癌症檢測新技術---液體活檢（Liquid biopsies）可能幫助發現肺癌遺傳缺陷

   英國癌研所前兩日的報道:

http://www.cancerresearchuk.org/about-us/cancer-news/news-report/2015-02-27-liquid-biopsies-could-help-spot-genetic-faults-in-lung-cancer

腫瘤治療前需要采樣活檢，根據病人的腫瘤某基因的突變情況而製定針對性的個性化治療方案。但是腫瘤組織采樣活檢有創傷，或有的病人無法采或采不到。最近有越來越多的關於液體活檢（Liquid biopsies）的研究提示血液檢查也能提供基因突變信息而又不需要組織活檢，發表在JAMA Oncology的這一篇新文章就提到: 用肺癌病人的血液能有效地檢測出一個叫做EGFR基因的突變狀況。

腫瘤細胞的DNA會從血液中分離脫落而成“循環中的遊離DNA”，而它可被用於識別導致不同類型的癌症的EGFR基因的突變狀況。

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Experts believe the findings could aid future research by overcoming the difficulty of accessing some tumour samples.

The researchers analysed blood samples from patients with advanced non-small-cell lung cancer and looked for ‘circulating free DNA’ – bits of DNA shed from tumour cells that can be isolated from the blood.

They found that the tumour DNA present in blood samples could be used to identify different types of tumour-causing genetic faults in a gene called EGFR. 

Blood samples could offer an alternative to tumour biopsies in lung cancer patients, according to European researchers.

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論文鏈接: EGFR Mutations in Non–Small-Cell Lung Cancer

也可以看一看這個視頻解釋:

http://cancergrace.org/lung/2014/12/22/top_lung_cancer_highlight_2014_liquid_biopsies/

 

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