華陀再世
一個中國醫學生(CMG)在美國的生活。。。
正文
馬薩諸塞州，波士頓訊—來自兩項前瞻性的隊列研究的數據顯示，ABO血型是發生冠狀動脈性心髒病的危險因素。A、B或AB型血的人較O型血的人患冠狀動脈性心髒病的風險要高5%至23%，經多變量調整其他危險因素或飲食因素後，這種相關性仍存在。
這項由Meian He博士（Harvard School of Public Health, Boston, MA）進行的分析包括了NHS研究中的62073名女性和HPFS研究中的27428名男性。結果發表在2012年9月的《動脈硬化、血栓和血管生物學》雜誌上。
在NHS和HPFS研究中，冠心病的發病率在O、A、B和AB型的婦女分別為125、128、142和161人每100000人每年；O、A、B和AB型的男性分別為373、382、387和524人每100000人每年。在調整年齡後的模型中，與O型血的人相比，A、B、AB型血的人患冠心病的風險分別上升5%， 11%，和23%。在多變量調整後的模型中，這一血型與患病風險的伴隨關係沒有顯著改變。ABO血型與患冠心病之間經年齡調整後的風險比（95%可信區間）研究者同時進行分析，檢驗非O型血的人患冠心病的風險。與O型血的人相比，A、B和AB型血的人患冠心病的風險升高9%，經調整其他危險因素後，此風險有所改變。
類似的，將NHS、HPFS和其他四項前瞻性研究結合起來進行分析，共包括了114648名對象，發現非O型血的人較O型血的人，患冠心病的風險增高6%。據研究者說，總體上，超過6%的冠心病發病可歸咎於A、B或AB血型。
關於風險上升的可能機製， He等人認為，那些非O型血的人，血漿中vWF水平較O型血的人要高將近25%。而vWF水平的升高已被證實是冠心病的危險因素。“vWF在凝血和血栓形成、介導血小板粘附於血管壁的過程中，起重要作用，尤其是在高切應力的條件下。”He和他的團隊解釋說：“同纖維蛋白原一起，vWF還參與血小板聚集，並在粥樣硬化形成過程中扮演重要角色。”另外A型血的人，其總膽固醇和LDL的水平較高。
August 14, 2012 (Boston, Massachusetts) — Data from two prospective cohort studies have identified the ABO blood group as a risk factor for the development of coronary heart disease. Individuals with blood groups A, B, or AB were 5% to 23% more likely to develop coronary heart disease compared with subjects with O blood type, and the associations were not altered by multivariate adjustment of other risk or dietary factors.
The analysis, led by Dr Meian He (Harvard School of Public Health, Boston, MA), included 62 073 women from the Nurses' Health Study (NHS) and 27 428 men from the Health Professionals Follow-up Study (HPFS) and is published in the September 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology.
In the NHS and HPFS, the incident rates of coronary heart disease per 100 000 person-years were 125, 128, 142, and 161 for women with type O, A, B, and AB, respectively, and 373, 382, 387, and 524 for men with type O, A, B, and AB, respectively. Compared with individuals with O blood type, individuals with blood group A, B, or AB had a respective 5%, 11%, and 23% increased risk of developing coronary heart disease in an age-adjusted model. These associations were not significantly altered in the multivariable-adjusted risk model. The researchers also performed an analysis examining the risk of coronary heart disease in patients with non-O blood type. Compared with individuals with O blood type, those with A, B, and AB had a 9% increased risk of developing coronary heart disease, and this risk was unaltered after adjustment for other risk factors.
Similarly, a combined analysis of NHS and HPFS with four other prospective studies, an analysis that included 114 648 subjects, found there was a 6% increased risk of coronary heart disease for those with non-O blood type compared with individuals with O blood.In total, just over 6% of the coronary heart disease cases were attributable to the A, B, or AB blood types, according to the researchers.In terms of possible underlying mechanisms for the increased risk,
He et al note that in non-O individuals, plasma levels of factor VIII-von Willebrand factor (vWF) are approximately 25% higher than in individuals with type O blood type. Elevated levels of factor VIII-vWF have been previously identified as a risk factor for coronary heart disease."The vWF has an important role in hemostasis and thrombosis by mediating platelet adhesion to the vascular wall, especially under high shear stress conditions," explain He and colleagues. "Along with fibrinogen, vWF also participates in platelet aggregation and plays a role in the development of atherosclerosis." In addition, the A blood group has been shown to have higher levels of total and LDL cholesterol.
這項由Meian He博士（Harvard School of Public Health, Boston, MA）進行的分析包括了NHS研究中的62073名女性和HPFS研究中的27428名男性。結果發表在2012年9月的《動脈硬化、血栓和血管生物學》雜誌上。
在NHS和HPFS研究中，冠心病的發病率在O、A、B和AB型的婦女分別為125、128、142和161人每100000人每年；O、A、B和AB型的男性分別為373、382、387和524人每100000人每年。在調整年齡後的模型中，與O型血的人相比，A、B、AB型血的人患冠心病的風險分別上升5%， 11%，和23%。在多變量調整後的模型中，這一血型與患病風險的伴隨關係沒有顯著改變。ABO血型與患冠心病之間經年齡調整後的風險比（95%可信區間）研究者同時進行分析，檢驗非O型血的人患冠心病的風險。與O型血的人相比，A、B和AB型血的人患冠心病的風險升高9%，經調整其他危險因素後，此風險有所改變。
類似的，將NHS、HPFS和其他四項前瞻性研究結合起來進行分析，共包括了114648名對象，發現非O型血的人較O型血的人，患冠心病的風險增高6%。據研究者說，總體上，超過6%的冠心病發病可歸咎於A、B或AB血型。
關於風險上升的可能機製， He等人認為，那些非O型血的人，血漿中vWF水平較O型血的人要高將近25%。而vWF水平的升高已被證實是冠心病的危險因素。“vWF在凝血和血栓形成、介導血小板粘附於血管壁的過程中，起重要作用，尤其是在高切應力的條件下。”He和他的團隊解釋說：“同纖維蛋白原一起，vWF還參與血小板聚集，並在粥樣硬化形成過程中扮演重要角色。”另外A型血的人，其總膽固醇和LDL的水平較高。
August 14, 2012 (Boston, Massachusetts) — Data from two prospective cohort studies have identified the ABO blood group as a risk factor for the development of coronary heart disease. Individuals with blood groups A, B, or AB were 5% to 23% more likely to develop coronary heart disease compared with subjects with O blood type, and the associations were not altered by multivariate adjustment of other risk or dietary factors.
The analysis, led by Dr Meian He (Harvard School of Public Health, Boston, MA), included 62 073 women from the Nurses' Health Study (NHS) and 27 428 men from the Health Professionals Follow-up Study (HPFS) and is published in the September 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology.
In the NHS and HPFS, the incident rates of coronary heart disease per 100 000 person-years were 125, 128, 142, and 161 for women with type O, A, B, and AB, respectively, and 373, 382, 387, and 524 for men with type O, A, B, and AB, respectively. Compared with individuals with O blood type, individuals with blood group A, B, or AB had a respective 5%, 11%, and 23% increased risk of developing coronary heart disease in an age-adjusted model. These associations were not significantly altered in the multivariable-adjusted risk model. The researchers also performed an analysis examining the risk of coronary heart disease in patients with non-O blood type. Compared with individuals with O blood type, those with A, B, and AB had a 9% increased risk of developing coronary heart disease, and this risk was unaltered after adjustment for other risk factors.
Similarly, a combined analysis of NHS and HPFS with four other prospective studies, an analysis that included 114 648 subjects, found there was a 6% increased risk of coronary heart disease for those with non-O blood type compared with individuals with O blood.In total, just over 6% of the coronary heart disease cases were attributable to the A, B, or AB blood types, according to the researchers.In terms of possible underlying mechanisms for the increased risk,
He et al note that in non-O individuals, plasma levels of factor VIII-von Willebrand factor (vWF) are approximately 25% higher than in individuals with type O blood type. Elevated levels of factor VIII-vWF have been previously identified as a risk factor for coronary heart disease."The vWF has an important role in hemostasis and thrombosis by mediating platelet adhesion to the vascular wall, especially under high shear stress conditions," explain He and colleagues. "Along with fibrinogen, vWF also participates in platelet aggregation and plays a role in the development of atherosclerosis." In addition, the A blood group has been shown to have higher levels of total and LDL cholesterol.
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