hedonic eating dopaminergic brain circuit 享樂性進食

“享樂性進食（Hedonic eating）被定義為出於食物的可口性而非生理需求的攝食行為。然而，對可口食物攝入的神經調控機製仍知之甚少。我們發現，享樂性進食受一條來自peri–...的神經通路控製。”

 the Chinese translation of 超越享樂性進食

一種多巴胺能腦回路驅動小鼠的食物攝取
Dana M. Small 著
發表於《科學》（Science）
2025年3月27日
第387卷，第6741期，第1353-1354頁
DOI: 10.1126/science.adw3646

---

摘要
將能量以脂肪形式儲存的能力，使動物能夠為未來確保能量儲備。在這種背景下，超越飽腹感的進食是一種有益的、適應性的行為。然而，在許多人類群體中，這種適應性行為因高能量密度食物的輕易獲取而變得不再適應，導致肥胖率居高不下。其中一種行為，稱為“激活行為”（invigoration），會導致對可口食物的攝入速度、持續時間及攝入量的增加。然而，這種行為背後的神經機製尚不清楚。

在本期第1376頁，Zhu等人報道了一個驅動小鼠“進食激活”行為的腦回路。該回路起始於藍斑周圍區域（periLC）的神經元，並導致伏隔核中的多巴胺釋放。該發現揭示了一個神經靶點，未來通過對其進行治療性調控，可能有望通過阻止激活行為來改變食物攝入。 "Beyond hedonic eating A dopaminergic brain circuit drives food consumption in mice Dana M. Small Authors Info & Affiliations Science 27 Mar 2025 Vol 387, Issue 6741 pp. 1353-1354 DOI: 10.1126/science.adw3646 1,063 Metrics Total Downloads 1,063 Last 6 Months 1,063 Last 12 Months 1,063 Abstract References and Notes eLetters (0) Information & Authors Metrics & Citations Check Access References Share Abstract The capacity to store energy as fat enables animals to ensure energy reserves for the future. In this context, eating beyond satiety (fullness) is a beneficial, adaptive behavior. However, in many human populations, this adaptive behavior is made maladaptive by readily available, energy-dense sources of food, resulting in high rates of obesity. One such behavior, called invigoration, causes an increase in speed, duration, and intake of a palatable food (1). The neural mechanisms underlying this behavior are not yet clear. On page 1376 of this issue, Zhu et al. (2) report a brain circuit that drives feeding invigoration in mice. This circuit begins with neurons in the area around the locus coeruleus (periLC) and results in dopamine release in the nucleus accumbens. The finding provides a neural target, the therapeutic modulation of which might enable changes to food intake by preventing invigoration."