More particularly, if you applied through EB1a/NIW, you can certainly walk away from your current position and work in a similar field with EAD in another Univ or Industry and further change to another company.
For Eb1b or EB2-perm or EB3, to keep your 485 valid, you have to fulfill 180 days service for sponsored employer after submitting 485 before using EAD or change company with H1B.