主演：劉鈞 王挺 趙芮 於月仙 解昕恰
本劇講述了張家口巨商王瑞昌在張庫大道上的經商奮鬥的故事，再現了時局動蕩下這條中國北方唯一的進出口貿易陸路通道的興衰史。
年滿18歲的王瑞昌隨舅舅赴張家口經商，孫家鏢局為其押貨。鏢局逆子馬戎暗中相好、劫鏢之事敗露後，馬戎逃出孫家當上土匪頭目。
王瑞昌立誌經商發達，光耀門相。他到成記皮行學做皮貨生意，從最底層做起，雖吃了不少苦，但卻學到了一身真本事。
為了將皮行的生意做得更大，王瑞昌不畏路途艱險，決定親自跟隨“德盛隆”商號遠走庫倫。此時馬戎卻率令眾土匪襲擊王瑞昌的家，強奸了孫承霞，並將周一龍擄走。王瑞昌從庫倫滿載而歸，孫承霞卻發現自己懷上了馬戎的孽種。她自覺對不住王瑞昌，卻有苦難言，在痛苦猶豫中生下兒子孝鑫。
十三響教唆孫承貴偷光了成記皮行的錢，並將其父孫大成毒死。十三響的養女杏花不願受孫承貴淩辱，向王瑞昌求助，王瑞昌將她帶回家中。
為了東山再起，王瑞昌獨自遠走庫倫，楊伯雷買通馬戎，命他幹掉王瑞昌和李望達。在二人性命攸關之際，孫承霞兄弟及時相救，馬戎再次逃脫……
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