RE: 如此EB2-NIW 的RFE 如何回答？

I think you should prepare the case very carefully, get more convincing evidence. The letters from big guys are important, but not that important, since they are just personal letters. If you can find some public comments about your work, like comments on your work in review papers and the introduction of your work in public media, they will weigh 100 times more than the letters from big guys. If no review papers mentioned your work, no public media introduced your work, this is the inherent disadvantage, you have to ask more references. The personnels in USCIS are also common people, if you work there, which is more convincing do you think, a public comments or a personal letter from a big guy? It is very obvious.