俠骨柔情
浪跡天涯，追月尋夢
正文
8. 中山大學基礎醫學院院長黎孟楓教授
中山大學副校長，長江學者特聘教授
中國醫學科學院病毒所博士
美國皮茨堡大學博士後
美國皮茨堡大學助教授
代表文章：
（1). Frank Riedel, Karl Götte, Mengfeng Li, Karl Hörmann, *Jennifer Rubin Grandis (corresponding author). Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo. International Journal of Oncology. 2003, 23(3): 577-83.
（2). Hideo Niwa, Abbey Wentzel, Mengfeng Li, William L. Gooding, Vivian Wai Yan Lui, *Jennifer Rubin Grandis (corresponding author). Antitumor Effects of EGFR Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck. Clinical Cancer Research, 2003, 9:5028–5035.
（3). Caisheng Ye, Chong Feng, Xiaoning Liu, Shenming Wang, Yongjie Lin and *Mengfeng Li (corresponding author). sFlt-1 gene therapy of follicular thyroid carcinoma. Endocrinology, 2004, 145 (2): 817-822.
（4). Chong Feng, Caisheng Ye, Xiaoning Liu, Hong Ma and *Mengfeng Li (corresponding author). b4 integrin is involved in statin-induced endothelial cell death, Biochem Biophys Res Commun. 2004, 323(3): 858-64.
（5). Zhuo Chen, Xin Zhang, Mengfeng Li, Zhiqiang Wang, Harry Samuel Wieand, Jennifer Rubin Grandis, *Dong Moo Shin (corresponding author). Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004, 10(17): 5930-9.
（6). 葉財盛、王深明、林勇傑、劉曉寧、*黎孟楓（通訊作者），轉內皮抑素基因通過抑製血管生成抑製甲狀腺濾泡狀癌生長.中國實用外科雜誌，2003，23（3）：153-156.
（7). 葉財盛、王深明、林勇傑、鄭朝旭、劉曉寧、*黎孟楓（通訊作者），甲狀腺濾泡狀癌抗血管生成治療的實驗研究，中國實用外科雜誌，2004, 24 (11): 688-690.
9. 中國科學院北京基因組研究所新所長吳仲義教授
加拿大 British Columbia大學 群體遺傳學專業博士
美國Wisconsin大學Madison分校遺傳學實驗室博士後
美國芝加哥大學生態學與進化係教授、係主任，
台灣中央研究院院士
代表文章：
(1). Ting, C.-T., S.-C. Tsaur, M.-L. Wu and C.-I Wu, 1998 A rapidly evolving homeobox at the site of a hybrid sterility gene. Science 282: 1501-1504.
(2). Fay, J. C. and C.-I Wu, 1999 A human population bottleneck is not incompatible with the discordance between patterns of mitochondrial vs. nuclear DNA variation. Molec. Biol. Evol. 16:1003 - 1006.
(3). Wyckoff, G. J., W. Wang and C.-I Wu, 2000 Rapid evolution of male reproductive genes in the descent of man. Nature 403: 304 - 309.
(4). Sawamura, K., A. W. Davis and C.-I Wu, 2000 Genetic analysis by means of introgression into Drosophila melanogaster. Proc. Natl. Acad. Sci. 97:2652-2655.
(5). Wang, H-Y., H. Tang, C. K. Shen and C.-I Wu 2003 Rapidly evolving genes in human –
I. The glycophorins and their possible role in evading malaria parasites. Mol. Biol. Evol. 20:1795-1804.
Greenberg, A. J., J. R. Moran, J. A. Coyne, and Chung-I Wu 2003 Ecological adaptation during incipient speciation as revealed by precise gene replacement. Science 302: 1754-1757.
(6). Lu, J., W.-H. Li and C.-I Wu. 2003 Chromosomal speciation and gene flow. Science 302:988c.
Wu, C.-I, S. Shi and Y. Zhang 2004 A case for conservation. Nature 428:213-214. (A commentary in a supplementary issue).
(7). He, J et al. (51 authors) 2004. Molecuar evolution of the SARS-conronavirus during the course of SARS-epidemic in China. Science 303: 1666-1669 (C.-I Wu is a communicating author for the data analysis section).
(8). Sun, S, C. Ting, and C.-I Wu 2004 The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science 305: 81-83.
(9). Song, H.-D. et al. C.-I Wu and G.-P. Zhao 2005 Cross-host evolution of SARS coronavirus in palm civet and human. Proc. Natl. Acad. Sci. 102: 2430-2435
(10). Lu J, Tang T, Tang H, Huang J, Shi S, Wu C-I. 2006 The accumulation of deleterious mutations in rice genomes: a hypothesis on the cost of domestication. Trends in Genetics 22：126-131.
10. 清華大學生命科學與醫學院副院長施一公教授
The Johns Hopkins 大學生物物理學博士
紐約斯隆/凱特林癌症研究中心結構生物學實驗室博士後
普林斯頓大學Warner-Lambert/Parke-Davis終身教授
美國休斯醫學研究所研究員
代表文章：
(1). Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A.Cell. 2008 Apr 4;133(1):154-63.
(2). Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y. Structure of a site-2 protease family intramembrane metalloprotease.Science. 2007 Dec 7;318(5856):1608-12.
(3). Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.Nature. 2008 Mar 6;452(7183):56-61.
(4). Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y.Structure of a site-2 protease family intramembrane metalloprotease. Science. 2007 Dec 7;318(5856):1608-12.
(5). Yan N, Shi Y. Allosteric activation of a bacterial stress sensor. Cell. 2007 Nov 2;131(3):441-3.
(6). Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue, and Yigong Shi (2005). Structure of the CED-4/CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.Nature 437, 831–837.
(7). Stefan J. Riedl, Wenyu Li, Yang Chao, Robert Schwarzenbacher, and Yigong Shi (2005). Structure of the apoptotic protease activating factor 1 (Apaf-1) bound to ADP. Nature 434, 926–933.
(8). Nieng Yan, Lichuan Gu, David Kokel, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi (2004). Structural, Biochemical and Functional Analyses of CED-9 Recognition by the Pro-apoptotic Proteins EGL-1 and CED-4. Mol. Cell 15, 999–1006.
(9). Eric N. Shiozaki, Jijie Chai, Daniel J. Rigotti, Stefan J. Riedl, Pingwei Li, Srinivasa M. Srinivasula, Emad S. Alnemri, Robert Fairman, and Yigong Shi (2003). Mechanism of XIAP-mediated Inhibition of Caspase-9. Mol.Cell 11, 519-527.
(10). Jijie Chai Qi Wu, Eric Shiozaki, Srinivasa M. Srinivasula, Emad S. Alnemri, and Yigong Shi (2001). Crystal Structure of a Caspase Zymogen: Mechanisms of Activation and Substrate Binding. Cell 107, 399-407.
(11). Jijie Chai, Eric Shiozaki, Srinivasa M. Srinivasula, Qi Wu, Pinaki Datta, Emad S. Alnemri, and Yigong Shi (2001). Structural Basis of Caspase-7 Inhibition by XIAP. Cell 104, 769-780.
(12). Geng Wu, Jijie Chai, Tomeka Suber, Jia-Wei Wu, Chunying Du, Xiaodong Wang, and Yigong Shi (2000). Structural Basis of IAP Recognition by Smac/DIABLO. Nature408, 1008-1012.
(13). Jijie Chai, Chunying Du, Jia-Wei Wu, Saw Kyin, Xiaodong Wang, and Yigong Shi (2000). Structural and Biochemical Basis of Apoptotic Activation by Smac/DIABLO. Nature 406, 855-862.
(14). Hongxu Qin, Srinivasa M. Srinivasula, Geng Wu, Emad S. Alnemri, Yigong Shi (1999). Structural Basis of Procaspase-9 Recruitment by the Apoptotic Protease Activating Factor 1. Nature 399, 549-557.
11. 清華大學醫學院首屆院長吳階平院士
中國泌尿外科的先驅者之一， 2001 年受聘為清華大學醫學院首屆院長。吳階平院士曾任第八、九屆全國人大常委會副委員長。是中國科學院院士，中國工程院院士，第三世界科學院院士，美國醫師學院榮譽院士，比利時皇家醫學科學院院士，英國愛丁堡皇家外科醫師學院名譽院士，香港皇家外科醫師學院院士；中國科學技術協會名譽主席，中華醫學會名譽會長，中國醫學科學院名譽院長，中國協和醫科大學名譽校長，首都醫科大學終身名譽校長，南京大學醫學院名譽院長，和全國著名大學、學院、研究機構等二十餘家單位的名譽校長、名譽教授，以及國外著名大學、學院的榮譽院士或榮譽博士。
吳階平院士長期從事泌尿外科的臨床治療和科研工作，是中國泌尿外科的先驅者之一，在腎結核對側腎積水和腎上腺髓質增生研究中有獨創性見解。 1957 年首創用輸精管結紮並用精囊灌注術，增強了避孕效果，是我國男性節育技術的奠基人。 50 年代，首先提出的腎結核對側腎積水的概念，被國內外公認為“在臨床上有極重大的意義”，並率先利用回盲腸行膀胱擴大術治療膀胱攣縮取得成功，到 70 至 80 年代國外才作為最新方法介紹給公眾。 60 年代設計了特殊的導管改進前列腺增生的手術，使手術出血量大為減少，手術時間縮短，被稱為“吳氏導管”。 1977 年提出的“腎上腺髓質增生”是一個獨立的疾病，被收進 1979 年《美國泌尿外科年鑒》。 1995 年“吳階平泌尿外科醫學基金會”在北京成立。
12. 複旦大學發育生物和分子醫學研究所所長許田教授
耶魯大學遺傳學博士
耶魯大學遺傳學博士後
美國休斯醫學研究所研究員
耶魯大學醫學院遺傳係教授，副係主任
代表性文章：
（1). Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T. (2007). Tumor Suppressor CYLD Regulates JNK Induced Cell Death in Drosophila. Dev Cell 13:446-454.
(2). Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. (2005). Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice. Cell 122(3):473-483.
(3). Yang XL, Yu KP, Hao YW, Li D-M, Stewart R, Insogna KL, Xu T. (2004). LATS1 tumor suppressor affects cytokinesis by inhibiting LIMK1. Nature Cell Biology 6:609-617.
(4). Pagliarini, R.A., and Xu, T. (2003). A genetic screen in Drosophila for metastatic behavior. Science, 302(5648):1227-31.
(5). Potter CJ, Pedraza LG, Xu T. (2002). Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol., 4: 658-665.
(6). Zhang S, Xu L, Lee J, Xu T. (2002). Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell, 108: 45-56.
(7). Potter, C. J., Huang, H. and Xu, T. (2001). Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell, 105:357-368.
(8). Tao, W., Zhang, S., Turenchalk, G.S., Stewart, R.A., Chang, W., St. John, M.A.R., and Xu, T. (1999). Human homolog of the Drosophila melanogaster lats tumor suppressor modulates CDC2 activity. Nature Genetics, 21:177-181.
(9). St. John, M.A.R., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., A.F. Parlow, McGrath, J., and Xu, T. (1999). Mice deficient of Lats1 develop soft tissue sarcomas, ovarian tumors and pituitary dysfunction. Nature Genetics, 21:182-186.
(10). Qi, H., Rand, M., Wu, X., Sestan, N., Wang, W., Rakic, P., Xu, T., and Artavanis-Tsakonas, S. (1999). Processing of the Notch ligand Delta by the Metalloprotease Kuzbanian. Science, 283:91-94.
13. 北京生命科學研究所鄧興旺共同所長
加州大學伯克萊分校生物學博士
北大耶魯植物遺傳學聯合研究中心主任
耶魯大學計算生物學與生物信息學講座教授
(1). Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM & Deng XW.
Coordinated regulation of Arabidopsis thaliana development by light and gibberellins.Nature2008 Jan 24; 451(475-479).
(2). Li L, Wang X, Sasidharan R., Stolc V, Deng W, He H, Korbel J, Chen X, Tongprasit W, Ronald P, Chen R, Gerstein M, Deng XW. Global Identification and Characterization of Transcriptionally Active Regions in the Rice Genome
PLoS ONE.2007; 2(3): e294。
（3）. Li L, Wang X, Stolc V, Li X, Zhang D, Su N, Tongprasit W, Li S, Cheng Z, Wang J, Deng XW. Genome-wide transcription analyses in rice using tiling microarrays.Nature Genetics.2006 Jan;38: 124 – 129.
(4).Rubio V, Deng XW. Phytunes: phosphorylation status and phytochrome-mediated signaling. Cell. 2005 Feb 11;120(3):290-2.
(5). Yanagawa Y, Sullivan JA, Komatsu S, Gusmaroli G, Suzuki G, Yin J, Ishibashi T, Saijo Y, Rubio V, Kimura S, Wang J, Deng XW. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 2004 Sep;18: 2172-2181.
(6). Saijo Y, Sullivan JA, Wang H, Yang J, Shen Y, Rubio V, Ma L, Hoecker U, Deng XW. The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. Genes Dev. 2003 Nov 1;17(21):2642-7.
(7). Suzuki G, Yanagawa Y, Kwok SF, Matsui M, Deng XW. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 2002 Mar 1;16(5):554-9.
(8).Wang H, Ma LG, Li JM, Zhao HY, Deng XW. Direct Interaction of Arabidopsis Cryptochromes with COP1 in Mediation of Photomorphogenic Development. Science 2001 Oct 5;294(5540):154-8.
14. 複旦大學生物醫學研究院院長賀林
英國佩士來大學博士學位
英國愛丁堡大學博士後
中國科學院院士,（973）首席科學家
代表文章：
(1). Chen L, Qin S, Xie J, Tang J, Yang L, Shen W, Zhao X, Du J, He G, Feng G, He L, Xing Q.Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China。 Pharmacogenomics. 2008 Jun;9(6):691-702.
(2). Xu MQ, St Clair D, Feng GY, Lin ZG, He G, Li X, He L.BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population. Pharmacogenet Genomics. 2008 Jun;18(6):449-57.
(3). Ma J, Fan JB, Bian L, Zhang CS, Li XW, Gu NF, Feng GY, St Clair D, He L. Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population.Psychiatry Res. 2008 May 30;159(1-2):245-9.
(4). Du J, Duan S, Wang H, Chen W, Zhao X, Zhang A, Wang L, Xuan J, Yu L, Wu S, Tang W, Li X, Li H, Feng G, Xing Q, He L. Comprehensive analysis of polymorphisms throughout GAD1 gene: a family-based association study in schizophrenia.J Neural Transm. 2008;115(3):513-9.
(5). Xu MQ, Ye Z, Hu FB, He L. Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease.Circulation. 2007 Sep 18;116(12):1356-66.
(6). Xing Q, Gao R, Li H, Feng G, Xu M, Duan S, Meng J, Zhang A, Qin S, He L.Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics. 2006 Oct;7(7):987-93.
(7). Li D, He L. Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis.Eur J Hum Genet. 2006 Oct;14(10):1130-5.
(8). Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L.Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001 Aug;28(4):386-8.
15 南開大學校長饒子和教授
澳大利亞墨爾本大學博士
牛津大學結構生物學博士後
中國科學院院士
中國科學院生物物理所前所長
代表文章：
(1). Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Comples Ⅱ. Cell, 121: 1043-1057
(2). Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ, J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752
(3). Zhai Y, Sun F, Li X, Pang H, Bartlam M & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7?nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986
(4). Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22):8348-8353
(5). Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y & Rao Z*. 2004. Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1. Structure, 12(8):1481-1488Xu Y, Liu Y, Lou Z, Qin L, Bai Z, Pang H, Tien P, Gao G* & Rao Z*. 2004. Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core. J Biol Chem., 279 (29): 30514-30522
(6). Yang H, Yang M, Ding Y, Liu Y, Lou Z, Sun L, Zhou Z, Ye S, Pang H, Gao G, Anand K, Bartlam M, Hilgenfeld R & Rao Z*. 2003. The Crystal Structures of SARS Virus Main Protease Mpro and Its Complex with an Inhibitor. Proc Natl Acad Sci USA., 100(23): 13190-13195
(7). Ding Y, Xu M, I Ghosh, Chen Xi, S. Ferrandon, G. Lesage & Rao Z*. 2003. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem., 278(40): 39133 - 39142.
(8). Rao Z, Belyaev A, Fry E, Jones I, Roy P＆Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature，378(6558): 743-747.
(9). Rao Z, Handford P, Mayhew M, Knott V, Brownlee G＆Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141.
（飄俠編輯，轉載請注明來源）
中山大學副校長，長江學者特聘教授
中國醫學科學院病毒所博士
美國皮茨堡大學博士後
美國皮茨堡大學助教授
代表文章：
（1). Frank Riedel, Karl Götte, Mengfeng Li, Karl Hörmann, *Jennifer Rubin Grandis (corresponding author). Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo. International Journal of Oncology. 2003, 23(3): 577-83.
（2). Hideo Niwa, Abbey Wentzel, Mengfeng Li, William L. Gooding, Vivian Wai Yan Lui, *Jennifer Rubin Grandis (corresponding author). Antitumor Effects of EGFR Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck. Clinical Cancer Research, 2003, 9:5028–5035.
（3). Caisheng Ye, Chong Feng, Xiaoning Liu, Shenming Wang, Yongjie Lin and *Mengfeng Li (corresponding author). sFlt-1 gene therapy of follicular thyroid carcinoma. Endocrinology, 2004, 145 (2): 817-822.
（4). Chong Feng, Caisheng Ye, Xiaoning Liu, Hong Ma and *Mengfeng Li (corresponding author). b4 integrin is involved in statin-induced endothelial cell death, Biochem Biophys Res Commun. 2004, 323(3): 858-64.
（5). Zhuo Chen, Xin Zhang, Mengfeng Li, Zhiqiang Wang, Harry Samuel Wieand, Jennifer Rubin Grandis, *Dong Moo Shin (corresponding author). Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004, 10(17): 5930-9.
（6). 葉財盛、王深明、林勇傑、劉曉寧、*黎孟楓（通訊作者），轉內皮抑素基因通過抑製血管生成抑製甲狀腺濾泡狀癌生長.中國實用外科雜誌，2003，23（3）：153-156.
（7). 葉財盛、王深明、林勇傑、鄭朝旭、劉曉寧、*黎孟楓（通訊作者），甲狀腺濾泡狀癌抗血管生成治療的實驗研究，中國實用外科雜誌，2004, 24 (11): 688-690.
9. 中國科學院北京基因組研究所新所長吳仲義教授
加拿大 British Columbia大學 群體遺傳學專業博士
美國Wisconsin大學Madison分校遺傳學實驗室博士後
美國芝加哥大學生態學與進化係教授、係主任，
台灣中央研究院院士
代表文章：
(1). Ting, C.-T., S.-C. Tsaur, M.-L. Wu and C.-I Wu, 1998 A rapidly evolving homeobox at the site of a hybrid sterility gene. Science 282: 1501-1504.
(2). Fay, J. C. and C.-I Wu, 1999 A human population bottleneck is not incompatible with the discordance between patterns of mitochondrial vs. nuclear DNA variation. Molec. Biol. Evol. 16:1003 - 1006.
(3). Wyckoff, G. J., W. Wang and C.-I Wu, 2000 Rapid evolution of male reproductive genes in the descent of man. Nature 403: 304 - 309.
(4). Sawamura, K., A. W. Davis and C.-I Wu, 2000 Genetic analysis by means of introgression into Drosophila melanogaster. Proc. Natl. Acad. Sci. 97:2652-2655.
(5). Wang, H-Y., H. Tang, C. K. Shen and C.-I Wu 2003 Rapidly evolving genes in human –
I. The glycophorins and their possible role in evading malaria parasites. Mol. Biol. Evol. 20:1795-1804.
Greenberg, A. J., J. R. Moran, J. A. Coyne, and Chung-I Wu 2003 Ecological adaptation during incipient speciation as revealed by precise gene replacement. Science 302: 1754-1757.
(6). Lu, J., W.-H. Li and C.-I Wu. 2003 Chromosomal speciation and gene flow. Science 302:988c.
Wu, C.-I, S. Shi and Y. Zhang 2004 A case for conservation. Nature 428:213-214. (A commentary in a supplementary issue).
(7). He, J et al. (51 authors) 2004. Molecuar evolution of the SARS-conronavirus during the course of SARS-epidemic in China. Science 303: 1666-1669 (C.-I Wu is a communicating author for the data analysis section).
(8). Sun, S, C. Ting, and C.-I Wu 2004 The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Science 305: 81-83.
(9). Song, H.-D. et al. C.-I Wu and G.-P. Zhao 2005 Cross-host evolution of SARS coronavirus in palm civet and human. Proc. Natl. Acad. Sci. 102: 2430-2435
(10). Lu J, Tang T, Tang H, Huang J, Shi S, Wu C-I. 2006 The accumulation of deleterious mutations in rice genomes: a hypothesis on the cost of domestication. Trends in Genetics 22：126-131.
10. 清華大學生命科學與醫學院副院長施一公教授
The Johns Hopkins 大學生物物理學博士
紐約斯隆/凱特林癌症研究中心結構生物學實驗室博士後
普林斯頓大學Warner-Lambert/Parke-Davis終身教授
美國休斯醫學研究所研究員
代表文章：
(1). Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A.Cell. 2008 Apr 4;133(1):154-63.
(2). Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y. Structure of a site-2 protease family intramembrane metalloprotease.Science. 2007 Dec 7;318(5856):1608-12.
(3). Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.Nature. 2008 Mar 6;452(7183):56-61.
(4). Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y.Structure of a site-2 protease family intramembrane metalloprotease. Science. 2007 Dec 7;318(5856):1608-12.
(5). Yan N, Shi Y. Allosteric activation of a bacterial stress sensor. Cell. 2007 Nov 2;131(3):441-3.
(6). Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue, and Yigong Shi (2005). Structure of the CED-4/CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.Nature 437, 831–837.
(7). Stefan J. Riedl, Wenyu Li, Yang Chao, Robert Schwarzenbacher, and Yigong Shi (2005). Structure of the apoptotic protease activating factor 1 (Apaf-1) bound to ADP. Nature 434, 926–933.
(8). Nieng Yan, Lichuan Gu, David Kokel, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi (2004). Structural, Biochemical and Functional Analyses of CED-9 Recognition by the Pro-apoptotic Proteins EGL-1 and CED-4. Mol. Cell 15, 999–1006.
(9). Eric N. Shiozaki, Jijie Chai, Daniel J. Rigotti, Stefan J. Riedl, Pingwei Li, Srinivasa M. Srinivasula, Emad S. Alnemri, Robert Fairman, and Yigong Shi (2003). Mechanism of XIAP-mediated Inhibition of Caspase-9. Mol.Cell 11, 519-527.
(10). Jijie Chai Qi Wu, Eric Shiozaki, Srinivasa M. Srinivasula, Emad S. Alnemri, and Yigong Shi (2001). Crystal Structure of a Caspase Zymogen: Mechanisms of Activation and Substrate Binding. Cell 107, 399-407.
(11). Jijie Chai, Eric Shiozaki, Srinivasa M. Srinivasula, Qi Wu, Pinaki Datta, Emad S. Alnemri, and Yigong Shi (2001). Structural Basis of Caspase-7 Inhibition by XIAP. Cell 104, 769-780.
(12). Geng Wu, Jijie Chai, Tomeka Suber, Jia-Wei Wu, Chunying Du, Xiaodong Wang, and Yigong Shi (2000). Structural Basis of IAP Recognition by Smac/DIABLO. Nature408, 1008-1012.
(13). Jijie Chai, Chunying Du, Jia-Wei Wu, Saw Kyin, Xiaodong Wang, and Yigong Shi (2000). Structural and Biochemical Basis of Apoptotic Activation by Smac/DIABLO. Nature 406, 855-862.
(14). Hongxu Qin, Srinivasa M. Srinivasula, Geng Wu, Emad S. Alnemri, Yigong Shi (1999). Structural Basis of Procaspase-9 Recruitment by the Apoptotic Protease Activating Factor 1. Nature 399, 549-557.
11. 清華大學醫學院首屆院長吳階平院士
中國泌尿外科的先驅者之一， 2001 年受聘為清華大學醫學院首屆院長。吳階平院士曾任第八、九屆全國人大常委會副委員長。是中國科學院院士，中國工程院院士，第三世界科學院院士，美國醫師學院榮譽院士，比利時皇家醫學科學院院士，英國愛丁堡皇家外科醫師學院名譽院士，香港皇家外科醫師學院院士；中國科學技術協會名譽主席，中華醫學會名譽會長，中國醫學科學院名譽院長，中國協和醫科大學名譽校長，首都醫科大學終身名譽校長，南京大學醫學院名譽院長，和全國著名大學、學院、研究機構等二十餘家單位的名譽校長、名譽教授，以及國外著名大學、學院的榮譽院士或榮譽博士。
吳階平院士長期從事泌尿外科的臨床治療和科研工作，是中國泌尿外科的先驅者之一，在腎結核對側腎積水和腎上腺髓質增生研究中有獨創性見解。 1957 年首創用輸精管結紮並用精囊灌注術，增強了避孕效果，是我國男性節育技術的奠基人。 50 年代，首先提出的腎結核對側腎積水的概念，被國內外公認為“在臨床上有極重大的意義”，並率先利用回盲腸行膀胱擴大術治療膀胱攣縮取得成功，到 70 至 80 年代國外才作為最新方法介紹給公眾。 60 年代設計了特殊的導管改進前列腺增生的手術，使手術出血量大為減少，手術時間縮短，被稱為“吳氏導管”。 1977 年提出的“腎上腺髓質增生”是一個獨立的疾病，被收進 1979 年《美國泌尿外科年鑒》。 1995 年“吳階平泌尿外科醫學基金會”在北京成立。
12. 複旦大學發育生物和分子醫學研究所所長許田教授
耶魯大學遺傳學博士
耶魯大學遺傳學博士後
美國休斯醫學研究所研究員
耶魯大學醫學院遺傳係教授，副係主任
代表性文章：
（1). Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T. (2007). Tumor Suppressor CYLD Regulates JNK Induced Cell Death in Drosophila. Dev Cell 13:446-454.
(2). Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. (2005). Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice. Cell 122(3):473-483.
(3). Yang XL, Yu KP, Hao YW, Li D-M, Stewart R, Insogna KL, Xu T. (2004). LATS1 tumor suppressor affects cytokinesis by inhibiting LIMK1. Nature Cell Biology 6:609-617.
(4). Pagliarini, R.A., and Xu, T. (2003). A genetic screen in Drosophila for metastatic behavior. Science, 302(5648):1227-31.
(5). Potter CJ, Pedraza LG, Xu T. (2002). Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol., 4: 658-665.
(6). Zhang S, Xu L, Lee J, Xu T. (2002). Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes. Cell, 108: 45-56.
(7). Potter, C. J., Huang, H. and Xu, T. (2001). Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell, 105:357-368.
(8). Tao, W., Zhang, S., Turenchalk, G.S., Stewart, R.A., Chang, W., St. John, M.A.R., and Xu, T. (1999). Human homolog of the Drosophila melanogaster lats tumor suppressor modulates CDC2 activity. Nature Genetics, 21:177-181.
(9). St. John, M.A.R., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., A.F. Parlow, McGrath, J., and Xu, T. (1999). Mice deficient of Lats1 develop soft tissue sarcomas, ovarian tumors and pituitary dysfunction. Nature Genetics, 21:182-186.
(10). Qi, H., Rand, M., Wu, X., Sestan, N., Wang, W., Rakic, P., Xu, T., and Artavanis-Tsakonas, S. (1999). Processing of the Notch ligand Delta by the Metalloprotease Kuzbanian. Science, 283:91-94.
13. 北京生命科學研究所鄧興旺共同所長
加州大學伯克萊分校生物學博士
北大耶魯植物遺傳學聯合研究中心主任
耶魯大學計算生物學與生物信息學講座教授
(1). Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM & Deng XW.
Coordinated regulation of Arabidopsis thaliana development by light and gibberellins.Nature2008 Jan 24; 451(475-479).
(2). Li L, Wang X, Sasidharan R., Stolc V, Deng W, He H, Korbel J, Chen X, Tongprasit W, Ronald P, Chen R, Gerstein M, Deng XW. Global Identification and Characterization of Transcriptionally Active Regions in the Rice Genome
PLoS ONE.2007; 2(3): e294。
（3）. Li L, Wang X, Stolc V, Li X, Zhang D, Su N, Tongprasit W, Li S, Cheng Z, Wang J, Deng XW. Genome-wide transcription analyses in rice using tiling microarrays.Nature Genetics.2006 Jan;38: 124 – 129.
(4).Rubio V, Deng XW. Phytunes: phosphorylation status and phytochrome-mediated signaling. Cell. 2005 Feb 11;120(3):290-2.
(5). Yanagawa Y, Sullivan JA, Komatsu S, Gusmaroli G, Suzuki G, Yin J, Ishibashi T, Saijo Y, Rubio V, Kimura S, Wang J, Deng XW. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 2004 Sep;18: 2172-2181.
(6). Saijo Y, Sullivan JA, Wang H, Yang J, Shen Y, Rubio V, Ma L, Hoecker U, Deng XW. The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. Genes Dev. 2003 Nov 1;17(21):2642-7.
(7). Suzuki G, Yanagawa Y, Kwok SF, Matsui M, Deng XW. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 2002 Mar 1;16(5):554-9.
(8).Wang H, Ma LG, Li JM, Zhao HY, Deng XW. Direct Interaction of Arabidopsis Cryptochromes with COP1 in Mediation of Photomorphogenic Development. Science 2001 Oct 5;294(5540):154-8.
14. 複旦大學生物醫學研究院院長賀林
英國佩士來大學博士學位
英國愛丁堡大學博士後
中國科學院院士,（973）首席科學家
代表文章：
(1). Chen L, Qin S, Xie J, Tang J, Yang L, Shen W, Zhao X, Du J, He G, Feng G, He L, Xing Q.Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China。 Pharmacogenomics. 2008 Jun;9(6):691-702.
(2). Xu MQ, St Clair D, Feng GY, Lin ZG, He G, Li X, He L.BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population. Pharmacogenet Genomics. 2008 Jun;18(6):449-57.
(3). Ma J, Fan JB, Bian L, Zhang CS, Li XW, Gu NF, Feng GY, St Clair D, He L. Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population.Psychiatry Res. 2008 May 30;159(1-2):245-9.
(4). Du J, Duan S, Wang H, Chen W, Zhao X, Zhang A, Wang L, Xuan J, Yu L, Wu S, Tang W, Li X, Li H, Feng G, Xing Q, He L. Comprehensive analysis of polymorphisms throughout GAD1 gene: a family-based association study in schizophrenia.J Neural Transm. 2008;115(3):513-9.
(5). Xu MQ, Ye Z, Hu FB, He L. Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease.Circulation. 2007 Sep 18;116(12):1356-66.
(6). Xing Q, Gao R, Li H, Feng G, Xu M, Duan S, Meng J, Zhang A, Qin S, He L.Polymorphisms of the ABCB1 gene are associated with the therapeutic response to risperidone in Chinese schizophrenia patients. Pharmacogenomics. 2006 Oct;7(7):987-93.
(7). Li D, He L. Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis.Eur J Hum Genet. 2006 Oct;14(10):1130-5.
(8). Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L.Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001 Aug;28(4):386-8.
15 南開大學校長饒子和教授
澳大利亞墨爾本大學博士
牛津大學結構生物學博士後
中國科學院院士
中國科學院生物物理所前所長
代表文章：
(1). Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Comples Ⅱ. Cell, 121: 1043-1057
(2). Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ, J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752
(3). Zhai Y, Sun F, Li X, Pang H, Bartlam M & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7?nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986
(4). Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22):8348-8353
(5). Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y & Rao Z*. 2004. Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1. Structure, 12(8):1481-1488Xu Y, Liu Y, Lou Z, Qin L, Bai Z, Pang H, Tien P, Gao G* & Rao Z*. 2004. Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core. J Biol Chem., 279 (29): 30514-30522
(6). Yang H, Yang M, Ding Y, Liu Y, Lou Z, Sun L, Zhou Z, Ye S, Pang H, Gao G, Anand K, Bartlam M, Hilgenfeld R & Rao Z*. 2003. The Crystal Structures of SARS Virus Main Protease Mpro and Its Complex with an Inhibitor. Proc Natl Acad Sci USA., 100(23): 13190-13195
(7). Ding Y, Xu M, I Ghosh, Chen Xi, S. Ferrandon, G. Lesage & Rao Z*. 2003. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem., 278(40): 39133 - 39142.
(8). Rao Z, Belyaev A, Fry E, Jones I, Roy P＆Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature，378(6558): 743-747.
(9). Rao Z, Handford P, Mayhew M, Knott V, Brownlee G＆Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141.
（飄俠編輯，轉載請注明來源）
最近不太忙，就嗮一嗮我們國家的這些學術掌門人，好讓大家監督他們，把科學搞上去。