 were consistently on melatonin in the respective clinical trial.

Melatonin users were significantly younger on average than non-users (52.2 vs. 58.3 years). They also had significantly higher forced vital capacity (FVC), a measurement of lung function, and were less likely to require ventilation. Other demographic and pre-treatment clinical factors were similar between users and non-users.

Of the 18 melatonin users, four (22.2%) died during the studies. Of the non-users, 1,360 (75.1%) died. Statistical analyses showed that the risk of death was significantly lower — by 76% — among the melatonin users.

Disease progression, as measured by a standardized ALS functional rating scale, was significantly slower among melatonin users than non-users. The decline in FVC also was significantly slower in users.

“This small retrospective large-database study suggests that melatonin may be beneficial for patients with ALS,” the researchers wrote.

Importantly, the design of this study makes it impossible to determine whether there is a cause-and-effect relationship between melatonin use and these improved outcomes.

“These findings do not imply causation [cause-and-effect] and simply represent associations between melatonin use and these selected positive outcomes of ALS,” the researchers wrote.

They added: “These results are solely intended to be hypothesis generating and no strong associations can be made between melatonin and ALS disease progression.”

The researchers noted the study has significant limitations, including the small number of melatonin users and the differences between users and non-users prior to treatment.

Additionally, due to the database used, the researchers were unable to account for some factors that are known to affect disease progression and survival in ALS patients (e.g., caregiver support and comorbid conditions).

“Regardless, given its low cost and favorable safety profile, further research of melatonin is warranted to investigate possible efficacy [in ALS],” the researchers concluded.

Reductionism guided Western medicine misleads medical studies going on wrong way

However, the most of those studies seem simply focusing on the improvement of sleep with ignored the key curative effect of radical improving digestion and thereby radically optimized the nutrition supply.

The sadness of Reductionism guided Western medicine cultures people to addict in paying attention to a micro matter in ignoring macro reality as that only can see a tree and ignore the forest without sense that optimized the nutrition supply is the key for curing any diseases.

For reducing the death and complication of the Covid-19 patients, the Melatonin should be added as key medication; while cabbage and potato of the promoter of health gut flora, must be added in the diet.

Melatonin will be the magic for curing the most of diseases by radically improving nutrition supply and which is the best treatment than that of any medication.

For reducing the death and complication of the Covid-19 patients, the Melatonin should be added as key medication; while cabbage and potato of the promoter of health gut flora, should be added in the diet.

I think of that the digestive system – Gut should be the plant that is producing everything of our body needs.

The perfect nutrition supply will play a therapeutic role for curing diseases; especially for those degenerative one; while the perfect nutrition supply will be able to avoid the occurrence of diseases to help people from disease free.

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3.4.4... Drug concept revolution: The Orthomolecular Medicine is best drug sources

The orthomolecular medicine of vitamins, minerals, amino acids, trace elements and fatty acids will be the best treatment for the most of diseases; the key is at the high concentration in blood, which needs intravenous infusion in use and megadose in g/kg body weight.

3.4.4.1... Vitamin C has multi-therapeutic effects that cover the most of diseases

The LD50 of Vitamin C is generally accepted to be 11900 milligrams (11.9 grams) /kg. The American Association of Poison Control Centers has reported zero deaths from vitamin C.

Oct. 30, 2020, article High-Dose Vitamin C (PDQ®)–Patient Version indicates that, “In a study of healthy volunteers and cancer patients, vitamin C was shown to be safe at doses up to 1.5 g/kg in patients who do not have kidney stones, other kidney diseases, or G6PD deficiency. Studies have also shown that vitamin C levels in the blood are higher when given by IV than when taken by mouth, and last for more than 4 hours.”

Article Vitamin C Saves Lives said that after Linus Pauling wrote his book on vitamin C in 1970, mortality from heart disease decreased 30-40% in the USA, from around 741,000 deaths per year to less than 500,000 deaths by 1986 according to U. S. Bureau of National Health Statistics 1986.

Feb. 2014, High-dose Intravenous Vitamin C as a Successful Treatment of Viral Infections: “Viral infections often lead to oxidative stress to the infected cells, and therefore, antioxidants are expected to suppress oxidative stress and work as antivirals or ‘drugs,’ improving inflammatory symptoms. Among these substances, the protective effect of ascorbic acid has been assumed due to its powerful scavenging and antioxidative property.”

“Vitamin C is also involved in enhancing several functions of the immune system. Cells of the immune system have one of the highest concentrations of vitamin C: white blood cells have an 80 times concentration of vitamin C in their cytoplasm, allowing them to create a vitamin C concentration surplus at the site of infection. Vitamin C can also enhance the production of interferon, which helps prevent cells from being infected by a virus, stimulate the activity of antibodies and cytokines, and in mega-doses, play a role in mitochondrial energy production. It can enhance the ability of specialized immune cells to ingest bacteria.”

‘In addition to this general neutralizing effect, vitamin C interferes with the assembly of viral RNA and DNA. In a recent study (2012), in vitro experiments showed ascorbate’s ability to kill isolated influenza viruses, as well as viruses from normal human bronchial epithelial cells. There was a dosedependent effect—a concentration of 2.5mM was able to eliminate 90% of the virus present and a 20 mM solution completely stopped the replication of the virus. The antiviral effect of ascorbate is greater when introduced in the early stages of infection.”

High Dose Vitamin C and Influenza: A Case Report; From the Journal of Molecular Biology, 2019.

A 25-year-old man contracted flu and went from approximately 170 pounds down to 155 pounds to be cured by Intravenous Vitamin C (IVC) therapy, which consisted of 1,000 cc of lactated Ringer’s solution containing 50 grams of sodium ascorbate, a pH-neutral form of vitamin C. This was infused over about one and a half hour in a total of 3 infusions over 3 days. All of the infusions were clinically uneventful and without discernible side effects. Actually, the morning following the first IVC, the patient noted that his body strength had improved dramatically.

Google will find many health benefits of Vitamin C. The key is at use in Megadose.

 

                 

Role in immunity of Vitamin C; Linus Pauling Institute, Oregon State University

https://lpi.oregonstate.edu/mic/vitamins/vitamin-C#role-in-immunity

Vitamin C affects several components of the human immune system in vitro; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Specific measures of functions stimulated by vitamin C include cellular motility, chemotaxis, and phagocytosis.

Vitamin C and Infections; From the Nutrients. 2017 Apr; 9(4) online 2017 Mar 29

Vitamin C deficiency was associated with pneumonia. A number of studies investigated the effects of vitamin C on diverse infections. A total of 148 animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. 

High-dose Intravenous Vitamin C as a Successful Treatment of Viral Infections.

https://riordanclinic.org/2014/02/high-dose-intravenous-vitamin-c-as-a-successful-treatment-of-viral-infections/

High dose (7.5 to 50 grams) intravenous vitamin C (IVC) therapy may have a positive effect on disease duration and may reduce viral antibody levels. Several mechanisms for vitamin C’s antiviral effect are antioxidant property of vitamin C promotes a reducing environment in the bloodstream and tissues, enhancing the body’s response to oxidative stress from inflammation, thereby helping to fight microbes and viruses that propagate in stressful conditions.

Vitamin C is also involved in enhancing several functions of the immune system. Cells of the immune system have one of the highest concentrations of vitamin C: white blood cells have an 80 times concentration of vitamin C in their cytoplasm, allowing them to create a vitamin C concentration surplus at the site of infection.

Vitamin C can also enhance the production of interferon, which helps prevent cells from being infected by a virus, stimulate the activity of antibodies and cytokines, and in mega-doses, play a role in mitochondrial energy production. It can enhance the ability of specialized immune cells to ingest bacteria.

2019 Mar. 27, 2019, Vitamin C Can Shorten the Length of Stay in the ICU.

A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8%. In six trials, orally administered vitamin C in doses of 1?3 g/day reduced the length of ICU stay by 8.6% . In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2%.

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients

Vitamin C protects important organ systems (cardiovascular, neurologic and renal systems) during inflammation and oxidative stress. It also influences coagulation and inflammation; its application might prevent organ damage.

Sep. 1, 2013, article Vitamin C in Disease Prevention and Cure: An Overview said that Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections.

April 2002; article Vitamin C function and status in chronic disease reports that Vitamin C is an essential dietary nutrient required as a co-factor for many enzymes, and humans are among the few animals that lack the ability to synthesize the compound from glucose. There is great interest in the clinical roles of vitamin C because of evidence that oxidative damage is a root cause of, or at least associated with, many diseases. Population studies show that individuals with high intakes of vitamin C have lower risk of a number of chronic diseases, including heart disease, cancer, eye diseases, and neurodegenerative conditions.

Aug. 10, 2020, article 'Unusual' IV High-Dose Vitamin C Success Story in COVID-19 reports that a 74-year-old white woman presents to an emergency department in Flint, Michigan, after suffering with low-grade fever, dry cough, and shortness of breath for the previous 2 days. Then confirmed with the infection of SARS-CoV-2.

Clinicians start treatment with oral hydroxychloroquine 400 mg once and then 200 mg twice a day, along with intravenous azithromycin 500 mg once a day, zinc sulfate 220 mg three times a day, and oral vitamin C 1 g twice a day.

By day 6, given her rapid deterioration, the patient is intubated on an emergent basis and started on pressure-regulated volume-controlled mechanical ventilation.

On day 7, the second day of mechanical ventilation, at the request of the family when the patient develops ARDS, she is started on a continuous intravenous infusion of high-dose vita-min C (11 g /24 hours). Two days later, her clinical condition gradually begins to improve, and the clinicians discontinue supportive treatment with norepinephrine.

Two days later, her clinical condition gradually improved. On day 10, the fifth day of mechanical ventilation, another chest x-ray shows that both the pneumonia and interstitial edema have improved considerably. Her breathing status continues to improve over days 11-15. On day 16, she shows significant recovery. On day 16 of her illness, she still tests positive and is in stable condition with an additional 14 days of quarantine.

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3.4.4.2... Vitamin B3

Aug. 28, 2012, article Vitamin B3 May Help Kill Superbugs said that “Nicotinamide, commonly known as vitamin B3, may help the innate immune system kill antibiotic-resistant staph bacteria, the so-called "superbugs". In lab work done with mice and human blood, researchers found high doses of the vitamin increased the ability of immune cells to kill the bacteria by 1,000 times.”

I Google found that the LD 50 vitamin B3 is 4.5 grams/kilo. This is equivalent to 225 grams for a 50 kg people or approximately 100 times as much as is normally recommended.

3.4.4.3... My personally tested the flush of the side effect of Vitamin B3

It said that high doses of Niacin has side effect of flush. In order to verify its safety tolerance, my personally tested the flush of taking B3; Jan. 25, 2020, I bought a bottle of B-3 (Niacin) and took 500mg x 2 in one time.

12:10, I orally took 500mg x 2 with water.

12:27, I started to feel a slight hot and itching...

12:38, face, forehead, back of neck, outside of arms, were obviously hot, itchy...

12:48, my thighs were hot and itching. There was a desire to scratch the outside of the arms.

12:50, I start to scratch the back, both sides of the belly. My thighs were obvious hot, itchy, and swollen.

13:05, the hot and itch begin to subside.

14:05, I still have the feeling of hot and itchy.

15:39, the skin of thighs and calves seems to be in slightly hot water.

17:19, the skin of thighs and calves still felt hot, and the face was hot.

19:01, only the face was hot, no itching all over the body.

The overall feeling was warm, itchy and was bearable.

Thanks B-3.

Thanks Dr. Abram Hoffer.

Please see my Jan. 23, 2020 article Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for 2019 new coronavirus and other acute and chronic diseases.

Vitamin B3 may help the most of medication exert the therapeutic role by improving blood circulation to help drug delivery throughout the body.

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3.4.4.4... Vitamin D

Jun, 2015, Vitamin D for influenza

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

A colleague of mine and I have introduced vitamin D at doses that have achieved greater than 100 nmol/L in most of our patients for the past number of years, and we now see very few patients in our clinics with the flu or influenzalike illness. In those patients who do have influenza, we have treated them with the vitamin D hammer, as coined by my colleague. This is a 1-time 50 000 IU dose of vitamin D3 or 10 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.8 We urgently need a study of this intervention. The cost of vitamin D is about a penny for 1000 IU, so this treatment costs less than a dollar.

Vitamin D, Essential Minerals, and Toxic Elements: Exploring Interactions between Nutrients and Toxicants in Clinical Medicine.

https://www.ncbi.nlm.nih.gov/pubmed/26347061

In clinical medicine, increasing attention is being directed towards the important areas of nutritional biochemistry and toxicant bioaccumulation as they relate to human health and chronic disease. Optimal nutritional status, including healthy levels of vitamin D and essential minerals, is requisite for proper physiological function; conversely, accrual of toxic elements has the potential to impair normal physiology. It is evident that vitamin D intake can facilitate the absorption and assimilation of essential inorganic elements (such as calcium, magnesium, copper, zinc, iron, and selenium) but also the uptake of toxic elements (such as lead, arsenic, aluminum, cobalt, and strontium).

Furthermore, sufficiency of essential minerals appears to resist the uptake of toxic metals. This paper explores the literature to determine a suitable clinical approach with regard to vitamin D and essential mineral intake to achieve optimal biological function and to avoid harm in order to prevent and overcome illness. It appears preferable to secure essential mineral status in conjunction with adequate vitamin D, as intake of vitamin D in the absence of mineral sufficiency may result in facilitation of toxic element absorption with potential adverse clinical outcomes.

Note: As of the studies and clinical practices, here, I would like to infer that the effective use of orthomolecular medicine, such as, the vitamins C, the megadoses and intravenous infusion is the key. The megadoses should be up to the level of 1 gram / kg of body weight. The oral taking may be the reason that megadose of vitamin C is less effective, due to the limited absorption capacity of the human body.

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3.4.5... Honey has multi-therapeutic effects that cover the most of diseases

The treatment of Covid-19 infections:

Nov. 6, 2020, study report Efficacy of honey and Nigella sativa against COVID-19: HNS-COVID-PK Trial said that, Of 313 patients, 210 moderate and 103 severe underwent randomization. Among these 107 were assigned to HNS (Honey and Nigella sativa) whereas 103 to placebo for moderate cases. For severe cases, 50 were given HNS and 53 placebos. HNS resulted in symptoms alleviation by 3 and 7 days in moderate and severe disease. HNS also cleared the virus 4 days earlier in moderate and severe cases. HNS further led to a better clinical score on day 6 with normal activities in 63.6% and 28% patients. A reduction in 30-day mortality among severe patients was shown with HNS. No HNS-related adverse effects were observed. HNS improved symptoms, viral clearance and mortality in COVID-19 patients.

The multi-targeted therapeutic effects:

2020 Dec 21, study report Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises, Honey has ability to attenuate acute inflammation through enhancing immune response. Studies prove its potential healing capability against numerous chronic diseases/conditions, including pulmonary disorders, cardiac disorders, diabetes, hypertension, autophagy dysfunction, bacterial, and fungal infections. More importantly, honey has proved its virucidal effect on several enveloped viruses such as HIV, influenza virus, herpes simplex, and varicella-zoster virus.

April, 2017, article Honey and Health: A Review of Recent Clinical Research said that Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment.

Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, throat infections, tuberculosis, thirst, hiccups, fatigue, dizziness, hepatitis, constipation, worm infestation, piles, eczema, healing of ulcers, and wounds and used as a nutritious supplement. The ingredients of honey have been reported to exert antioxidant, antimicrobial, anti-inflammatory, antiproliferative, anticancer, and antimetastatic effects. Many evidences suggest the use of honey in the control and treatment of wounds, diabetes mellitus, cancer, asthma, and also cardiovascular, neurological, and gastrointestinal diseases. Honey has a potential therapeutic role in the treatment of disease by phytochemical, anti-inflammatory, antimicrobial, and antioxidant properties. Flavonoids and polyphenols, which act as antioxidants, are two main bioactive molecules present in honey.

According to modern scientific literature, honey may be useful and has protective effects for the treatment of various disease conditions such as diabetes mellitus, respiratory, gastrointestinal, cardiovascular, and nervous systems, even it is useful in cancer treatment because many types of antioxidant are present in honey.

In conclusion, honey could be considered as a natural therapeutic agent for various medicinal purposes. Sufficient evidence exists recommending the use of honey in the management of disease conditions. Based on these facts, the use of honey in clinical wards is highly recommended.

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3.4.6... Suggested combo for curing Covid-19 by handy available diets and medicinals

For the concern of being able to uproot pandemic Covid-19 globally, the used medicinals must be cheaper handy available for any people at any corner world widely.

As of current understanding, the vinegar is the only diet with confirmed function of inactivating SARS-CoV-2 and can be safe in-taking; while have many therapeutic effects and health benefits on human body. Honey has many therapeutic effects as medicinal combo and health benefits on human body; and vitamin C is immune booster, and Aloe Vera has anti-inflammatory effect and can promotes bowel movement to avoid constipation. Such a combo can immediately show curative effect after being taken shortly.

Views above therapeutic effects and the concern of handy available for any people; I infer that the combination of 5% vinegar in 10 - 20 ml + honey in 20 ml + melatonin in 5 – 10 mg + vitamin C 3g + Aloe Vera (Leaf or juice) + OTC tablets of TCM (Not necessary, the available will be the best) in daily 3 – 4 times will be able to quickly cure Covid-19 patients without complications and cure covid-19 survivors who are in complications torturing.

I suggest some OTC tablets of TCM, LianhuaQingwenCapsule; FuFangDanShenPian; HuangQiPian; CiWuJiaPian; HeShouWuPian, LiuWeiDiHuangWan; Lianhua Qingwen Capsules, and so on.

Above combo will be a cure for infectious and chronic diseaes.

The resistance for the use of above safe medication will come from those medical experts and officials in Western medicine. They have rejected use of experience based medication, especially, the TCM; while by the double blind clinic trial; they proved WHO suggested clinically effective synthetic drugs as ineffective.

Thus, by scientific way, those scientific medical experts and officials in Western medicine have successfully blocked the most of the way for the treatment of Covid-19 patients; actually, from kind intention; they acted as indirect killer.

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3.4.7... Some ideas for quickly returning pre-pandemic life

3.4.7.1...The treatment of Covid-19 by honey and vinegar

The Covid infection is syndrome in ever developing, the full cover therapeutic effect of vinegar is able to cure the multi-lesions as that of shotgun is able to hit multi-targets by electronegativities of oxygen atoms in vinegar molecular.

By drinking 2 to 4 dose of water diluting honey and 5% vinegar in 20 milliliters /50kg or 2 x 500mg vinegar capsules /50kg will be able to cure Covid patients in any conditions in daily 3 times.

Above medication will also be able to cure the long COVID sufferers and potential existing diseases; especially, those chronic degenerative diseases by a little bit more doses.

It is better to add Melatonin in 3 mg.

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3.4.7.2... The prevention of Covid-19 by vinegar and hypochlorite

Develop portable sprayer with flavors mixing Vinegar or/and hypochlorite for daily use; by ensured self-protection, people will be able to engage in social activities under pandemic to return pre-pandemic life immediately without the need of Covid test and vaccination. Importantly, which will be able to cure Covid infected patients; then no one dedicates own body as host for virus replication; the pandemic will be end naturally.

By lungs absorbing into blood, the full cover therapeutic effect of vinegar and hypochlorite will make systemic therapy; thereby curing Covid-19 infections and potential existing diseases; especially, those chronic degenerative diseases.

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3.4.7.3... Confirm the safety of hypochlorite in long term use by body test of disinfection operators

Since Mar. 12, 2020, I email conducted a meat foods plant DC Foods Waterloo in zero infection.

After my first email, the plant set several people for daily disinfection with sprayer to spray disinfectant on the area of people just touched. Due to the lunchroom is small, for keeping social distance, employees have to take lunch in several group; the repeated disinfect made the lunch room is always filled with strong smell of disinfectant in the air.

I judged that it is the daily disinfection produced disinfectant mixing air to be inhaled and timely killed potential virus in the eyes and respiratory tract of employees; because that mask wearing or environment disinfecting in plant cannot help to avoid employees to be cluster infected in home and which is the main cause of the Covid-19 infections.

Now, the disinfection operators have been working on the job for nearly three years; therefore they have inhaled times more disinfectants mixed air than others have, thus, they have unexpectedly created biological samples for researching on the long term hazards of hypochlorous acid.

We may have their body checked in the Health Physiological Indicators as the proof of long term hazards of hypochlorous acid.

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3.4.7.4... Government must force the study in the cheaper approaches

Government must fund the studies in cheaper medications that people can self-help in disease treatment and prevention to reduce the reliance on public healthcare by which solving the dilemma in healthcare of Canada.

But; the key is at that government must force the studies in profitless medications; otherwise the medical experts will waste fund in the genetic studies, because of their brain has been distorted in such a psychotic way.

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3.5... Develop new drug based on brand new drug concept

I have prepared hundreds pound of natural medicinal that is able to cure Alzheimer's disease, I’d like to cooperate with some organization to develop some drug for curing Alzheimer's disease and related mental disorders.

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3.6... The inhalable antiviral volatile may be the only hope for saving livestock industry

Nov. 28, 2020, a Mandarin report Highly pathogenic avian influenza virus strain detected in Norway and South Korea: Norway and South Korea have discovered highly pathogenic H5 subtype avian influenza in wild birds and poultry. Denmark, Sweden, the United Kingdom, Germany, France, Poland, and Belgium have also confirmed cases, indicating that an outbreak of avian influenza is occurring in Europe. South Korea is in urgently culling their ducks.

Nov. 6, 2020, a repot Coronavirus: Denmark shaken by cull of millions of mink: Last week, Denmark decided to cull all its mink - up to 17 million animals - because of the spread of coronavirus. Danish authorities worry that a mutated form of coronavirus found in mink could potentially hamper the effectiveness of a future vaccine. Denmark is not the first country to report outbreaks; Spain, Sweden, Italy, and the US have all been affected, as has the Netherlands, where mink farming will be outlawed by spring next year.

The report said that Mr. Martin From is a third-generation fur farmer, and after 60 years of the family business, the cull has devastated him. He desperately sighed "This is the end of our business with mink farming; we won't be able to start up again". Mr. Martin From is not alone. Farmers have appeared on Danish TV in tears.

Jan. 16, 2021, a Mandarin article Seven animals have infected with Covid-19, just vaccinating humans is not enough reports that after tigers, lions, mink, snow leopards, dogs and cats were confirmed to be infected, gorilla is the seventh animal to be naturally infected with the virus. Laboratory studies have shown that dogs, cats, tigers, hamsters, monkeys, ferrets, civet cats and genetically engineered mice, even squirrels, sheep and sperm whales may be infected by the novel croronavirus.