If your 140 is EB11 or NIW, you can change to any job in your field. If yours is an employer sponshored 140, you need to find a similar job.CIS compares job code and deion to make a decision. In your case, assuming yours being an employer sponshored 140, then research associate or senior research worker are fine. I are not sure senior technican. However, if the job deion is similar, it will be fine.