Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
Abstract
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
- PMID:
- 2148781
- https://www.ncbi.nlm.nih.gov/pubmed/2148781
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