認真討論與認知有關的染色體和基因

不好意思，其實俺隻是認真的問了下chatGPT，沒有認真去查每一篇文章， 但是貌似偏差不大啊，如有偏差，也是chatGPT的錯 

下麵是內容(英文在前，中文在後)，大家自己看，俺不做任何評價 LOL

Chromosome 1

• DISC1 (Disrupted in Schizophrenia 1): Associated with cognitive performance and brain development.
  • Reference: Thomson, P.A., et al. "DISC1 Genetics, Cognition and Psychopathology." Molecular Psychiatry, 2013.

Chromosome 2

• NRG1 (Neuregulin 1): Linked to cognitive function and schizophrenia.
  • Reference: Stefansson, H., et al. "Neuregulin 1 and Susceptibility to Schizophrenia." American Journal of Human Genetics, 2002.

Chromosome 3

• CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit): Associated with cognitive performance and sensory processing.
  • Reference: Freedman, R., et al. "Alpha7-Nicotinic Receptor Gene and Sensory Gating: Neurobiological Bases of the Deficit in Schizophrenia." Biological Psychiatry, 2000.

Chromosome 4

• DCDC2 (Doublecortin Domain Containing 2): Linked to reading ability and neuronal development.
  • Reference: Deffenbacher, K.E., et al. "DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain." Proceedings of the National Academy of Sciences, 2004.

Chromosome 6

• DTNBP1 (Dystrobrevin Binding Protein 1): Implicated in cognitive ability and schizophrenia.
  • Reference: Wang, Y., et al. "The DTNBP1 (Dystrobrevin Binding Protein 1) Gene and Its Impact on General Cognitive Ability and Schizophrenia." Biological Psychiatry, 2005.
• KIBRA (WWC1): Associated with memory performance and hippocampal function.
  • Reference: Papassotiropoulos, A., et al. "Human Memory: A Genetic Approach." Advances in Neurology, 2003.

Chromosome 7

• FOXP2 (Forkhead Box P2): Involved in speech and language development.
  • Reference: Lai, C.S., et al. "A Forkhead-Domain Gene Is Mutated in a Severe Speech and Language Disorder." Nature, 2001.
• CHRM2 (Cholinergic Receptor Muscarinic 2): Linked to cognitive ability and IQ scores.
  • Reference: Dick, D.M., et al. "Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence." Behavior Genetics, 2007.

Chromosome 10

• INPP5A: Linked to cognitive ability as measured by the Mini-Mental State Examination and phonemic verbal fluency.
  • Reference: Your provided reference regarding INPP5A.

Chromosome 22

• COMT (Catechol-O-Methyltransferase): Associated with variations in IQ and executive function.
  • Reference: Barnett, J.H., et al. "Cognition in COMT Val158Met Polymorphism: Meta-Analysis of Memory and Executive Function." Biological Psychiatry, 2007.

Chromosome X

• FMR1 (Fragile X Mental Retardation 1): Causes Fragile X syndrome, associated with intellectual disability and autism.
  • Reference: Santoro, M.R., Bray, S.M., & Warren, S.T. "Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective." Annual Review of Pathology: Mechanisms of Disease, 2012.
• OPHN1 (Oligophrenin 1): Linked to intellectual disability and specific cognitive deficits.
  • Reference: Billuart, P., et al. "Oligophrenin-1 Encodes a Rho-GAP Protein Involved in X-Linked Mental Retardation." Nature, 1998.
• MECP2 (Methyl CpG Binding Protein 2): Causes Rett syndrome, a severe neurodevelopmental disorder.
  • Reference: Amir, R.E., et al. "Rett Syndrome Is Caused by Mutations in X-Linked MECP2, Encoding Methyl-CpG-Binding Protein 2." Nature Genetics, 1999.
• ARX (Aristaless Related Homeobox): Linked to intellectual disabilities and epileptic disorders.
  • Reference: Shoubridge, C., Fullston, T., Gecz, J. "ARX Spectrum Disorders: Making Inroads into the Molecular Pathology." Human Mutation, 2010.
• DMD (Dystrophin): Associated with Duchenne and Becker muscular dystrophies and varying degrees of intellectual disability.
  • Reference: Cotton, S., et al. "Cognitive and Behavioral Outcomes of Duchenne Muscular Dystrophy Boys with Mutations Disrupting the Distal Part of the DMD Gene." Journal of Clinical Neuroscience, 2005.

in Chinese?

ChatGPT

好的，這裏是與智力和認知能力相關的染色體及其相關基因的列表，並附有參考文獻：

染色體 1

• DISC1 (Disrupted in Schizophrenia 1)：與認知表現和大腦發育有關。
  • 參考文獻：Thomson, P.A., 等. "DISC1 Genetics, Cognition and Psychopathology." Molecular Psychiatry, 2013.

染色體 2

• NRG1 (Neuregulin 1)：與認知功能和精神分裂症有關。
  • 參考文獻：Stefansson, H., 等. "Neuregulin 1 and Susceptibility to Schizophrenia." American Journal of Human Genetics, 2002.

染色體 3

• CHRNA7 (Cholinergic Receptor Nicotinic Alpha 7 Subunit)：與認知表現和感覺處理有關。
  • 參考文獻：Freedman, R., 等. "Alpha7-Nicotinic Receptor Gene and Sensory Gating: Neurobiological Bases of the Deficit in Schizophrenia." Biological Psychiatry, 2000.

染色體 4

• DCDC2 (Doublecortin Domain Containing 2)：與閱讀能力和神經元發育有關。
  • 參考文獻：Deffenbacher, K.E., 等. "DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain." Proceedings of the National Academy of Sciences, 2004.

染色體 6

• DTNBP1 (Dystrobrevin Binding Protein 1)：與認知能力和精神分裂症有關。
  • 參考文獻：Wang, Y., 等. "The DTNBP1 (Dystrobrevin Binding Protein 1) Gene and Its Impact on General Cognitive Ability and Schizophrenia." Biological Psychiatry, 2005.
• KIBRA (WWC1)：與記憶表現和海馬功能有關。
  • 參考文獻：Papassotiropoulos, A., 等. "Human Memory: A Genetic Approach." Advances in Neurology, 2003.

染色體 7

• FOXP2 (Forkhead Box P2)：涉及言語和語言發育。
  • 參考文獻：Lai, C.S., 等. "A Forkhead-Domain Gene Is Mutated in a Severe Speech and Language Disorder." Nature, 2001.
• CHRM2 (Cholinergic Receptor Muscarinic 2)：與認知能力和智商分數有關。
  • 參考文獻：Dick, D.M., 等. "Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence." Behavior Genetics, 2007.

染色體 10

• INPP5A：與通過簡易智力狀態檢查（Mini-Mental State Examination）和語音流利性測量的認知能力有關。
  • 參考文獻：您提供的關於INPP5A的參考文獻。

染色體 22

• COMT (Catechol-O-Methyltransferase)：與智商和執行功能的變異有關。
  • 參考文獻：Barnett, J.H., 等. "Cognition in COMT Val158Met Polymorphism: Meta-Analysis of Memory and Executive Function." Biological Psychiatry, 2007.

X 染色體

• FMR1 (Fragile X Mental Retardation 1)：引起脆性X綜合征，與智力障礙和自閉症有關。
  • 參考文獻：Santoro, M.R., Bray, S.M., & Warren, S.T. "Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective." Annual Review of Pathology: Mechanisms of Disease, 2012.
• OPHN1 (Oligophrenin 1)：與智力障礙和特定認知缺陷有關。
  • 參考文獻：Billuart, P., 等. "Oligophrenin-1 Encodes a Rho-GAP Protein Involved in X-Linked Mental Retardation." Nature, 1998.
• MECP2 (Methyl CpG Binding Protein 2)：引起雷特綜合征，一種嚴重的神經發育障礙。
  • 參考文獻：Amir, R.E., 等. "Rett Syndrome Is Caused by Mutations in X-Linked MECP2, Encoding Methyl-CpG-Binding Protein 2." Nature Genetics, 1999.
• ARX (Aristaless Related Homeobox)：與智力障礙和癲癇病有關。
  • 參考文獻：Shoubridge, C., Fullston, T., Gecz, J. "ARX Spectrum Disorders: Making Inroads into the Molecular Pathology." Human Mutation, 2010.
• DMD (Dystrophin)：與杜氏和貝克肌營養不良症有關，並導致不同程度的智力障礙。
  • 參考文獻：Cotton, S., 等. "Cognitive and Behavioral Outcomes of Duchenne Muscular Dystrophy Boys with Mutations Disrupting the Distal Part of the DMD Gene." Journal of Clinical Neuroscience, 2005.

 

所有跟帖： 

• 感覺與X有關的都是缺陷型的？正向智商因子反而在其他染色體上？所以，好的X染色體隻是能減少智商缺陷？ -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:26:15

• 高智商往往和某些精神疾病相關聯… -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 12:30:00

• 俺自己的感覺，不一定，隻是方差大些極端的多些 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:31:33

• 我感覺挺複雜。大部分自閉是低智商的，但小部分自閉智商極高 -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 12:36:30

• 的確複雜，沒有簡單的線性關係 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:37:44

• 嗯。線性是數學的概念。我感覺缺陷性的基因，突變的方式有好多種，一些導致低智商一些高。然後多數突變和精神疾病相關。更可能的 -oryzivore- ♂ (33 bytes) () 07/21/2024 postreply 12:46:40

• 肯定是多基因效應，俺早前有個帖子討論過，一定是多染色體上多基因的聯合作用。 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:53:21

• 肯定，我不敢說，大概率吧。你可以開個課題分析一下genomics 大數據啊 -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 13:00:39

• 跟人合作的好多課題都是這個領域的，包括現在單細胞的了 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:07:18

• 等你這方麵的大作出來！ -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 13:11:36

• 多謝！最近真有一篇大文章，他們幹了6年了，各種先進技術都用上了，今年發現最後模型部分難搞，把俺請進來了 -linda2- ♀ (200 bytes) () 07/21/2024 postreply 13:19:09

• 恭喜！ -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 13:22:14

• 多謝！不過還早不知道最後結果 LOL -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:25:51

• 厲害 -兩女寶媽- ♀ (0 bytes) () 07/21/2024 postreply 13:26:45

• LOL，是X 染色體的缺陷是顯性? 生物很爛，隻是瞎想 -zaocha2002- ♀ (0 bytes) () 07/21/2024 postreply 12:48:35

• 不知道是顯性還是隱性，俺個人還沒仔細研究過 LOL -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:54:08

• 這個可以搞個課題開始研究 -zaocha2002- ♀ (0 bytes) () 07/21/2024 postreply 12:59:56

• 感覺更多的是微效多基因 LOL -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:08:51

• 互相作用? -zaocha2002- ♀ (0 bytes) () 07/21/2024 postreply 13:20:03

• 是的，既有累加效應也有交互效應 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:21:23

• 差異不小。但政治正確不能多說：） -西東人8- ♂ (0 bytes) () 07/21/2024 postreply 12:28:24

• 7號和22號染色體與IQ相關！ -linda2- ♀ (0 bytes) () 07/21/2024 postreply 12:29:22

• 讀後感，怪不得紫檀怪人多。人能23對染色體都正常然後頭腦正常，真是個奇跡 lol -Bailey4321- ♀ (0 bytes) () 07/21/2024 postreply 12:31:55

• 沒看懂你的發言。讀了好幾遍。。。 -oryzivore- ♂ (0 bytes) () 07/21/2024 postreply 12:37:29

• 就是影響一個人是否正常的基因其實很多，所以想完全健康是不容易的 -兩女寶媽- ♀ (0 bytes) () 07/21/2024 postreply 12:38:55

• 直接說智力就好了 -violinpiano- ♂ (167 bytes) () 07/21/2024 postreply 12:35:08

• 有意思 -兩女寶媽- ♀ (0 bytes) () 07/21/2024 postreply 12:38:09

• 好複雜，早期智力比較重要，後期還要個人努力才行 -恒媽- ♀ (42 bytes) () 07/21/2024 postreply 12:39:45

• 智商智力也是靠權威畫框的。現在殘疾人那麽多懷疑科學出了問題 -julie116- ♀ (0 bytes) () 07/21/2024 postreply 13:07:29

• 應該不是科學出了問題，是大環境對大腦的要求實質高了。如果再回到農業社會，絕大部分人不用學習，殘疾人會少很多的 -兩女寶媽- ♀ (0 bytes) () 07/21/2024 postreply 13:14:03

• 和大腦發育相關的基因很多，但不是說這和"智力"有關。下麵探春說的文章是研究女性被inactivate的X染色體的表達的 -STEMkid- ♂ (54 bytes) () 07/21/2024 postreply 13:20:01

• 感覺她沒讀懂 LOL -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:23:22

• 文章研究的課題不是哪個基因和啥有關，chatgpt 大概和探春一樣，掃描一下abstract就拿過來舉例 -STEMkid- ♂ (0 bytes) () 07/21/2024 postreply 13:27:00

• 自己去看了一下，22號是對的，8號那個CHRM2其實是在第7號 LOL， 已手動改正 -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:28:41

• 砸出你這個專家! -zaocha2002- ♀ (0 bytes) () 07/21/2024 postreply 13:27:37

• 不敢不敢，俺沒做過智力與基因關係的研究 LOL -linda2- ♀ (0 bytes) () 07/21/2024 postreply 13:34:46