It wasn't desireable for Melo to do ISO in the 4th quarter, but he didn't have a choice. Honestly, the team didn't have much of a choice. Everyone is gassed due to intense defensive plays. Shumpert couldn't control the ball, JR's shots were off, BD was useless in the 4th, Novak couldn't get himself open.
They were short-handed. What plays would you suggest them run, who would you suggest them give the ball to? Melo was their only weapon, and he tried his best.
It's an away game, and Pacers aren't push-overs. They need Amare and Lin. I am pretty sure Melo would love to score 10-15 points less and get and win, but who should make up that 20 points?