after denied,

it means u fail.. then u have to change ur status back to H1b immediately, if u have the h1B, it won't affect u.
it means the case for GC is denied, u can make other petitions(.EB2 EB1). some ppl 's H1B is over the limit , then in troble....how many years do u have?

why don't u try EB1 now? if u are an outstanding scholar.in Biology, bichem, chem, phamachem etc, the majors are realted to ppl's health. NIW is possible.

u have published some papers,and u can ask some big shots to write recommendation letters for u....