Could I have two full-time H1Bs with two companies?
Yes.
2). If yes, will the second H1B affect my I-485 petition approval? any risk for me?
It could not affect your 485, but you need to apply for new H1b visa for the second job.
Yes.
2). If yes, will the second H1B affect my I-485 petition approval? any risk for me?
It could not affect your 485, but you need to apply for new H1b visa for the second job.