CHEMISTRYANDPHARMACOLOGY
Muraglitazarisanovel,non-thiazolidinedionePPARalpha/gammadualagonist.ItissynthesizedfromoxybenzylglycineandhasshowntohavehighbindingaffinitytothePPARalphaandPPARgammareceptors.Whencomparedwithrosiglitazone,muraglitazarwasfoundtohavecomparablefunctionalactivityatPPARgamma.Whencomparedwithfenofibricacid,aweakPPARalphaagonist,muraglitazarwasfoundtobemorepotentatPPARalpha...[
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Cholesterol:awaxy,fat-likesubstancepresentineverycellinthebodyandinmanyfoods.Somecholesterolinthebloodisnecessary-butahighlevelcanleadtoheartdisease.[
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