US Secretary of State Antony Blinken's first visit to China on Sunday comes nearly five months after a major rupture in relations over a Chinese spy balloon.
His original trip was abruptly cancelled because the balloon, which China says was monitoring weather, drifted across the continental US before being destroyed by American military aircraft.
Mr Blinken's visit includes meetings with China's top foreign policy officials but there is no word yet on whether he will also meet Chinese President Xi Jinping, who appeared with Microsoft founder Bill Gates in Beijing on Friday.
The two global superpowers have a long list of issues that concern them, including high-profile disagreements as well as potential areas of co-operation.
Here are three key areas that could be at the top of the agenda.
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Mending relations
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Easing trade conflicts
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War and peace