數一數當今幹細胞研究方麵的頂尖科學家(1)

前5位頂尖科學家是：

第一位：Shinya Yamanaka，Ph.D. 日本京都大學前沿醫學研究所幹細胞生物學係，加州大學舊金山分校心血管疾病研究所教授

代表作文章

1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S.
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Cell. 2007 Nov 30;131(5):861-72.

2. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent
stem cells. Nature. 2007 Jul 19;448(7151):313-7.

3. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K,
Mochiduki Y, Takizawa N, Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol. 2007 Nov 30;

4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10

5. Takahashi K, Ichisaka T, Yamanaka S. Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol. 2006;329:449-58.

並列第一位：

JamesA.Thomson Ph.D.威斯康星大學基因組研究中心主任，解剖學係教授

代表作文章

1. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells。 Science. 2007 Nov 20

2. Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA.
Feeder-independent culture of human embryonic stem cells. Nat Methods. 2006 Aug;3(8):637-46

3. Ludwig TE, Levenstein ME, Jones JM, Berggren WT, Mitchen ER, Frane JL, Crandall LJ, Daigh CA, Conard KR, Piekarczyk MS, Llanas RA, Thomson JA.Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol. 2006 Feb;24(2):185-7.

4. Yu J, Vodyanik MA, He P, Slukvin II, Thomson JA. Human embryonic stem cells reprogram myeloid precursors following cell-cell fusion. Stem Cells. 2006 Jan;24(1):168-76. Epub 2005 Oct 6

5. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA. Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5.

第二位： Rudolf Jaenisch MD，麻省理工學院白頭生物研究所教授

代表作文章

1. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R. Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin. Science. 2007 Dec 6；

2. Meissner A, Wernig M, Jaenisch R.Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol. 2007 Oct;25(10):1177-81；

3. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
Nature. 2007 Jul 19;448(7151):318-24；

4. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature. 2006 May 18;441(7091):349-53；

5. Meissner A, Jaenisch R. Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts. Nature. 2006 Jan 12;439(7073):212-5。

第三位： Rebort lanza Ph.D. 麻省先進細胞公司首席科學家，北卡州Wake Forest 大學醫學院教授

1. Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R. Human embryonic stem cell lines derived from single blastomeres. Nature. 2006 Nov 23;444(7118):481-5.

2. Lu SJ, Feng Q, Caballero S, Chen Y, Moore MA, Grant MB, Lanza R. Generation of functional hemangioblasts from human embryonic stem cells. Nat Methods. 2007 Jun;4(6):501-9

3. Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, Meisner L, Lanza R. Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature. 2006 Jan 12;439(7073):216-9.

4. Lanza RP, Chung HY, Yoo JJ, Wettstein PJ, Blackwell C, Borson N, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A. Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol. 2002 Jul;20(7):689-96.

5. Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Chavez EA, Sawyer N, Lansdorp PM, West MD. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science. 2000 Apr 28;288(5466):665-9

第四位：Alan Trounson Ph.D. 加州再生醫學研究研究所所長，教授（原澳大利亞Monash大學免疫學和幹細胞研究實驗室主任）

代表作文章

1. GQ Daley, L AhrlundRichter,JM Auerbach, N Benvenisty, RA Charo, G Chen, HK
Deng,LS Goldstein, KL Hudson, I Hyun, SC Junn, J Love, EH Lee, A McLaren, CL Mummery,N Nakatsuji, C Racowsky, H Rooke, J Rossant, HR Scholer, JH Solbakk, P Taylor, AO Trounson, IL Weissman, I Wilmut, J Yu, L Zoloth (2007) The ISSCR Guidelines for Human Embryonic Stem Cell Research. Science 315: 603604. 303.

2. A Giudice and A Trounson (2007) Genetic manipulation of human embryonic stem cells for cell based therapy. Nature Biotech；

3. M Snow, SL Cox, G Jenkin, A Trounson, J Shaw (2002) Generation of live young from xenografted mouse ovaries. Science 297: 2227.

4. BE Reubinoff, MF Pera, CY Fong, A Trounson, A Bongso (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechn. 18: 399404.

5. AT Dowsing, EL Yong, M Clark, RI McLachlan, DM de Kretser, AO Trounson (1999)
Linkage between male infertility and trinucleotide repeat expansion in the androgen
receptor gene. Lancet 354: 640643.

第五位：Douglas A. Melton, Ph.D，哈佛大學幹細胞研究所所長，Howard Hughes Medical Institute 研究員。

代表作文章

1. Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 2007 Feb 22;445(7130):886-91.

2. Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science. 2005 Aug 26;309(5739):1369-73.

3. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004 May 6;429(6987):41-6.

4. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science. 2003 Jan 17;299(5605):363.

5. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": tranional profiling of embryonic and adult stem cells. Science. 2002 Oct 18;298(5593):597-600.

並列第5位Irving L. Weissman MD. 斯坦福大學幹細胞和再生醫學研究所所長

代表作文章

1. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age." Nature 2007; 447: 7145: 725-9

2. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.
Cell. 2006 Jul 28;126(2):415-26

3. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29;123(7):1351-60

4. De Tomaso AW, Nyholm SV, Palmeri KJ, Ishizuka KJ, Ludington WB, Mitchel K, Weissman IL. Isolation and characterization of a protochordate histocompatibility locus.
Nature. 2005 Nov 24;438(7067):454-9

5. Passegué E, Wagner EF, Weissman IL. JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell. 2004 Oct 29;119(3):431-43.

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[涯風]

Very interesting. Thanks for introduction.