Time Line
2000: Got married. 10-year marriage up to August, 2010
2008, some time before July, their son was born.
(It is natural to assume that they were under the stress of taking care of the
newborn since then.)
September, 2008, moved to Monroe (should be Monroe Township, according to
their property address), New Jersy.
They purchased a house in September.
Seven months later they started to call police due to bitter arguments.
April 2009 ~ July, 2010, More than 5 times call to police due to arguments.
No one was injured and no restraining orders were ever filed as a result of the
police visits.
(The reasons of arguments have not been released by police.)
June, 2010, Wang moved out of the couple's home on Stanley Drive home in Monroe
and into a Jersey City apartment.
July, 2010, Wang, 39, filed for divorce, citing irreconcilable differences.
He also sought joint custody of the couple’s 2-year-old son, Isaac.
August, 2010, Li, 40, counter-sued, citing the same reason and adding there was
"no hope for reconciliation."
Jan. 14, 2011, the day a hearing would be held to finalize the divorce, Wang
admitted himself to the University Medical Center in Princeton with "virus-like"
symptoms. He died 12 days later from thallium poisoning, which authorities allege
was administered by his wife.
View Larger Map
A: Stanley Dr, MONROE TOWNSHIP, Middlesex, New Jersey 08831 (Their home before separated)
B: Bristol-Myers Squibb Company: U S Headquarters (The company Li worked for)
Princeton University Medical Center (where Wang visited and died) is right above B.
A-B: about 18 miles, 37 min driving.
View Larger Map
A. Jersey City that Wang moved to in June, 2010.
B. Princeton University Medical Center (where Wang visited and died).
A-B: 46.4 miles, 1 hour 4 mins driving according to Google maps.
Thallium poisoning typically includes loss of hair, thickened skin, severe
gastrointestinal pain and loss of feeling in the extremities. Wang didn't present
many of those symptoms until a few days after his arrival, Marcus said.
Jan. 22 or 23, 2011, Wang lapsed into a coma. Wang did not respond to treatment
and continued to worsen.
At that point a nurse recalled cases of thallium poisoning in China in the 1990s
and suggested Wang's urine be tested, Sewitch said. No lab in New Jersey was
capable of performing the test, so Wang's urine sample was sent out of state.
Twenty-four hours later, the diagnosis of thallium poisoning was confirmed and
Marcus was notified.
Jan. 25, 2011, around 9 p.m., Steven Marcus, the medical and executive director
of New Jersey Poison Control, received a call from University Medical Center in
Princeton. A doctor was on the other end of the line telling him about Wang
and that thallium had been discovered in his system.
...Steven Marcus launched efforts to seek treatment...
Nearly two hours after leaving his home, Marcus arrived in Princeton. The
non-medical grade Prussian Blue had been administered through a gastric tube,
but Wang had showed no response.
In the meantime, Marcus had contacted a federal facility near Albany, N.Y., that
had the purer form of the antidote, and an SUV was dispatched to Princeton. When
it finally arrived five hours later, Wang was near death.
The antidote would be useless. Marcus, along with a number of doctors and nurses,
stood beside Wang'bed, unable to do anything more.
Sometime around 3 p.m. on Jan. 26, as several detectives stood nearby, Wang's
heart monitor flatlined.
Jan, 26, 2011, around 3 p.m., Wang died.
Jan, 28, 2011, Li was initially charged with hindering her own
apprehension after she made false statements to investigators on Jan. 28, two
days after her hu*****and died, The Star-Ledger reported.
The New Jersey State Police and Middlesex County Hazardous Materials Units
conducted a search of the Wang's Middlesex County home and concluded that
no one else had been exposed to the toxic metal.
According to the Middlesex County Prosecutor's Office, Li obtained an
undetermined amount Thallium and fed it to her hu*****and sometime in December
2010 or January 2011. Nicholas Sewitch, deputy assistant Middlesex County
prosecutor, declined to release specifics on how Li allegedly poisoned Wang.
At room temperature, Thallium is a very pliant, dissolvable metal you can
cut with a knife. It is easily absorbed through the skin by inhalation, or
ingested orally. Thallium dissolves quickly in liquids so if one were to use
it as a poison; its salts are colorless, odorless and tasteless, therefore
making it undetectable in food or soft drinks. Thallium poisoning takes
several days to manifest so one would not know they have been poisoned right
away.
Dr. Anil Aggrawal, professor of Forensic Medicine and Editor-in-Chief of
the Internet Journal of Forensic Medicine and Toxicology said the amount
of Thallium needed to kill a human being would be about 0.6 to 0.7g,
considered the somewhat less than the average dose, and death would likely
occur within 11 to 16 days.
Feb. 8, 2011. Hearing in which Li was charged with the murder of Xiaoye Wang, 39.
Tianle Li, 40, dressed in green jail garb and wearing gold glasses, calmly listened
as Superior Court Judge Michael Toto explained her rights and what legal procedures
would follow today's hearing.
Li remained at the Middlesex County jail in North Brunswick today in lieu of
$4.15 million bail, charged with murder and hindering her own apprehension by
"lying to police" when they began investigating Wang's death, Sewitch said.
Her attorney, Steven Altman, said his client denies having anything to do with
her hu*****and's death.
Feb. 10, 2011, the divorce hearing, which was postponed due to his illness, had
been rescheduled for today.
Note: The information was from the published articles quoted on the bottom of this post.
----------------------------------------------------------------------------
http://bbs.wenxuecity.com/myhouse/1653693.html
誰個8一8為啥老婆投毒害老公 俺先提點信息
幾天前在法壇看過求助貼，估計就是這事。
急！兄弟在美國被毒死，他老婆正在被調查。大俠們，該怎麽辦？
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http://bohuamei.blog.163.com/blog/static/9036403420111935647538/
http://bbs.wenxuecity.com/rdzn/1543129.html
http://www.cnd.org/my/modules/newbb/viewtopic.php%3Ftopic_id=71122&forum=1
http://bbs.wenxuecity.com/myhouse/1653598.html
http://bbs.wenxuecity.com/myhouse/1653197.html
一些以前的照片：
http://bbs.wenxuecity.com/rdzn/1549813.html
涉嫌以鉈毒死丈夫的李女今日首次開庭露麵(組圖) 文學城綜合新聞
李天樂(譯音) "Heidi" 圖左, 被控以謀殺罪出庭. 死者王曉業
圖右Steve Altman李的律師, 在法庭聆聽助理檢察官指控的情形.
<文學城綜合新聞報導>被控在上個月以有毒重金屬鉈謀殺丈夫的嫌犯李天樂今日下午在新澤西密德塞斯郡法院首次出庭，40歲的嫌犯李天樂今天身穿綠色的囚服戴著金框眼鏡在律師陪同下，表情看似鎮靜的在庭上聆聽高等法院法官Michael Toto 向他解釋她的權利以及法庭審理的程序。
美國新澤西州40歲女華裔化學師李天樂(Tianle Li)，被密德塞斯郡(Middlesex County)檢察官辦公室指控，以具有強烈毒性的放射物質鉈(thallium)謀殺39歲丈夫王曉業(Xiaoye Wang，譯音)。王曉業已於1月26日死亡，李天樂否認毒殺丈夫，並準以415萬美金保釋，案件於2月9日在新布朗士維克高等法院首次開庭。
擔任軟件工程師的王曉業在1月14日因感冒症狀前往普林斯頓大學醫療中心檢查，經過兩個星期的治療，情況未好轉並趨於嚴重，因而進行一連串的測試檢驗，25日檢驗報告證實王曉業鉈中毒，院方立即舉報，聯邦調查局及有關當局便開始介入調查。26日王曉業被院方宣布不治身亡。兩天後，其太太李天樂遭逮捕。
根據郡檢察官Nicholas Sewitch的說明指稱，當死者王曉業在普林斯頓大學醫療中心檢查和治療的過程中懷疑可能是鉈中毒的原因是由於當時在普林斯頓大學醫療中心就職的一名護士在這過程中提出了一個質疑，該名護士提到了她是因為想起了在90年代在中國發生一起鉈中毒殺人事件才提醒醫生檢測王曉業體內的鉈含量。
在必治妥施貴寶製藥公司(Bristol-Myers Squibb)擔任化學師十年的李天樂，近月數次向公司申請取得鉈。經過偵訊，檢方表示李天樂在2010年12月至 2011年1月之間，對她的丈夫王曉業使用了部分鉈，至於如何使用，用量多少，檢方以仍在偵查階段不願透露。
李天樂堅持自己是無辜的，其辯護律師艾特曼說：“我的客戶堅決否認涉入她丈夫的死亡，她沒有原因或動機要他死”。他表示，李天樂與王曉業的離婚手續已經趨於完成階段，且協議書中列明王曉業必須負擔兒子的學費及撫養費，因此沒有合理的殺人動機。艾特曼表示，李天樂在美國沒有其它家人，被捕後，她的兒子即被當局帶走，由新州青年與家庭服務處監護，並安置到寄養家庭，目前正等待她的家人從中國來美，幫助照顧這個孩子。
李天樂和王曉業皆來自中國，據消息來源指出，李畢業於北京大學，王畢業於清華大學，兩人育有一名兩歲男童。2008年搬入位於新澤西州孟洛鎮的史坦利街居處，次年婚姻開始出現問題，正在辦理離婚手續。一位鄰居表示，2010年每星期警察都會接獲報案到他們家中勘查1至2次；另一位住在對街的鄰居則表示，經常聽到爭吵聲，且太太的聲音比丈夫大又尖銳。附近鄰居皆表示，很少與王李夫婦打交道，與他們不熟識，但都知道他們感情不好，時常吵架。
李天樂出庭照片（十張）
Bristol-Myers Squibb chemist Tianle Li accused of using thallium to kill hu*****and
BY ALICIA CRUZ
NEWJERSEYNEWSROOM.COM
A Bristol-Myers Squibb chemist has been charged with fatally poisoning her estranged hu*****and using an extremely toxic compound, the Associated Press reported Wednesday.
Tianle Li, 40, did not appear in New Brunswick, N.J. Superior Court Wednesday, instead her attorney entered a not guilty plea on her behalf.
Investigators say Li, who goes by the name Heidi, was charged with murder after an autopsy confirmed the presence of Thallium, a chemical element commonly used in the pharmaceutical and electronics industries as well as glass manufacturing. Thallium, considered highly toxic, was used in rat and ant poisons during the 1970s.
Li's hu*****and, Xiaoye Wang, fell ill with flu-like symptoms in January and was admitted to University Medical Center in Princeton, N.J.. For two weeks, Wang baffled doctors when his condition failed to improve. On January 25, a series of tests returned showing Wang had been poisoned by Thallium.
The 39-year-old computer engineer died January 26, and special agents from Newark's FBI office and the State Police launched a thorough investigation to find out who poisoned the Monroe Township man and why.The trail led to his wife who was in the process of divorcing Wang. She was initially charged with hindering her own apprehension after she made false statements to investigators on Jan. 28, two days after her hu*****and died, The Star-Ledger reported.
The New Jersey State Police and Middlesex County Hazardous Materials Units conducted a search of the Wang's Middlesex County home and concluded that no one else had been exposed to the toxic metal.
According to the Middlesex County Prosecutor's Office, Li obtained an undetermined amount Thallium and fed it to her hu*****and sometime in December 2010 or January 2011. Nicholas Sewitch, deputy assistant Middlesex County prosecutor, declined to release specifics on how Li allegedly poisoned Wang.
At room temperature, Thallium is a very pliant, dissolvable metal you can cut with a knife. It is easily absorbed through the skin by inhalation, or ingested orally. Thallium dissolves quickly in liquids so if one were to use it as a poison; its salts are colorless, odorless and tasteless, therefore making it undetectable in food or soft drinks. Thallium poisoning takes several days to manifest so one would not know they have been poisoned right away.
Dr. Anil Aggrawal, professor of Forensic Medicine and Editor-in-Chief of the Internet Journal of Forensic Medicine and Toxicology said the amount of Thallium needed to kill a human being would be about 0.6 to 0.7g, considered the somewhat less than the average dose, and death would likely occur within 11 to 16 days.
Some of the corollary effects of thallium poisoning include lethargy, diarrhea, vomiting, severe pain, hair loss, and damage to peripheral nerves. Poisoning can affect multiple organs including the heart, lungs, kidneys, and liver. A person poisoned by Thallium can live up to two weeks or more with medical treatment (antidote Prussian blue), but any damages to their organs would be permanent, said Dr. Aggrawal. Doctors test hair follicles to determine poisoning by Thallium.
Doctors administer Thallium stress tests to check for heart disease or to see how well blood is flowing to the heart muscle, and where the heart muscle may not be getting a normal blood supply.
Bruce Kaplan, the Middlesex County prosecutor, said in a press release that the Wangs marriage became onerous a year after the Chinese natives had a son and moved into their Monroe Township home in 2008. Kaplan also said there were several domestic disturbance calls made from the Stanley Drive home in 2009.
"My client adamantly denies any involvement in her hu*****and's death," Li's attorney Steve Altman told The Courier Post. Altman said Li, employed at the New York based biopharmaceutical company since 2001, and Wang had recently come to an agreement on a property settlement related to their divorce and Wang was paying for support of his son.
"She has no reason or motive to want him dead," said Altman. A representative at Bristol-Meyers Squibb, which has research sites in Princeton, Hopewell and New Brunswick, refused to make any comment to NewJerseyNewsroom.com concerning Li's arrest.
Li was arraigned around 1:30 p.m. Wednesday, and is currently being held at the Middlesex County Adult Correction Center in New Brunswick in lieu of $4.15 million bail. Superior Court judge Bradley Ferencz set Li's hindering apprehension bail at $150,000 and $4 million for the murder charge.
When Li was arrested, her 2-year-old son was given to the state Division of Youth and Family Services and placed in a foster home, the NJ Press Media reported.
"She [Li] has no family in the United States,'' said Altman. "We're waiting for family to come from China to help with the child.''
Anyone with further details on this case should call Sgt. Jason Grosser of the Monroe Township Police Department at 732-521-0222 or Investigator Jeffrey Temple of the Middlesex County Prosecutor's office at 732-745-3373.
Monroe woman pleads not guilty to fatally poisoning hu*****and
Published: Wednesday, February 09, 2011, 2:49 PM Updated: Wednesday, February 09, 2011, 3:31 PM
MONROE — A Monroe Township woman entered a plea of not guilty this afternoon to charges she poisoned her hu*****and, who died last month, with thallium, a highly toxic metal.
Tianle Li, 40, dressed in green jail garb and wearing gold glasses, calmly listened as Superior Court Judge Michael Toto explained her rights and what legal procedures would follow today's hearing.
Li was charged Tuesday with the murder of Xiaoye Wang, 39, who died Jan. 26 at University Medical Center in Princeton. He brought himself to the hospital Jan. 14 with what authorities now call "virus-like" symptoms.
After the hearing, Nicholas Sewitch, deputy first assistant Middlesex County prosecutor, said Wang received a "lethal, massive dose of thallium," but said he could not comment on how it was administered or whether it was all given at once or over a period of time.
"There are additional toxicological tests being run on the victim's tissues and bodily fluids that will give us more information about that," Sewitch said.
Sewitch said it was a nurse at the hospital who, remembering a case of thallium poisoning in the 1990s in China, suggested doctors include a test for thallium when Wang did not respond to treatment and continued to worsen. He said Wang lapsed into a coma Jan. 22 or 23.
He said Li, who was a research chemist in the Lawrenceville office of Bristol-Myers Squib, had access to thallium at work, but he would not comment on whether or not that's where she may have allegedly obtained it.
Sewitch said the estranged couple, who were living together in the home they purchased in September 2008, were due to have their divorce finalized on Jan. 14, the day Wang took himself to the hospital.
Steven Altman, Li's attorney, said his client denies having anything to do with her hu*****and's death.
Neither Altman nor Sewitch would comment on why police were called to the couple's home several times, beginning in April 2009, for "domestic disturbances."
Sewitch did say no one was injured and no restraining orders were ever filed as a result of the police visits.
Li was remanded to the Middlesex County jail in lieu of $4.15 million bail and is also charged with hindering her own apprehension by "lying to police" when they began investigating Wang's death, Sewitch said.
Doctors, scientists searched for antidote for Monroe man dying from thallium poisoning
Published: Thursday, February 10, 2011, 7:15 AM Updated: Thursday, February 10, 2011, 8:40 AM
http://www.nj.com/news/index.ssf/2011/02/doctors_scientists_led_heroic.html
MONROE — Dressed in green jail garb and with her hands cuffed in front of her, 40-year-old chemist Tianle Li stood before a judge in New Brunswick on Wednesday and listened with quiet composure as she was charged with murdering her hu*****and by dosing him with a rare lethal drug.
Li’s lawyer, Steven Altman, entered a plea of not guilty, and a few minutes later, the hearing was over.
But while the legal part of this story was sorting itself out, startling details were emerging about a frantic, heroic attempt by doctors, scientists, and federal and state agencies to save the dying hu*****and as he lay in a hospital, slipping away from thallium poisoning.
The scramble to save 39-year-old Xiaoye Wang began around 9 p.m. on Jan. 25, when Steven Marcus, the medical and executive director of New Jersey Poison Control, received a call from University Medical Center in Princeton. A doctor was on the other end of the line telling him about Wang and that thallium had been discovered in his system.
Marcus couldn’t believe what he was hearing. This was only the second time in his 43-year medical career that he’d come across a case of thallium poisoning. The physician at the Princeton hospital knew little about the deadly chemical and even less about how to treat it.
"It’s either attempted suicide," Marcus told the doctor, "or homicide."
There was silence on the other end of the phone, Marcus said.
Then he told the physician there was only one way to save Wang’s life — an antidote called Prussian Blue — and only one company in the United States manufactured it.
Thallium is tasteless and odorless and was used in rat poisoning and insecticides until it was banned in the United States in the 1980s because of its toxicity. It is still used in small doses in glass-making, mirror circuits and certain medical tests.
Marcus, who says his nickname is "House," a reference to the television character because he’s often called about perplexing medical cases, said his first thought was to contact everyone he could think of who might be able to help.
One of the first he reached out to was a former colleague at the U.S. Department of Energy’s Oak Ridge National Laboratory in Tennessee. Marcus had taken a course there 10 or 15 years earlier and remembered asking at the time if the lab kept antidotes on hand for thallium.
A year or so prior to that he had been contacted by doctors treating a New Jersey schoolteacher for thallium poisoning. The woman eventually recovered and no one was ever arrested, but the unusual case had stayed with him.
At 5 a.m. on Jan. 26, as scientists at Oak Ridge tried to figure out how to get Prussian Blue to New Jersey in the middle of a snowstorm, Marcus shoveled his driveway in North Jersey, then headed to Princeton, continuing to make calls the entire way — to the state Health Department, to New York City poison control, to anyone who might have Prussian Blue in stock and was closer than Tennessee.
No one did, but Christopher Rinn, the assistant commissioner of New Jersey’s Department of Health and Senior Services, told Marcus the agency was at his disposal.
"He said, ‘Whatever you need. Let’s cut through this bureaucracy,’" Marcus recalled.
By this time, however, Wang was unconscious. He had come to the hospital in Princeton on his own on Jan. 14, the same day he and Li were due in court to finalize their divorce, said Middlesex County Assistant Prosecutor Nicholas Sewitch, who confirmed after Li’s arraignment Wednesday that Wang was administered a "lethal, massive" dose of thallium.
A neighbor living near the couple’s home in Monroe Township, who identified herself only by her last name, Patel, said the two were "not friendly. We didn’t talk ... We knew they were having problems. We saw the cops there all the time."
Sewitch was unable to say how the thallium was administered or whether it was given in several small doses over time, or in one dose. All he would confirm is that the drug was ingested in December or January. He also would not comment on where Li allegedly obtained the thallium, but did say it would have been available to her at Bristol-Myers Squibb in Lawrenceville, where she’s worked since 2001 as a research chemist.
When Wang first arrived at the hospital on Jan. 14, Wang was experiencing "flu-like" symptoms, Sewitch said.
Thallium poisoning typically includes loss of hair, thickened skin, severe gastrointestinal pain and loss of feeling in the extremities. Wang didn’t present many of those symptoms until a few days after his arrival, Marcus said.
At that point a nurse recalled cases of thallium poisoning in China in the 1990s and suggested Wang’s urine be tested, Sewitch said. No lab in New Jersey was capable of performing the test, so Wang’s urine sample was sent out of state.
Twenty-four hours later, the diagnosis of thallium poisoning was confirmed and Marcus was notified.
"If someone at the hospital had not guessed it might be thallium and tested for it, it might have gone undetected," Marcus said.
With time running out, Marcus suggested to a pharmacist at the Princeton hospital that she contact chemical supply companies in the area to try and obtain a less pure dose of Prussian Blue, which is also used to dye clothes as well as microscopic specimens in biological research.
A dose of the non-medical grade was found in a matter of hours and rushed to Princeton the medical center, but Marcus and the other doctors realized they had no idea how much of it to administer.
Still traveling through snow and ice, Marcus suggested diluting the bright blue powder in water and simply doubling the recommended dose.
Nearly two hours after leaving his home, Marcus arrived in Princeton. The non-medical grade Prussian Blue had been administered through a gastric tube, but Wang had showed no response.
In the meantime, Marcus had contacted a federal facility near Albany, N.Y., that had the purer form of the antidote, and an SUV was dispatched to Princeton. When it finally arrived five hours later, Wang was near death.
The antidote would be useless. Marcus, along with a number of doctors and nurses, stood beside Wang’s bed, unable to do anything more.
Sometime around 3 p.m. on Jan. 26, as several detectives stood nearby, Wang’s heart monitor flatlined.
"There was remarkable cooperation between the hospital, poison control, the police, the state health department, the Centers for Disease Control and the nuclear energy department in Tennessee — all to get this antidote to the hospital in snow in a matter of a few hours," Marcus said. "Unfortunately it was too late."
By Amy Ellis Nutt and Sue Epstein/The Star-Ledger
Staff writer Amy Brittain contributed to this report.
Before Monroe man's fatal poisoning, couple had history of domestic disputes
Published: Thursday, February 10, 2011, 9:45 PM Updated: Friday, February 11, 2011, 5:31 AM
MONROE — Xiaoye Wang’s marriage to Tianle Li saw bitter arguments that frequently brought police to the couple’s home in Monroe Township.
"There were a fair number of calls (to police)," Middlesex County Assistant Prosecutor Nicholas Sewitch said today. "More than five."
Things got so bad that Wang, 39, filed for divorce in July, citing irreconcilable differences. He also sought joint custody of the couple’s 2-year-old son, Isaac.
Li, 40, counter-sued a month later, citing the same reason and adding there was "no hope for reconciliation."
The couple’s 10-year marriage appeared to be over.
But on Jan. 14, the day a hearing would be held to finalize the divorce, Wang admitted himself to the University Medical Center in Princeton with "virus-like" symptoms. He died 12 days later from thallium poisoning, which authorities allege was administered by his wife.
Li remained at the Middlesex County jail in North Brunswick today in lieu of $4.15 million bail, charged with murder and hindering her own apprehension. Her attorney, Steven Altman, said his client denies having anything to do with her hu*****and’s death.
Records indicate Wang moved out of the couple’s home on Stanley Drive home in Monroe sometime in June and into a Jersey City apartment.
Preceding the legal steps to end their marriage were calls to police, starting in April 2009 — about seven months after they had moved to Monroe.
Sewitch said none of the calls resulted in charges because there was never any sign of violence or injury to either Li or Wang. While Sewitch would not comment on the origin of the couple’s disputes, neighbors said they often heard them arguing and witnessed frequent visits by police officers.
Wang worked as a computer software engineer in New York City, while Li is a research chemist at the Lawrenceville offices of Bristol-Myers Squibb, the pharmaceutical giant.
After Wang admitted himself into the hospital, his condition progressively deteriorated until he died Jan. 26, the day after doctors finally determined he was suffering from thallium poisoning. After much searching, an antidote was found but by the time it arrived at the hospital, Wang was near death and nothing could be done to save him.
The divorce hearing, which was postponed due to his illness, had been rescheduled for today.
Thallium is a highly toxic heavy metal that is tasteless and odorless. It was once used in rat poison and insecticides, but was banned for that use in the United States and other counties in the 1980s. It is still used in glass and electronics manufacturing and medicinally in stress tests to help diagnose coronary artery disease.
Sewitch has not said how the thallium was administered, nor whether it was given in several small doses over time or in one dose. All he would confirm was that it was ingested in December or January. He also would not comment on where Li allegedly obtained the thallium, though he did say it would have been available to her at Bristol-Myers, where she’s worked since 2001.
關於鉈：
http://wenwen.soso.com/z/q804178.htm
鉈無色、無味 ,一般人不易取得 ,毒性強烈。一般認為 ,鉈對成人最小致死量約為 12ｍｇ/ｋｇ ,
5～ 7. 5ｍｇ/ｋｇ的劑量即可引起兒童死亡。
臨床表現 :
鉈中毒的主要表現為惡心、嘔吐、腹部絞痛、腹瀉等 ,嚴重者有腸道出血 ,繼而出現四肢感覺過敏、針刺感 ,
下肢無力 ,腳跟疼痛 ,甚至癱瘓。中樞神經受損時 ,可出現神誌不清、譫語、抽搐、休克等 ,中毒者多因呼吸
循環功能衰竭而死亡。上述表現與感染性多發性神經炎相似 ,易誤診。脫發是鉈中毒的特殊症狀 ,
常於第二周開始 ,重症可全部脫落 ,一般脫後能再生、皮膚幹燥、脫屑 ,可出現皮疹、痤瘡、皮膚色素沉著、
手掌及足蹠部角化過度 ,指甲和趾甲於第 4周可出現白色橫紋。部分患者有肝、腎、心肌損害的臨床表現。
治療措施 :
1.急性口服中毒患者 ,應立即給予催吐、洗胃、導瀉。洗胃可用 1%的碘化鈉或碘化鉀溶液 ,使之形成不
溶性碘化鉈。隨後可口服活性炭 0. 5ｇ/ｋｇ ,以減少鉈的吸收 ,吸入中毒患者 ,應立即將患者移至空氣
新鮮處 ,吸氧 ,保特呼吸道通暢。皮膚汙染者立即用肥皂水清洗 ,眼部接觸時用大量清水衝洗。
2.普魯士藍是一種無毒色素 ,鉈可置換普魯士藍上的鉀後形成不溶性物質隨糞便排出 ,對治療經口
急慢性鉈中毒有一定療效。用量一般為每日250ｍｇ/ｋｇ ,分 4次 ,溶於 50ｍｌ的 15%甘露醇中口服。
3.對嚴重中毒病例 ,可以使用血液淨化療法 ,有研究表明血液灌流有較好的效果。
4.高鉀能增加腎對鉈的清除 ,可能與鉀競爭性阻內的鉈到細胞外 ,使血鉈含量增加 ,可使臨床病情加重 ,
因此要慎用。
5.維持呼吸、循環功能 ,保護肝、腎、心等髒器 ,給予足夠的Ｂ族維生素。對重度中毒者可使用腎上
腺糖皮質激素製劑。
