please read insert No.4. This is a legal document.

4 CONTRAINDICATIONS

AMARYL is contraindicated in patients with a history of a hypersensitivity reaction to: • Glimepiride or any of the product’s ingredients [see Warnings and Precautions (5.2)].

Sulfonamide derivatives: Patients who have developed an allergic reaction to sulfonamide derivatives may develop an allergic reaction to AMARYL. Do not use AMARYL in patients who have a history of an allergic reaction to sulfonamide derivatives.