高風險2型糖尿病人群的藥物預防:臨床試驗成功

來源: 於 2014-03-27 19:01:09 [博客] [舊帖] [給我悄悄話] 本文已被閱讀：次

發表在Diabetes Care的一項研究: 對象為前驅期糖尿病(prediabetes)和/或代謝綜合征(and/or metabolic syndrome (MetS))人群，BMI在27~25 kg/m2之間。受試者接受為期108周的苯丁胺和托吡酯緩釋劑治療，同時進行生活方式調整。結果顯示，這種治療方案可顯著降低體重，並降低發展為2型糖尿病的風險。

CONCLUSIONS  PHEN/TPM ER plus lifestyle modification produced significant weight loss and markedly reduced progression to type 2 diabetes in overweight/obese patients with prediabetes and/or MetS, accompanied by improvements in multiple cardiometabolic disease risk factors.

原文鏈接:

Prevention of Type 2 Diabetes in Subjects With Prediabetes and Metabolic Syndrome Treated With Phentermine and Topiramate Extended Release

注釋:

苯丁胺 = phentermine
托吡酯緩釋劑 = topiramate extended release (PHEN/TPM ER)

Fasting Plasma Glucose (FPG) = 空腹血糖
OGTT = oral glucose tolerance test (口服葡萄糖耐量試驗)
HbA1c = Hemoglobin A1c (糖化血紅蛋白)

 

<span class='tooltip' style='z-index: 1000;'>A1C<span class='definition'>A1C is a test that measures a person's average blood glucose level over the past 2 to 3 months. Hemoglobin (HEE-mo-glo-bin) is the part of a red blood cell that carries oxygen to the cells and sometimes joins with the glucose in the bloodstream. Also called hemoglobin A1C or glycosylated (gly-KOH-sih-lay-ted) hemoglobin, the test shows the amount of glucose that sticks to the red blood cell, which is proportional to the amount of glucose in the blood.<span class='close-tooltip'>X</span></span></span> FPG OGT

 


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