非創傷性起因包括

Nontraumatic causes of rhabdomyolysis include:

• The use of alcohol or illegal drugs such as heroin, cocaine or amphetamines
• Extreme muscle strain, especially in someone who is an untrained athlete; this can happen in elite athletes, too, and it can be more dangerous if there is more muscle mass to break down.
• The use of medications such as antipsychotics or statins, especially when given in high doses
• A very high body temperature(hyperthermia) or heat stroke
• Seizures or delirium tremens
• A metabolic disorder such as diabetic ketoacidosis
• Diseases of the muscles (myopathy) such as congenital muscle enzyme deficiency or Duchenne's muscular dystrophy
• Viral infections such as the flu, HIV, or herpes simplex virus
• Bacterial infections leading to toxins in tissues or the bloodstream (sepsis)

A previous history of rhabdomyolysis also increases the risk of having rhabdomyolysis again.