西門慶多日腰酸腿疼，頭沉沒勁。看了燈市後，再戰王六兒， 晚酩酊大醉回家倒在金蓮屋裏。金蓮饑渴如狼，吃一丸胡僧藥， 把剩餘三丸，就燒酒全送到丈夫口中。不料魔藥凶猛，如火山爆發，頓時西門慶白漿噴紅漿湧，一瀉千裏昏死過去。數日請醫求神問卜，無奈酒色無度， 腎水早枯. 西門慶亡年33。
正妻月娘喪偶之時正是生兒之刻，二妻李嬌兒趁機箱子大開偷走大洋，夥計們也分贓柺財。 西門慶臨終前還資產倒背如流：三綢布店， 一藥鋪，船貨，貸款共六萬銀子有餘。 Ximen has been weak for days. Right after the Lantern Festival, he visits and plays with Wang liu-er again, gets back home drunk, he passes out in Jin’s room. Jin is as hungry as a wolf, takes a pill of “Viagra” and feeds three pills to Ximen in his wine. Unexpected, the drug power is like a volcano, causing white and red lava pouring out of Ximen's body. He fainted away. For days, doctors and monks have been helpless. Finally, Ximen dies at age 33.
The moment Ximen dies, his 1st wife gives birth to a son. During this time, his 2nd wife is busy stealing his money and his workers act like vultures raiding his businesses.
Before Ximen dies, he still talked about all of his assets: three silk stores, one drug store, one boat of goods and uncollected debts, all are worth of 60,000 pieces of silver.