CLEVELAND -- Johnny Manziel had scrambled away long before Asdrubal Cabrera came to the plate in the 12th inning. Asics Gel Lyte III Rose Gold . And when Cabrera connected for a three-run homer in the 12th inning, ending a game that took nearly seven hours to play, Indians manager Terry Francona was relieved to be finally leaving the ballpark. "Nice to see anyone come through," Francona said. Cabrera connected for a three-run homer with one out in the 12th, giving Cleveland a 7-4 victory over the Boston Red Sox early Thursday and a three-game sweep of the defending World Series champions. With two runners on and Boston playing five infielders and only two outfielders, Cabrera made the shift moot by driving an 0-1 pitch from Edward Mujica (2-2) into Bostons bullpen as the Indians won their sixth straight overall and ninth in a row at home. Cleveland is an AL-best 21-11 at Progressive Field. Cabrera slid into home plate after his fifth homer and was doused with water by his teammates, who were relieved to finally end a game that didnt finish until 2:02 a.m. The start of the game, originally set for 7:05 p.m., was delayed by rain until 9:33 p.m., cancelling a scheduled ceremonial first pitch by Manziel, the Browns popular rookie quarterback, who flashed his signature "money" gesture when he and his teammates were introduced to the crowd. With practice on Thursday, Manziel ducked out early and was long gone when the game ended with just a few thousand die-hard fans in the seats. The teams each used seven pitchers, who combined to throw 364 pitches. "Regardless of the time, anytime you go 12 innings, losses sting a little bit," Red Sox manager John Farrell said. "We were doing everything we could to extend the ballgame. Guys came out of the bullpen and did a good job. Cabrera just got hold of a breaking ball and put an end to this one." Mujica didnt make any excuses. "That pitch was a big mistake and he hit it out," he said. "I left it over the plate. It was a little crazy, but we had to keep it going however we could." Carlos Carrasco (1-3), the Indians seventh pitcher, worked two innings. The surging Indians have trimmed seven games off first-place Detroits lead in the AL Central in 17 days. Cleveland is within 3 1/2 games and back to .500 for the first time since April 24. David Ortiz homered for the Red Sox, who came in riding a seven-game winning streak but are now headed in the wrong direction. Trailing 4-2 and in danger of leaving town winless, the Red Sox tied it in the seventh inning when they chased Indians starter Corey Kluber on Brock Holts two-run single. Kluber, who was so dominant in May going 4-0 with 60 strikeouts in 43 innings, walked Stephen Drew to start the seventh and Daniel Nava singled. Jackie Bradley Jr. sacrificed and Holt followed with his game-tying base hit to centre. Kluber got a no-decision and remained unbeaten in seven starts since April. He allowed four runs and five hits in 6 1-3 innings. Michael Brantley had three hits off Boston starter Brandon Workman, who pitched while appealing a six-game suspension for throwing at Tampa Bays Evan Longoria last week. Workman gave up three runs in five innings. Ortizs 13th homer gave the Red Sox a 2-1 lead in the sixth. Kluber blanked Boston over the first five innings but opened the sixth by hitting Xander Bogaerts in the right elbow. The right-hander retired Dustin Pedroia on a hard liner to right, but wasnt so fortunate with Ortiz, who ripped a fastball over the fence in right-centre -- a 422-foot shot -- to give the Red Sox their first lead of the series. It didnt last long. The Indians scored three runs in the sixth on an RBI single by Jason Kipnis and another clutch hit by David Murphy, who is batting .383 (18 of 47) with 31 RBIs with runners in scoring position. Brantley picked up his 23rd RBI in his past 32 games in the first with a one-out single to give Cleveland a 1-0 lead. In the fifth, Brantley helped Kluber by making a leaping catch at the left-field wall to rob Bradley of extra bases. NOTES: It was the Indians fifth walk-off win. They are 4-1 in extra inning. ... Red Sox C A.J. Pierzynski was ejected in the sixth by plate umpire Quinn Wolcott. ... Brantley is batting .349 (45 of 129) in 32 games since April 29. ... Indians RHP Danny Salazar was placed on the 7-day DL at Triple-A Columbus with a strained right triceps. Francona doesnt think the injury is serious and expects Salazar, who started Clevelands playoff game last October, to miss "one or two starts." ... Indians RHP Zach McAllisters rehab start with Lake County (A) was rained out and pushed to Thursday. The right-hander, out with a sore lower back, is expected make a second start in the minors. Nike Juvenate Trainers In Black . -- The Erie Otters won their eighth straight game with a four-goal outburst in the third en route to an 8-4 win over the Sarnia Sting in Ontario Hockey League play Saturday. Nike Juvenate Grey Trainers . Toronto (7-9) visits Montreal (8-8) for its first road game in five weeks. The Argos went 3-1 on a recent homestand, including a 26-24 victory over the Hamilton Tiger-Cats on Saturday that gave them the season series with their longtime rivals.LOUISVILLE, Ky. -- Ohio quarterback Tyler Tettleton and running back Beau Blankenship had seen everything in their first three seasons with the Bobcats except a loss in a season-opening game. That streak ended at four Sunday as No. 9 Louisville rolled to a 49-7 win. "We didnt give them much resistance, but the way they played, the way they executed, the quality of athlete that theyve got -- I think its definitely a top-10 team," Bobcats coach Frank Solich said. "Certainly, I think its the best overall team since Ive been at Ohio that weve played." Ohio (0-1) beat Penn State 24-14 to open last season but an upset over Louisville would have been on a much bigger scale. The Cardinals (1-0) are expected to be a part of the BCS national championship picture, and quarterback Teddy Bridgewater entered the season as a potential Heisman Trophy candidate. The Bobcats had hoped to hang with the Cardinals with their offence. That didnt happen. Ohio went three-and-out on its first two possessions, and the third drive ended after six plays with an interception on third and 16. The Bobcats were down 21-0 at that point. "We knew they had a great offence, and we felt like that to keep up with them, wed probably have to score almost every possession," Tettleton said. "Its just one of those days that we werent clicking. Give a lot of credit to them. They have a really good defence." Tettleton finished 11 of 23 for 140 yards. Blankenship, who set a school record with 1,604 rushing yards last season, finished with 22 yards on 12 carries. The Cardinals outgained Ohio 615-273. In contrast, Bridgewater had Louisville up by two touchdowns before he threw an incomplete pass..Asics Gel Kayano 20. He hit his first nine passes and matched a career best with five touchdown throws. Bridgewater kicked off his Heisman Trophy campaign by going 23 of 28 for 355 yards. Damian Copeland and Kai De La Cruz each caught two touchdown passes and DeVante Parker and Robert Clark each had one. Michael Dyer, the former Auburn star, debuted for Louisville and broke off a 46-yard touchdown run in the third quarter. Like last season, Bridgewater involved many targets in the offence and found them wide open much of the day. Parker was at least 10 yards past a defender when he caught a 27-yard pass for the Cardinals third TD in the second quarter. De La Cruz meanwhile had 20 clear yards in front of him after catching Bridgewaters pass for a 40-yard touchdown in finishing with team and career highs of 116 yards on four catches. Only Clark faced Ohio coverage before diving for his 25-yard score late in the third quarter. Backup Will Gardner followed Bridgewater in the fourth but didnt miss a beat, hitting De La Cruz for 30-yard touchdown for a 49-7 lead. Louisville had hiccups such as four false starts and a face mask penalty in the first quarter. A pass interference penalty late in the third quarter helped Ohio break the shutout as Ryan Boykin scored from 10 yards. But those were the only mistakes on a day that the Cardinals cruised. "They were hitting on all cylinders today," Solich said. "Bridgewater was precision-perfect on a lot of throws. At times, we made it a little easier than we should have made it for them as far as leaving receivers wide open. Still, their passing attack obviously was a great passing attack." 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