化學酷2023-08-2119:30氟被稱為“asmallatomwithabigego”，是元素周期表中電負性最大的元素，其與碳形成的C-F鍵比碳與其它元素形成的單鍵都要強，因而C-F鍵很難斷裂，更重要的是，在有機分子中引入氟原子或含氟取代基常常會引起其物理、化學性質以及藥理生理活性的改變，這使得含氟化合物在醫藥、農藥及功能材料等領域的應用備受關注。但是，盡管氟在地殼中含量豐富（[閱讀全文]
博文
(2023-08-24 19:05:21)
化學酷2023-08-2119:30氟被稱為“asmallatomwithabigego”，是元素周期表中電負性最大的元素，其與碳形成的C-F鍵比碳與其它元素形成的單鍵都要強，因而C-F鍵很難斷裂，更重要的是，在有機分子中引入氟原子或含氟取代基常常會引起其物理、化學性質以及藥理生理活性的改變，這使得含氟化合物在醫藥、農藥及功能材料等領域的應用備受關注。但是，盡管氟在地殼中含量豐富（[閱讀全文]
(2023-08-16 19:03:26)
MeSO2ClTheformationofmesylateswithmethanesulfonylchloride(MeSO2Cl)isusuallyaccomplishedwithabase(ex.TEAorpyridine),inasolventsuchasDCM,withcoolingoratRT.Apossibleside-pdtisthecorrespondingalkylchloride(seeAlcoholtoChloride-SulfonylChlorides).Example1ToasolutionoftheSM(300mg,2.30mmol)inDCM(6mL)at0CwasaddedTEA(0.64mL,4.6mmol)followedbyMeSO2Cl(0.21mL,2.76mmol).Thereactionmixturewasstirredat0Cfor30min...[閱讀全文]
(2023-08-16 18:14:46)
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(2023-08-14 20:17:51)
DAST(DiethylaminosulfurTrifluoride)OtherNames:N,N-Diethylaminosulfurtrifluoride(Diethylamino)sulfurtrifluorideDiethyl(trifluorosulfido)amineStructure:CASNumber:38078-09-0MolecularWeight:161.19g/molAppearance:ColorlessoilBoilingPoint:30-32Cat3mmHgDensity:1.22g/mLDiethylaminosulfurtrifluoride(DAST)isanucleophilicfluorinatingagentwithwideuseinorganicchemistry.Deoxo-Fluorismorethermallystablealternati...[閱讀全文]
(2023-08-14 17:22:06)
TransesterificationistheprocessofexchangingtheorganicfunctionalgroupR″ofanesterwiththeorganicgroupR'ofanalcohol.Thesereactionsareoftencatalyzedbytheadditionofanacidorbasecatalyst.Thereactioncanalsobeaccomplishedwiththehelpofotherenzymes,particularlylipases(oneexampleisthelipaseE.C.3.1.1.3). Strongacidscatalysethereactionbydonatingaprotontothecarbonylgroup,thusmakingitamorepotentel...[閱讀全文]
(2023-08-12 05:40:10)
Theweigelaflorida'RedPrince'genuswasnamedinhonoroftheGermanscientist,ChristianWeigel.AnancientspeciesfromAsia,fossilevidencesuggeststheseplantshavebeenpresentformillionsofyears,althoughtheydidnotreachEuropeuntilthe19thcentury.Thishardyplantperformsbestwheninfullsun.Thetube-shapedflowersaretheperfectfitforhummingbirdsandthesweetnectarattractsahostofotherpollinators. Theweigelaflorida'...[閱讀全文]
(2023-08-11 19:04:02)
Peegeehydrangea(Hydrangeapaniculata'Grandiflora'),oftenwrittenaspeegee,isaparticularlycold-hardyhydrangeavariety.Thisshrub'sbloomsformlargecone-shapedclusters(panicles)ofwhiteflowersthatdevelopapinkorpurpletintovertime.PeegeehydrangeaishardyinUSDAZones3through8,makingitagreatshrubselectionforlandscapesincoldclimateswhereothertypesofhydrangeaswon'tgrowsuccessfully.Peegeehydrangeasar...[閱讀全文]
(2023-08-07 21:20:43)
PatDussault,UniversityofNebraska-Lincolnpdussault1@unl.eduAugust1,201IntroductionandleadingreferencesThefollowingprovidesabriefintroductiontotheapplicationofozonolysiswithinacademiclabs.Ozonolysisremainsamongthemostfrequentlyusedofmethodsforoxidativecleavageofalkenes.Whilebestknownasameansbywhichtointroducealdehydesandketones,ozonolysiscanalsobeusedtogenerateotherfunctionalgroups.Anoverviewofsomeo...[閱讀全文]
(2023-08-04 19:32:24)
OrganicRoute有機合成路線2023-07-2409:45甲基以及烷基（雜）芳香類化合物苄位上溴反應可以說是有機合成化學中最常見的反應類型之一了，反應屬於自由基類型，反應生成的苄溴類合成砌塊，在醫藥研發中應用非常廣泛，可以與各種親核試劑反應，像疊氮化鈉，胺類，苯酚類，硫醇類等等。這類反應通常使用鹵代溶劑，用的最多的是四氯化碳和二氯甲烷，引發劑一般使用BPO(Benzoylper[閱讀全文]
