change lab soon,NIW now/later?

I am doing postdoc, and will change to a new lab in
several months.
I am currently in immunology field, but the new lab
is doing cancer research. They seems a little different,
even both are in biology field.

I wonder if I can submit my NIW application before leaving,
or do it later, in the new lab? I have to wait a longer time
to apply in the new lab, to get help from new boss.

any comments will be appreciated.
Thanks

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